Throat/Larynx Cancer

Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer

Conditions:   Malignant Neoplasms of Respiratory and Intrathoracic Organs;   Squamous Cell Carcinoma of the Larynx
Interventions:   Radiation: Stereotactic Hypofractionated Radioablation;   Behavioral: Questionnaires
Sponsors:   M.D. Anderson Cancer Center;   Cancer Prevention Research Institute of Texas
Not yet recruiting - verified April 2017

Wound Complications in Head and Neck Surgery

Conditions:   Hypothyroidism; Surgery;   Head and Neck Cancer;   Wound Heal;   Laryngeal Cancer;   Laryngeal Fistula
Intervention:   Drug: Levothyroxine
Sponsor:   University of Michigan
Not yet recruiting - verified April 2017

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Conditions:   HNSCC;   Lip SCC;   Oral Cavity Cancer;   Oropharynx Cancer;   Larynx Cancer;   Hypopharynx Cancer;   Nasopharynx Cancer;   Sinonasal Carcinoma;   Cutaneous Squamous Cell Carcinoma;   Head and Neck Neoplasms;   Head and Neck Cancer;   Head and Neck Squamous Cell Carcinoma
Intervention:   Drug: Pembrolizumab, Cetuximab
Sponsors:   Assuntina G. Sacco;   Merck Sharp & Dohme Corp.
Recruiting - verified March 2017

A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients

Conditions:   Laryngeal Cancer;   Hypopharynx Cancer
Intervention:   Device: Modified Trans-Esophageal Prosthesis
Sponsor:   HealthCare Global Enterprise Ltd.
Recruiting - verified January 2017

WEE1 Inhibitor With Cisplatin and Radiotherapy: A Trial in Head and Neck Cancer

Conditions:   Hypopharynx Squamous Cell Carcinoma;   Oral Cavity Squamous Cell Carcinoma;   Larynx Cancer
Interventions:   Drug: AZD1775;   Drug: Cisplatin;   Radiation: Radiotherapy
Sponsors:   University of Birmingham;   AstraZeneca;   Cancer Research UK
Not yet recruiting - verified May 2017

Combination of Cryosurgey and NK Immunotherapy for Recurrent Laryngeal Cancer

Condition:   Recurrent Laryngeal Cancer
Interventions:   Device: Cryosurgery;   Biological: NK immunotherapy
Sponsors:   Fuda Cancer Hospital, Guangzhou;   Shenzhen Hank Bioengineering Institute
Recruiting - verified July 2016

Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal Function

Condition:   Laryngeal Neoplasms
Intervention:   Radiation: IMRT Radiation
Sponsor:   Fox Chase Cancer Center
Recruiting - verified January 2017

Pembrolizumab in Combination With CRT for LA-SCCHN

Conditions:   Head and Neck Cancer;   Squamous Cell Carcinoma;   Oral Cavity Cancer;   Oropharynx Cancer;   Hypopharynx Cancer;   Larynx Cancer;   Laryngeal Cancer
Interventions:   Drug: pembrolizumab (MK-3475);   Drug: Cisplatin;   Radiation: Radiation
Sponsors:   Sanford Health;   Merck Sharp & Dohme Corp.
Recruiting - verified May 2017

HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer

Condition:   Squamous Cell Carcinoma of the Larynx
Intervention:   Radiation: radiation
Sponsor:   University of Texas Southwestern Medical Center
Active, not recruiting - verified December 2016

Olaparib and Radiotherapy in Head and Neck Cancer

Conditions:   Laryngeal Cancer Stage II;   Laryngeal Cancer Stage III;   Carcinoma, Squamous Cell;   Head and Neck Neoplasms
Interventions:   Radiation: radiotherapy;   Drug: Olaparib
Sponsors:   The Netherlands Cancer Institute;   AstraZeneca
Recruiting - verified September 2016

Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions

Conditions:   Chronic Inflammation of Hypopharynx;   Hoarseness;   Macroscopic Laryngeal Lesions;   Histological Confirmation of Dysplasia;   Carcinoma in Situ;   Invasive Carcinoma of Larynx;   Invasive Carcinoma of Hypo Pharynx;   Recurrent Respiratory Papillomatosis
Intervention:   Device: NBI endoscopy
Sponsor:   University Hospital Ostrava
Completed - verified September 2016

Pulsed Dye Laser in Treating Patients With Post Radiation Dysphonia

Conditions:   Oral Complications of Radiation Therapy;   Stage I Laryngeal Cancer;   Stage II Laryngeal Cancer
Interventions:   Procedure: laser therapy;   Other: questionnaire administration
Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
Completed - verified February 2017

The Efficacy of Vocal Function Exercises for Laryngeal Cancers

Condition:   Vocal Folds
Interventions:   Procedure: Vocal Function Exercises;   Procedure: Vocal Hygiene
Sponsor:   Vrushali Angadi
Recruiting - verified May 2017

Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer

Conditions:   Human Papilloma Virus Infection;   Stage III Squamous Cell Carcinoma of the Hypopharynx;   Stage III Squamous Cell Carcinoma of the Larynx;   Stage III Squamous Cell Carcinoma of the Oropharynx;   Stage III Verrucous Carcinoma of the Larynx;   Stage IV Squamous Cell Carcinoma of the Hypopharynx;   Stage IV Verrucous Carcinoma of the Larynx;   Stage IVA Squamous Cell Carcinoma of the Larynx;   Stage IVA Squamous Cell Carcinoma of the Oropharynx;   Stage IVA Verrucous Carcinoma of the Larynx;   Stage IVB Squamous Cell Carcinoma of the Larynx;   Stage IVB Squamous Cell Carcinoma of the Oropharynx;   Stage IVB Verrucous Carcinoma of the Larynx;   Stage IVC Squamous Cell Carcinoma of the Larynx;   Stage IVC Squamous Cell Carcinoma of the Oropharynx;   Stage IVC Verrucous Carcinoma of the Larynx
Interventions:   Drug: paclitaxel;   Drug: carboplatin;   Radiation: intensity-modulated radiation therapy;   Procedure: quality-of-life assessment
Sponsors:   Jonsson Comprehensive Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified September 2016

CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy Study for Early-stage Glottic Larynx Cancer

Condition:   Early-stage Glottic Larynx Cancer
Intervention:   Radiation: CyberKnife Accelerated Hemilarynx Stereotactic Radiotherapy
Sponsor:   University of Texas Southwestern Medical Center
Recruiting - verified February 2017

Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer

Condition:   Laryngeal Cancer
Interventions:   Drug: AT-101;   Drug: Docetaxel;   Drug: Cisplatin;   Drug: Carboplatin
Sponsor:   University of Michigan Cancer Center
Recruiting - verified September 2016

Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer

Conditions:   Carcinoma, Squamous;   Head and Neck Cancer;   Oral Cancer;   Laryngeal Cancer;   Pharyngeal Cancer
Interventions:   Drug: Bortezomib (Velcade, PS-341);   Drug: Cetuximab;   Drug: Cisplatin;   Procedure: Radiation Therapy
Sponsor:   National Cancer Institute (NCI)
Completed - verified February 8, 2013

Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer

Conditions:   Larynx Cancer;   Lip Cancer;   Oral Cavity Cancer;   Pharyngeal Cancer;   Oropharyngeal Cancer
Sponsor:   Mahesh Kudrimoti
Active, not recruiting - verified April 2017

Effects of Swallowing Exercises on Patients Undergoing Radiation Treatment for Head and Neck Cancer

Conditions:   Head and Neck Cancer;   Stage I Hypopharyngeal Cancer;   Stage I Laryngeal Cancer;   Stage I Oropharyngeal Cancer;   Stage II Hypopharyngeal Cancer;   Stage II Laryngeal Cancer;   Stage II Oropharyngeal Cancer;   Stage III Hypopharyngeal Cancer;   Stage III Laryngeal Cancer;   Stage III Oropharyngeal Cancer;   Stage IV Hypopharyngeal Cancer;   Stage IV Laryngeal Cancer;   Stage IV Oropharyngeal Cancer
Interventions:   Behavioral: exercise intervention;   Other: questionnaire administration;   Procedure: quality-of-life assessment
Sponsor:   Wake Forest University Health Sciences
Terminated - verified February 2017

Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer

Conditions:   Cancer of the Pharynx;   Cancer of the Larynx;   Cancer of the Neck;   Paranasal Sinus Neoplasms;   Cancer of the Head
Intervention:   Drug: erlotinib + celecoxib
Sponsor:   Johnny Kao
Completed - verified February 2017

Short-term Clinical Feasibility of the New Provox Vega 22.5 Voice Prosthesis

Condition:   Total Laryngectomy
Intervention:   Device: Provox voice prosthesis
Sponsors:   Atos Medical AB;   The Netherlands Cancer Institute
Completed - verified August 2016

Photodynamic Therapy Using HPPH in Treating Patients With Dysplasia, Cancer in Situ, or Invasive Cancer of the Larynx

Condition:   Head and Neck Cancer
Interventions:   Drug: HPPH;   Procedure: laser therapy
Sponsor:   Roswell Park Cancer Institute
Active, not recruiting - verified March 2017

Long-term Clinical Feasibility of the New Indwelling Provox Vega 20 Voice Prosthesis

Condition:   Total Laryngectomy
Intervention:   Device: Provox Vega voice prosthesis (20 Fr)
Sponsors:   Atos Medical AB;   The Netherlands Cancer Institute
Terminated - verified January 2017

Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population

Conditions:   Pharynx Cancer;   Larynx Cancer;   Oral Cavity Cancer;   Oesophageal Cancer
Intervention:   Procedure: Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
Sponsor:   Gustave Roussy, Cancer Campus, Grand Paris
Completed - verified May 2017

Patient Evaluation for Head and Neck Surgery Branch Studies

Conditions:   Head and Neck Neoplasms;   Pharyngeal Cancer;   Oral Cancer;   Carcinoma, Squamous Cell;   Laryngeal Cancer
Sponsor:   National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified January 6, 2017

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