Thyroid Disorders

About Thyroid Disorders Clinical Trials (Click to Open)

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Clinical Trials for Thyroid DisordersGeneral Purpose:

Thyroid disorders most commonly include hypothyroidism, hyperthyroidism, and thyroid hormone resistance. Clinical trials for thyroid disorder intend to improve the scientific understanding of these disorders in order to improve prevention methods, diagnostic measures, and the management of your thyroid disorder.

These trials will evaluate the safety and efficacy of pharmaceuticals for those suffering from thyroid disorder. If you volunteer to enroll in a clinical trial, you will have access to new drugs that are being evaluated before becoming available to the public.

In order to better understand this host of disorders, observational clinical trials will attempt to better understand such aspects as the natural history, clinical presentation, and genetic component of thyroid disorders.

Studies may also examine the affect of thyroid hormone medications on fat and cholesterol metabolism, regulations of blood sugar, and thyrotropin secretion in patients who have had their thyroid glands removed. Studies of this nature will aid in the improvement of pharmacotherapies for regulating blood sugar and cholesterol levels in patients with thyroid disorders.

Some studies may even delve into the affect that bariatric surgery induced weight loss has on thyroid function, with particular focus on post-operative changes in thyroid disorders. Clinical trials may also specifically study a pregnant patient population, because there has been an association between thyroid disease and adverse outcomes, both during pregnancy and in childhood development.

These trials may attempt to evaluate the improvement of thyroid disease treatment during pregnancy to decrease the possibility of adverse effects. Whether you have hypothyroidism or are pregnant and suffering from a thyroid disease, there are innumerable opportunities for gaining both personal benefit and advancing scientific knowledge of thyroid disorders.

What will Clinical Trials for Thyroid Disorders be like?

Prior to enrolling in a clinical trial, potential participants must first undergo enrollment Clinical Trials for Thyroid Disordersscreenings to determine eligibility. These criteria will depend upon the specific disorder being studied, as well as the cohort the study chooses to focus on. These criteria are put in place to promote the validity of the research results.

They are also present to avoid undue risk, which may, for example, result if a participant is taking a medication that might have a detrimental interaction with a trial treatment. Studies intending to evaluate hormone treatment in those without thyroid glands will require participants to have previously undergone some extent of thyroid gland removal.

Candidates will go through extensive screenings, including medical history, physical exam, blood tests, electrocardiogram, neck ultrasound, etc. If the trial is focusing on a specific demographic, then the criteria will exclude everyone but those belonging to that particular group – such as interventional trials for pregnant women or correlational trials post weight loss procedure.

Typical Thyroid Disorder Clinical Trial Protocol:

Observational trials will conduct extensive evaluations of patients with thyroid function disorders. These may include medical histories, physical exams, endocrine tests, TRH tests, thyroid nuclear medicine scans, X-ray, magnetic resonance imaging (MRI), and other standard diagnostic procedures.

In post-operative trials, thyroid morphological changes will be evaluated, as well as BMI, thyroid hormone levels, and thyroxin substitution. Interventional studies will randomly assign participants into different treatment groups, as well as a control group, and will conduct evaluation screenings throughout the duration of the trial at specific time points to determine the efficacy of such treatments.

In trials attempting to determine the effect of treatments on adverse outcomes that occur during pregnancy and the neonatal period, relevant outcome measures will be taken. Offspring may undergo Intelligence Quotient and Wechsler Intelligence Scale for Children to assess the efficacy of treatments in comparison to control groups. 

Suggested Search Terms:

Hypothyroidism, Hyperthyroidism, Pharmaceutical Treatments for Patient’s with Thyroid Gland Removal, Thyroid Disorders in Pregnant Women, Thyroid Dysfunction Changes following Weight loss Surgery

Current Search Term:

“Thyroid”

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Expression of Protein Convertases in Thyroid Nodules


Condition:   Thyroid Nodule
Intervention:   Diagnostic Test: Immunohistochemistry
Sponsor:   Robert Day
Enrolling by invitation - verified May 2017


The Feasibility and Safety of the TOETVA for Benign Thyroid Nodules


Condition:   Thyroid Diseases
Intervention:   Procedure: Transoral endoscopic thyroidectomy vestibular approach
Sponsor:   The University of Hong Kong
Not yet recruiting - verified May 2017


Ultrasound-guided Percutaneous Microwave Ablation for Benign Thyroid Nodules


Condition:   Thyroid Nodule
Intervention:   Device: Microwave Ablation
Sponsors:   Wenjun Wu;   First Affiliated Hospital of Wenzhou Medical Univeristy
Not yet recruiting - verified March 2017


Sestamibi Scans In Thyroglobulin Positive Scan Negative Differentiated Thyroid Cancer Patients


Condition:   Thyroid Cancer
Intervention:   Radiation: 99mTc sestamibi
Sponsor:   Washington Hospital Center
Recruiting - verified May 2017


Comparison of I-124 and I-131 Radiopharmacokinetics in DTC Patients With Thyroid Hormone Withdrawal


Condition:   Thyroid Cancer
Intervention:   Radiation: Radioactive Iodine 124
Sponsor:   Washington Hospital Center
Recruiting - verified March 2017


Molecular Testing to Direct Extent of Initial Thyroid Surgery


Condition:   Thyroid Cancer
Interventions:   Procedure: Thyroid lobectomy;   Procedure: Total thyroidectomy with CCND
Sponsor:   University of Pittsburgh
Recruiting - verified November 2016


