Blindness



Low-vision Rehabilitation Program for Low-vision Patients and Care Givers


Conditions:   Low Vision, One Eye, Unspecified Eye;   Low Vision Blindness;   Low Vision Aids
Interventions:   Other: Low-vision rehabilitation program;   Other: No Intervention
Sponsor:   Lawson Health Research Institute
Not yet recruiting - verified May 2017


Laminar Drainage Implant: Safety of a Novel Surgical Treatment for Refractory Glaucoma.


Conditions:   Glaucoma;   Blindness, Acquired;   End-Stage Glaucoma;   Glaucoma Traumatic
Intervention:   Device: Laminar drainage implant surgery.
Sponsor:   Federal University of Minas Gerais
Completed - verified May 2017


Study to Evaluate QR-110 in Subjects With Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene


Condition:   Leber's Congenital Amaurosis
Intervention:   Drug: QR-110
Sponsor:   ProQR Therapeutics
Not yet recruiting - verified May 2017


A Prospective, Multicenter Clinical Trial


Condition:   Corneal Blindness
Intervention:   Device: KeraKlear Non-Penetrating Keratoprosthesis
Sponsors:   KeraMed, Inc.;   National Eye Institute (NEI);   ClinReg Consulting Services, Inc.
Not yet recruiting - verified April 2017


Collision Warning Device for Blind and Visually Impaired


Conditions:   Hemianopia;   Hemianopsia;   Peripheral Visual Field Defect;   Blindness;   Retinitis Pigmentosa;   Glaucoma
Intervention:   Device: Collision warning device
Sponsor:   Massachusetts Eye and Ear Infirmary
Not yet recruiting - verified April 2017


Visual Information Restoration and Rehabilitation Via Sensory Substitution Technology in Children


Condition:   Blindness
Intervention:   Device: BrainPort V200 Device
Sponsor:   University of Pittsburgh
Recruiting - verified December 2016


Evaluation of a Night Spectacle Correction Concerning an Improvement of Mesopic Vision Quality


Condition:   Myopia-Night Blindness
Intervention:   Device: Spectacle/Glasses
Sponsors:   University of Applied Sciences Jena;   IGA OPTIC EG
Completed - verified November 2016


Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families.


Condition:   Leber Congenital Amaurosis
Intervention:  
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed - verified November 2016


Stem Cells Therapy for Corneal Blindness


Conditions:   Corneal Injuries;   Corneal Burns;   Corneal Scars and Opacities
Intervention:   Biological: Ex-vivo cultivated limbal stem cell pool
Sponsor:   L.V. Prasad Eye Institute
Recruiting - verified December 2016


Development of a Cortical Visual Neuroprosthesis for the Blind


Condition:   Blindness
Intervention:   Procedure: Minicraniotomy
Sponsors:   Universidad Miguel Hernandez de Elche;   Hospital IMED Elche
Recruiting - verified December 2016


Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status


Condition:   Vitamin A Deficiency
Interventions:   Dietary Supplement: Conventional white maize;   Dietary Supplement: Provitamin A carotenoid biofortified maize;   Dietary Supplement: Preformed vitamin A fortified maize
Sponsors:   Johns Hopkins Bloomberg School of Public Health;   University of California, Davis;   Newcastle University;   HarvestPlus
Recruiting - verified June 2016


Visual Activity Evoked by Infrared in Humans After Dark Adaptation


Conditions:   Age Related Macular Degeneration;   Retinitis Pigmentosa;   Congenital Stationary Night Blindness;   Colorblindness
Interventions:   Other: Tungsten halogen light with narrow bandpass filters;   Other: ERG;   Other: VEP
Sponsor:   University of New Mexico
Completed - verified September 2016


Clinical Trial of Gene Therapy for the Treatment of Leber Congenital Amaurosis (LCA)


Condition:   Leber Congenital Amaurosis
Intervention:   Genetic: AAV2/5 OPTIRPE65
Sponsor:   MeiraGTx UK II Ltd
Recruiting - verified April 2017


Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65


Condition:   Leber Congenital Amaurosis
Intervention:  
Sponsor:   MeiraGTx UK II Ltd
Recruiting - verified June 2016


Vitamin A Equivalence of the Provitamin A in Biofortified Bananas


Condition:   Vitamin A Deficiency
Intervention:   Other: Provitamin A-biofortified transgenic bananas
Sponsor:   Iowa State University
Completed - verified August 2016


Compensation for Blindness With the Intelligent Retinal Implant System (IRIS V2) in Patients With Retinal Dystrophy


Conditions:   Retinitis Pigmentosa;   Cone Rod Dystrophy;   Choroideremia
Intervention:   Device: Intelligent Retinal Implant System
Sponsor:   Pixium Vision SA
Active, not recruiting - verified January 2017


The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children


Condition:   Vitamin A Deficiency
Interventions:   Other: Pro-vitamin A biofortified cassava;   Other: White cassava
Sponsors:   Wageningen University;   University of Ibadan;   International Institute for Tropical Agriculture
Active, not recruiting - verified November 2016


Effects of EED on Zn Absorption and Retention in Children From a Standard Dose


Conditions:   Environmental Enteric Dysfunction;   Zinc Deficiency;   Vitamin A Deficiency
Interventions:   Drug: 3 mg zinc sulfate supplement;   Drug: 0.5 mg of 13C10-retinyl-acetate
Sponsors:   University of Colorado, Denver;   International Centre for Diarrhoeal Disease Research, Bangladesh
Recruiting - verified May 2017


Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit


Condition:   Vitamin A Deficiency
Interventions:   Dietary Supplement: Vitamin A (<3-day postpartum);   Dietary Supplement: Vitamin A (6 wk postpartum);   Dietary Supplement: Vitamin A (<3-day and 6 wk postpartum);   Dietary Supplement: Placebo
Sponsors:   International Centre for Diarrhoeal Disease Research, Bangladesh;   Peter Bergman, MD, PhD;   Karolinska University Hospital
Completed - verified September 2016


Evaluating Color Perception Under LED Red/Green and Green Dominant Light


Condition:   Color Blindness, Acquired
Interventions:   Device: White LED Flashlight;   Device: Red/Green Green Dominant LED Flashlight
Sponsor:   University of Colorado, Denver
Recruiting - verified October 2016


Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2


Condition:   Leber Congenital Amaurosis
Intervention:   Biological: AAV2-hRPE65v2
Sponsor:   Spark Therapeutics
Active, not recruiting - verified March 2017


Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours


Condition:   Blindness
Intervention:  
Sponsors:   Rutgers, The State University of New Jersey;   Anesthesia Patient Safety Foundation
Completed - verified April 2009


Safety Study in Subjects With Leber Congenital Amaurosis


Condition:   Leber Congenital Amaurosis
Intervention:   Biological: AAV2-hRPE65v2
Sponsor:   Spark Therapeutics
Active, not recruiting - verified March 2017


Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age


Condition:   Vitamin A Deficiency
Interventions:   Other: White-fleshed sweet potatoes;   Other: Orange-fleshed sweet potatoes (boiled);   Other: Orange-fleshed sweet potatoes (fried);   Other: WFSP and capsule of retinyl palmitate
Sponsors:   University of California, Davis;   International Centre for Diarrhoeal Disease Research, Bangladesh
Completed - verified February 2017


A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers


Conditions:   Infected Corneal Ulcers;   Bacterial Keratitis;   Corneal Ulcer;   Childhood Blindness
Intervention:   Drug: Povidone-Iodine
Sponsors:   Los Angeles Biomedical Research Institute;   Thrasher Research Fund;   Research to Prevent Blindness;   University of California, Los Angeles;   Kolokotrones Family Foundation;   University of the Philippines;   L.V. Prasad Eye Institute;   Joseph Eye Hospital
Completed - verified October 2006

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