Ear Diseases (General)

Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts

Condition:   Middle Ear Disease
Interventions:   Device: 3D CAD/CAM autograft prosthesis;   Device: Control device
Sponsor:   Nitinetics LLC

Taste Changes in Acute Otitis Media

Condition:   Acute Otitis Media
Intervention:   Diagnostic Test: Electrogustometery
Sponsors:   Tel-Aviv Sourasky Medical Center;   Tel Aviv University
Not yet recruiting

Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion

Conditions:   Otitis Media With Effusion;   Probiotics;   Adenoid Vegetations
Intervention:   Dietary Supplement: Probactiol Mini
Sponsor:   University Hospital, Antwerp

Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa

Condition:   Acute Otitis Externa
Interventions:   Drug: DF289 plus DF277;   Drug: DF289;   Drug: DF277
Sponsor:   Salvat

Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation.

Conditions:   Inner Ear Disease;   Equilibrium; Disorder, Labyrinth;   Spatial Navigation
Intervention:   Other: Vestibular reeducation
Sponsors:   Universidad de Zaragoza;   Aragon Institute of Health Sciences
Active, not recruiting

Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children

Conditions:   Pain;   Acute Otitis Media
Interventions:   Drug: Benzocaine Otic Solution;   Drug: Placebo
Sponsor:   Lachlan Pharma Holdings

The URT and Middle Ear Microbiota in Health and During Chronic OME

Conditions:   Otitis Media With Effusion;   Healthy
Intervention:   Other: Collection of body fluids/swabs
Sponsor:   University Hospital, Antwerp

E-learning on the Trainees' Ability to Diagnose and Treat Acute Otitis Media Among Children

Condition:   Ear Infection
Interventions:   Other: e-learning teaching module;   Other: Standard teaching method
Sponsor:   St. Justine's Hospital

The Effect of General Anesthesia on the Middle Ear Pressure

Condition:   Ear Deformities, Acquired
Interventions:   Drug: desflurane,;   Drug: Sevoflurane
Sponsor:   Trakya University

Clinical Study of Solo Tympanostomy Tube Device (TTD)

Conditions:   Otitis Media;   Middle Ear Effusion
Intervention:   Device: Solo TTD
Sponsors:   Nottingham University Hospitals NHS Trust;   AventaMed DAC;   Derby Hospitals NHS Foundation Trust;   Sheffield Children's NHS Foundation Trust

Xylitol for Otitis Media

Condition:   Otitis Media With Effusion
Interventions:   Drug: Intranasal xylitol spray;   Other: Intranasal saline spray
Sponsor:   Duke University

Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children

Condition:   Acute Otitis Media
Interventions:   Drug: Amoxicillin;   Drug: Amoxicillin-Potassium Clavulanate;   Drug: Macrolide
Sponsors:   University of Oulu;   Oulu University Hospital

Quantification of Prosthesis Penetration With Conebeam in Otosclerosis

Condition:   Otosclerosis
Sponsor:   Fondation Ophtalmologique Adolphe de Rothschild

Shared Decision Making in Parents of Children With Acute Otitis Media

Condition:   Acute Otitis Media
Interventions:   Other: Acute Otitis Media Choice Decision Aid;   Other: Usual Care
Sponsor:   Mayo Clinic

A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea

Conditions:   Otitis Media;   Otorrhea
Interventions:   Drug: piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%;   Drug: piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%;   Drug: piperacillin 2% + tazobactam 0.25%;   Drug: piperacillin 4% + tazobactam 0.5%;   Drug: piperacillin 8% + tazobactam 1.0%
Sponsor:   Yuhan Corporation
Active, not recruiting

Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss

Conditions:   Hearing Loss;   Ear Diseases;   Hearing Disorders;   Otorhinolaryngologic Diseases;   Asymmetrical Hearing Loss;   Single-Sided Deafness
Intervention:   Device: HiResolution Bionic Cochlear Implant
Sponsor:   Advanced Bionics

Phase 3 Study of OTO-201 in Acute Otitis Externa

Conditions:   Acute Otitis Externa;   Swimmer's Ear
Interventions:   Drug: 12 mg ciprofloxacin;   Drug: Sham Control
Sponsor:   Otonomy, Inc.

Video Discharge Instructions for Acute Otitis Media

Condition:   Otitis Media
Interventions:   Other: Video discharge instructions;   Other: Standard of Care
Sponsor:   Lawson Health Research Institute

Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish Children

Conditions:   Acute Otitis Media;   Otitis Media
Intervention:   Other: Data collection
Sponsor:   GlaxoSmithKline

Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults With Partial Deafness

Conditions:   Hearing Loss;   Partial Deafness;   Hearing Disorders;   Ear Diseases;   Otorhinolaryngologic Diseases
Interventions:   Device: HiRes 90K™ Advantage implant with HiFocus™ Mid-Scala electrode;   Device: EAS sound processor
Sponsor:   Advanced Bionics

TransMEM Gas Exchange -- Project 1, Aim 2

Conditions:   Middle Ear Disease;   Nasal Allergy
Interventions:   Biological: ragweed;   Biological: histamine;   Drug: pseudoephedrine;   Drug: Oxymetazoline
Sponsors:   Cuneyt M. Alper;   National Institute on Deafness and Other Communication Disorders (NIDCD)

Long-term Stability and Survival Rates of a Novel Oticon Medical Bone Conduction Device Implant

Conditions:   Deafness;   Hearing Loss;   Hearing Loss, Conductive;   Hearing Disorders;   Ear Diseases;   Otorhinolaryngologic Diseases
Intervention:   Device: Bone anchored hearing implant
Sponsor:   Oticon Medical

Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss

Conditions:   Hearing Loss;   Deafness;   Hearing Loss, Sensorineural;   Hearing Disorders;   Ear Diseases
Interventions:   Drug: Ancrod;   Drug: Saline solution
Sponsors:   Nordmark Arzneimittel GmbH & Co. KG;   ClinSupport GmbH;   MWI Medizinisches Wirtschaftsinstitut GmbH;   ProjectPharm s.r.o.;   LCR Leading Clinical Research s.r.o.;   X-act Cologne Clinical Research GmbH

A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease

Conditions:   Sensorineural Hearing Loss;   Autoimmune Inner Ear Disease
Intervention:   Drug: Anakinra
Sponsors:   Andrea Vambutas;   National Institute on Deafness and Other Communication Disorders (NIDCD)

Genetics of Middle Ear Disease

Condition:   Otitis Media
Sponsors:   University of Pittsburgh;   National Institute on Deafness and Other Communication Disorders (NIDCD)

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