Determinants of Thyroid Surgery Outcomes


Condition:   Thyroid Disease
Intervention:   Procedure: Thyroid surgery
Sponsor:   Hospices Civils de Lyon
Completed - verified June 2016


Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology: Pilot Study


Condition:   Thyroid Gland
Intervention:   Device: Radiation : PET-CT with F18-choline examination
Sponsors:   Centre Francois Baclesse;   Canceropôle Nord Ouest
Recruiting - verified May 2016


Randomized Trial Comparing Performance of Molecular Markers for Indeterminate Thyroid Nodules


Condition:   Thyroid
Interventions:   Other: Afirma GEC;   Other: ThyroSeq v.2
Sponsor:   Jonsson Comprehensive Cancer Center
Not yet recruiting - verified August 2016


A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer


Condition:   Thyroid Cancer
Intervention:   Drug: Regorafenib
Sponsors:   Dana-Farber Cancer Institute;   Bayer
Recruiting - verified May 2017


Minimize Radioactive Iodine Ablation Of Remnant Thyroid in Differentiated Thyroid Cancer


Condition:   Thyroid Neoplasms
Interventions:   Drug: I131;   Drug: I123
Sponsor:   National Cancer Center, Korea
Active, not recruiting - verified January 2017


Study on HRQOL and Cost-effectiveness Analysis in Management of Patients With <2cm Thyroid Nodules


Condition:   Thyroid Nodules
Intervention:   Other: Fine Needle Aspiration Cytology
Sponsor:   The University of Hong Kong
Active, not recruiting - verified April 2017


Role of NGS-based ThyroSeq Panel in Cancer Diagnosis in Thyroid Nodules


Condition:   Thyroid Nodule
Intervention:  
Sponsors:   University of Pittsburgh;   Duke University;   Johns Hopkins University;   Ohio State University;   University of Cincinnati;   University of Colorado, Denver;   University of Pennsylvania;   University of Wisconsin, Madison;   Washington Hospital Center
Active, not recruiting - verified January 2017


An Observational Study in Differentiated Thyroid Cancer Which is Radioactive Iodine (RAI) Refractory to Assess the Use of Multikinase Inhibitors


Condition:   Thyroid Neoplasms
Interventions:   Drug: Sorafenib (Nexavar, BAY43-9006);   Drug: Other Multikinase inhibitors
Sponsor:   Bayer
Recruiting - verified May 2017


Evaluation of Thyroid Stunning From a Diagnostic Dose of I-123


Condition:   Differentiated Thyroid Cancer
Intervention:   Drug: rhTSH
Sponsor:   University of Colorado, Denver
Recruiting - verified April 2017


A Phase II Study of MLN0128 in Metastatic Anaplastic Thyroid Cancer


Conditions:   Anaplastic Thyroid Cancer;   Thyroid Cancer
Intervention:   Drug: MLN0128
Sponsors:   Dana-Farber Cancer Institute;   Millennium Pharmaceuticals, Inc.
Recruiting - verified May 2017


Safety and Efficacy of Sorafenib in Patients With Advanced Thyroid Cancer: a Phase II Clinical Study


Condition:   Thyroid Cancer
Intervention:   Drug: Sorafenib
Sponsor:   Instituto Nacional de Cancerologia, Columbia
Recruiting - verified August 2016


Evaluation of Efficacy, Safety of Vandetanib in Patients With Differentiated Thyroid Cancer


Condition:   Differentiated Thyroid Cancer
Interventions:   Drug: Vandetanib (SAR390530);   Drug: Placebo
Sponsor:   Genzyme, a Sanofi Company
Active, not recruiting - verified January 2017


Study Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer


Condition:   Differentiated Thyroid Cancer
Interventions:   Drug: Selumetinib;   Drug: Placebo;   Drug: Radioactive Iodine Therapy
Sponsor:   AstraZeneca
Active, not recruiting - verified April 2017


IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients


Condition:   Thyroid Cancer
Intervention:   Radiation: I131 1.1 GBq
Sponsors:   University College, London;   Cancer Research UK
Recruiting - verified October 2016


Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer


Condition:   Thyroid Cancer
Interventions:   Drug: Everolimus;   Drug: Pasireotide;   Drug: Everolimus and Pasireotide
Sponsors:   Emory University;   Novartis
Active, not recruiting - verified April 2017


Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study


Condition:   Thyroid Cancer
Intervention:  
Sponsor:   National Cancer Institute (NCI)
Recruiting - verified March 17, 2017


RAD001 for Patients With Radioiodine Refractory Thyroid Cancer


Condition:   Thyroid Cancer
Intervention:   Drug: RAD001
Sponsors:   Dana-Farber Cancer Institute;   Massachusetts General Hospital;   M.D. Anderson Cancer Center;   Mount Sinai Hospital, New York;   Novartis
Active, not recruiting - verified January 2017


Lesion Dosimetry With 124-Iodine in Metastatic Thyroid Carcinoma


Condition:   Thyroid Cancer
Intervention:   Radiation: 131 I-iodine (131-I), 124 I-iodine (124-I)
Sponsors:   Memorial Sloan Kettering Cancer Center;   Gustave Roussy, Cancer Campus, Grand Paris
Active, not recruiting - verified March 2017


Thyroid Disease Serum Repository


Condition:   Thyroid Disease
Intervention:  
Sponsor:   University of Arkansas
Suspended - verified June 2016

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