Throat/Larynx Cancer



Evaluation of a Web-based Decision Aid Tool for Larynx Cancer (T3/T4) Patients.


Condition:   Larynx Cancer
Interventions:   Other: Interviews;   Other: Treatmentchoice Decisional Tool;   Other: Questionnaires;   Other: Interviews with stakeholders
Sponsors:   Maastricht Radiation Oncology;   MUMC;   The Netherlands Cancer Institute
Recruiting


Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma


Conditions:   Carcinoma, Squamous Cell;   Oral Cancer;   Oropharynx Cancer;   Larynx Cancer;   Lip Cancer;   Esophageal Cancer
Interventions:   Drug: Durvalumab;   Drug: Carboplatin;   Drug: Nab-paclitaxel;   Drug: Cisplatin;   Procedure: Surgical resection;   Radiation: IMRT
Sponsors:   UNC Lineberger Comprehensive Cancer Center;   AstraZeneca;   Celgene
Not yet recruiting


Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer


Conditions:   Malignant Neoplasms of Respiratory and Intrathoracic Organs;   Squamous Cell Carcinoma of the Larynx
Interventions:   Radiation: Stereotactic Hypofractionated Radioablation;   Behavioral: Questionnaires
Sponsors:   M.D. Anderson Cancer Center;   Cancer Prevention Research Institute of Texas
Recruiting


Wound Complications in Head and Neck Surgery


Conditions:   Hypothyroidism; Surgery;   Head and Neck Cancer;   Wound Heal;   Laryngeal Cancer;   Laryngeal Fistula
Intervention:   Drug: Levothyroxine
Sponsor:   University of Michigan
Active, not recruiting


A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients


Conditions:   Laryngeal Cancer;   Hypopharynx Cancer
Intervention:   Device: Modified Trans-Esophageal Prosthesis
Sponsor:   HealthCare Global Enterprise Ltd.
Recruiting


WEE1 Inhibitor With Cisplatin and Radiotherapy: A Trial in Head and Neck Cancer


Conditions:   Hypopharynx Squamous Cell Carcinoma;   Oral Cavity Squamous Cell Carcinoma;   Larynx Cancer
Interventions:   Drug: AZD1775;   Drug: Cisplatin;   Radiation: Radiotherapy
Sponsors:   University of Birmingham;   AstraZeneca;   Cancer Research UK
Recruiting


Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal Function


Condition:   Laryngeal Neoplasms
Intervention:   Radiation: IMRT Radiation
Sponsor:   Fox Chase Cancer Center
Recruiting


Pembrolizumab in Combination With CRT for LA-SCCHN


Conditions:   Head and Neck Cancer;   Squamous Cell Carcinoma;   Oral Cavity Cancer;   Oropharynx Cancer;   Hypopharynx Cancer;   Larynx Cancer;   Laryngeal Cancer
Interventions:   Drug: pembrolizumab (MK-3475);   Drug: Cisplatin;   Radiation: Radiation
Sponsors:   Sanford Health;   Merck Sharp & Dohme Corp.
Recruiting


HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer


Condition:   Squamous Cell Carcinoma of the Larynx
Intervention:   Radiation: radiation
Sponsor:   University of Texas Southwestern Medical Center
Active, not recruiting


NewBreez for Airway Protection in Head and Neck Cancer Patients With Chronic Aspiration


Conditions:   Aspiration;   Laryngeal Cancer
Intervention:   Device: NewBreez
Sponsor:   ProTiP Medical
Terminated


Olaparib and Radiotherapy in Head and Neck Cancer


Conditions:   Laryngeal Cancer Stage II;   Laryngeal Cancer Stage III;   Carcinoma, Squamous Cell;   Head and Neck Neoplasms
Interventions:   Radiation: radiotherapy;   Drug: Olaparib
Sponsors:   The Netherlands Cancer Institute;   AstraZeneca
Recruiting


Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia


Conditions:   Oral Complications of Radiation Therapy;   Stage I Laryngeal Cancer;   Stage II Laryngeal Cancer
Interventions:   Procedure: laser therapy;   Other: questionnaire administration
Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
Completed


The Efficacy of Vocal Function Exercises for Laryngeal Cancers


Condition:   Vocal Folds
Interventions:   Procedure: Vocal Function Exercises;   Procedure: Vocal Hygiene
Sponsor:   Vrushali Angadi
Recruiting


Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer


Conditions:   Human Papilloma Virus Infection;   Stage III Squamous Cell Carcinoma of the Hypopharynx;   Stage III Squamous Cell Carcinoma of the Larynx;   Stage III Squamous Cell Carcinoma of the Oropharynx;   Stage III Verrucous Carcinoma of the Larynx;   Stage IV Squamous Cell Carcinoma of the Hypopharynx;   Stage IV Verrucous Carcinoma of the Larynx;   Stage IVA Squamous Cell Carcinoma of the Larynx;   Stage IVA Squamous Cell Carcinoma of the Oropharynx;   Stage IVA Verrucous Carcinoma of the Larynx;   Stage IVB Squamous Cell Carcinoma of the Larynx;   Stage IVB Squamous Cell Carcinoma of the Oropharynx;   Stage IVB Verrucous Carcinoma of the Larynx;   Stage IVC Squamous Cell Carcinoma of the Larynx;   Stage IVC Squamous Cell Carcinoma of the Oropharynx;   Stage IVC Verrucous Carcinoma of the Larynx
Interventions:   Drug: paclitaxel;   Drug: carboplatin;   Radiation: intensity-modulated radiation therapy;   Procedure: quality-of-life assessment
Sponsors:   Jonsson Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting


CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer


Condition:   Early-stage Glottic Larynx Cancer
Intervention:   Radiation: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy
Sponsor:   University of Texas Southwestern Medical Center
Recruiting


Breath Testing in Early and Late Larynx Cancer


Condition:   Larynx Cancer
Interventions:   Other: Breath test- sampling using ENose;   Other: Laryngoscopy and bronchoscopy
Sponsor:   Royal Brisbane and Women's Hospital
Completed


Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer


Condition:   Laryngeal Cancer
Interventions:   Drug: AT-101;   Drug: Docetaxel;   Drug: Cisplatin;   Drug: Carboplatin
Sponsor:   University of Michigan Cancer Center
Recruiting


Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer


Conditions:   Larynx Cancer;   Lip Cancer;   Oral Cavity Cancer;   Pharyngeal Cancer;   Oropharyngeal Cancer
Intervention:  
Sponsor:   Mahesh Kudrimoti
Active, not recruiting


MRI Laryngeal Imaging With a Surface Coil


Conditions:   Laryngeal Neoplasms;   Head and Neck Cancers;   Larynx Cancer
Intervention:   Procedure: MRI scan
Sponsor:   Stanford University
Terminated


Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer


Conditions:   Cancer of the Pharynx;   Cancer of the Larynx;   Cancer of the Neck;   Paranasal Sinus Neoplasms;   Cancer of the Head
Intervention:   Drug: erlotinib + celecoxib
Sponsor:   Johnny Kao
Completed


Photodynamic Therapy Using HPPH in Treating Patients With Dysplasia, Cancer in Situ, or Invasive Cancer of the Larynx


Condition:   Head and Neck Cancer
Interventions:   Drug: HPPH;   Procedure: laser therapy
Sponsor:   Roswell Park Cancer Institute
Active, not recruiting


Long-term Clinical Feasibility of the New Indwelling Provox Vega 20 Voice Prosthesis


Condition:   Total Laryngectomy
Intervention:   Device: Provox Vega voice prosthesis (20 Fr)
Sponsors:   Atos Medical AB;   The Netherlands Cancer Institute
Terminated


Phase II Trial Evaluating Elimination of Radiation Therapy


Condition:   Cancer of the Larynx
Intervention:   Radiation: Intensity modulated radiation therapy
Sponsor:   Washington University School of Medicine
Active, not recruiting


Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population


Conditions:   Pharynx Cancer;   Larynx Cancer;   Oral Cavity Cancer;   Oesophageal Cancer
Intervention:   Procedure: Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
Sponsor:   Gustave Roussy, Cancer Campus, Grand Paris
Completed


Patient Evaluation for Head and Neck Surgery Branch Studies


Conditions:   Head and Neck Neoplasms;   Pharyngeal Cancer;   Oral Cancer;   Carcinoma, Squamous Cell;   Laryngeal Cancer
Intervention:  
Sponsor:   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting

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