Smoking Cessation

About Smoking Cessation Clinical Trials (Click to Open)

Join Clinical Trials for Smoking Cessation

Smoking CessationGeneral Purpose:

While smoking rates have declined nearly 50% in the past 50 years, the National Institute of Drug Abuse has found that 70.9 million Americans over the age of 12 currently use tobacco. This is of particular concern in individuals with mental disease, in which the rate is two to four times higher than the rest of the population.

Clinical trials for smoking cessation is therefore offers many trials to help those suffering from such mental illnesses as depression and posttraumatic stress disorder with smoking cessation. These programs include both behavioral and pharmaceutical interventions, aimed at helping people finally quit their deadly addiction.

To that end, much clinical research is also being conducted to determine what makes this addiction so hard to break. Given the wealth of information available in the media that makes clear just how unhealthy smoking is, there are many who are ready and willing to quit. However, it is incredibly hard to actually commit to quitting for a large portion of those who are addicted.

As a result, there is quite a bit of research attempting to elucidate the genetic component of addiction and smoking cessation. This may even give insight into the efficacy of certain pharmaceuticals based on a person’s genetic makeup.

Another focus is smoking prevention and secondhand smoke exposure prevention. Smoking is the leading cause of preventable death in America, so consider participating in a clinical trial to finally enable you to quit this nasty, deadly addiction.

What will Smoking Cessation Clinical Trials be like?

Your eligibility must first be evaluated during a screening phase to ensure that you are the right fit for the trial. The goal of these trials is often to help those who have been unable to quite smoking and to learn more about the factors behind smoking that make it so hard for many individuals to quit.

The trials are designed to provide participants with some benefit. These criteria are also clinical trials for smoking cessationthere to prevent you from experiencing any detrimental pharmaceutical interactions with another medication that you are taking. The researchers will therefore ask you to provide a very detailed medical history.

Clinical trials are also likely to select specific populations, and will thus select participants based upon such criteria. Moreover, they will likely require participants to smoke with a specific daily cigarette-smoking requirement, such as 10 cigarettes per day.

In genetic observational trials, potential participants will be given a genetic assessment to determine if there is any specific mutation present, or to retrospectively assess if there are common traits present within a large population of individuals that are less capable of smoking cessation.

Further blood testing may also be conducted, as well as breathing tests to determine lung capacity. Saliva samples for nicotine level assessments may also be conducted. You may be excluded from participation in interventional trials if you are concomitantly using other pharmacotherapies for smoking cessation.

Typical Smoking Cessation Clinical Trial Protocol:

In smoking cessation trials, if the main interventional method being tested is a new pharmaceutical, then you will likely be randomly assigned to a group that either receives a varying dose of the treatment or a control.

These trials will also often attempt to determine who benefits the most from such smoking cessation programs. Efficacy assessments will then be conducted to evaluate the changes in nicotine levels and smoking habits at certain time points throughout the duration of the trial.

A behavioral intervention trial may conduct a comparative analysis between different forms of exercise, psychotherapy, relaxation, etc. to determine which best facilitates smoking cessation and improves overall health.

Preventative clinical trials for smoking may involve educational programs for children and parents to promote healthy behaviors and prevent kids from smoking or inhaling secondhand smoke.

Other studies might take an observational approach and characterize the population based on health, quality of life, and genetics to perform a longitudinal study on smoking habits and quitting.

You will therefore undergo interviews and questionnaires so that the researchers can create a database from which to draw epidemiologic conclusions. All clinical trials will attempt to provide you personal benefit that improves your quality of life and promotes smoking cessation, while also using information provided by your trial experience to facilitate a decline in the number one cause of preventable deaths in America.

Suggested Search Terms:

“Pharmacotherapies for Smoking Cessation,” “Genetic Contribution to Smoking Cessation,” “Prevention of Second-Hand Smoke,” “Smoking Prevention in Youth,” “Behavioral Interventions for Smoking Cessation,” “Smoking Cessation”

Current Search Term:

“Smoking Cessation”

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Smoking Cessation Intervention


Condition:   Smoking Cessation
Interventions:   Behavioral: Spotlight on Smoke-Free Living: Mindsets and Decisions;   Drug: Transdermal Nicotine Patch
Sponsors:   University of Florida;   National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2017


Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer


Condition:   Smoking Cessation
Interventions:   Behavioral: Questionnaires;   Procedure: Low Dose Computed Tomography Scan;   Other: Shared Decision Making + Video;   Behavioral: Cessation Counseling;   Behavioral: Quitline;   Behavioral: Pharmacotherapy Discussion;   Drug: Nicotine Patch;   Drug: Anti-Smoking Drug;   Behavioral: Tobacco Treatment Program;   Other: Carbon Monoxide (CO) Level Test
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Not yet recruiting - verified May 2017


Cytisine Versus Varenicline for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Drug: Cytisine;   Behavioral: Behavioural support;   Drug: Varenicline
Sponsors:   University of Auckland, New Zealand;   Lakes District Health Board;   Brunel University
Not yet recruiting - verified May 2017


Clinical Trial of an Automated Smartphone Based Smoking Cessation Treatment


Condition:   Smoking Cessation
Interventions:   Behavioral: Treatment as Usual;   Behavioral: QuitGuide;   Behavioral: Smart-T
Sponsor:   University of Oklahoma
Not yet recruiting - verified May 2017


Short-bout Handgrip Exercise for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Video about exercise;   Behavioral: App about exercise;   Behavioral: Leaflet about exercise;   Behavioral: Video about diet;   Behavioral: App about diet;   Behavioral: Leaflet about diet
Sponsors:   The University of Hong Kong;   Tung Wah Group of Hospitals
Recruiting - verified May 2017


Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation


Condition:   Smoking Cessation
Interventions:   Device: rTMS Active 20Hz;   Device: rTMS Sham
Sponsors:   The City College of New York;   National Cancer Institute (NCI);   Virginia Tech Carilion Research Institute
Completed - verified June 2016


Trial of Treatment Protocol for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Other: Traditional & Complementary Medicine treatment;   Other: NRT, counselling
Sponsor:   Daejeon University
Recruiting - verified February 2017


Small Financial Incentives to Promote Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Standard Care + Financial Incentives;   Other: Standard Care
Sponsors:   University of Oklahoma;   National Cancer Institute (NCI);   The University of Texas Health Science Center, Houston;   William Marsh Rice University
Recruiting - verified March 2017


Worksite Phone Counseling for Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Nondirective smoking cessation coaching;   Behavioral: Directive smoking cessation coaching
Sponsor:   Washington University School of Medicine
Completed - verified October 2016


Evaluating the Efficacy of E-Cigarette Use for Smoking Cessation (E3) Trial


Condition:   Smoking Cessation
Interventions:   Other: Nicotine E-Cigarette;   Other: Non-Nicotine E-Cigarette;   Behavioral: Counseling
Sponsor:   McGill University
Recruiting - verified December 2016


Patient Navigation and Financial Incentives to Promote Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Intervention;   Other: Enhanced Traditional Care control
Sponsor:   Boston Medical Center
Active, not recruiting - verified March 2017


Genetically Informed Smoking Cessation Trial


Condition:   Smoking Cessation
Interventions:   Drug: Combination NRT (Nicotine patch, Nicotine lozenge);   Drug: Varenicline;   Drug: Placebo
Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
Recruiting - verified September 2016


Novel Smoking Cessation Drug for Schizophrenia


Condition:   Smoking Cessation
Interventions:   Drug: Active JNJ Drug;   Drug: Placebo Pill
Sponsors:   K.N. Roy Chengappa;   University of Pittsburgh;   National Institutes of Health (NIH);   Virginia Commonwealth University
Completed - verified March 2017


Evaluation of Deep Transcranial Magnetic Stimulation (DTMS) With the H-ADD Coil as an Aid to Smoking Cessation.


Condition:   Smoking Cessation
Interventions:   Device: Sham Treatment;   Device: Active dTMS Treatment
Sponsor:   Brainsway
Recruiting - verified February 2017


Smoking Cessation After Hospitalization for a Cardiopulmonary Illness


Condition:   Smoking Cessation
Interventions:   Behavioral: hypnotherapy;   Drug: Nicotine
Sponsor:   North Shore Medical Center
Completed - verified May 2017


Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.


Condition:   Smoking Cessation
Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Sponsor:   Pfizer
Completed - verified October 2016


Smoking Cessation With the Ottawa Model and SmartCard in Out-patient Respirology Clinic Setting


Condition:   Smoking Cessation
Interventions:   Behavioral: Ottawa Model with SmartCard;   Behavioral: Usual care
Sponsors:   Ottawa Hospital Research Institute;   Ottawa Heart Institute Research Corporation
Completed - verified November 2013


Smoking Cessation Study In Healthy Adolescent Smokers


Condition:   Smoking Cessation
Interventions:   Drug: Varenicline 1mg BID;   Drug: Varenicline 0.5mg BID;   Drug: Placebo
Sponsor:   Pfizer
Active, not recruiting - verified April 2017


Social Determinants and Smoking Cessation


Condition:   Smoking Cessation
Interventions:   Behavioral: Questionnaires;   Drug: Nicotine Patch Therapy;   Behavioral: Counseling Sessions
Sponsors:   M.D. Anderson Cancer Center;   Cancer Prevention Research Institute of Texas;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed - verified October 2016


Smoking Cessation in Hospitalized Smokers


Condition:   Smoking Cessation
Interventions:   Drug: Nicotine Patches;   Behavioral: Telephone Counseling;   Behavioral: Brief Hospital Counseling
Sponsors:   University of California, San Diego;   National Cancer Institute (NCI)
Completed - verified October 2016


Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging


Condition:   Smoking Cessation
Interventions:   Behavioral: Telephone Counseling;   Drug: Nicotine Patches
Sponsor:   University of California, San Diego
Completed - verified October 2016


Smoking Cessation for American Indians


Condition:   Smoking Cessation
Interventions:   Behavioral: All Nations Breath of Life (ANBL);   Behavioral: Nontailored program (NT);   Drug: Pharmacotherapy
Sponsors:   Won Choi, PhD, MPH;   National Cancer Institute (NCI)
Completed - verified March 2017


Determinants of Smoking Cessation Among Latinos


Condition:   Smoking Cessation
Interventions:   Drug: Nicotine Replacement Therapy (NRT);   Behavioral: Questionnaire;   Behavioral: Counseling;   Behavioral: Self-Help Materials
Sponsors:   M.D. Anderson Cancer Center;   National Institute on Minority Health and Health Disparities (NIMHD);   Department of Health and Human Services;   National Institutes of Health (NIH)
Completed - verified September 2016


An Integrated Approach to Smoking Cessation in Severe Mental Illness (SMI)


Condition:   Smoking Cessation
Intervention:   Behavioral: BTSCS
Sponsors:   University of Maryland;   National Institute of Mental Health (NIMH)
Completed - verified March 2017


Smoking Cessation Aid for Young Smokers


Condition:   Smoking Cessation
Intervention:   Behavioral: Smoking cessation
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed - verified December 14, 2006

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