Join Clinical Trials for Osteoarthritis
Osteoarthritis results in joint pain and reduced motion, thereby inhibiting activities of daily living. Because osteoarthritis is more than just aging of the joints, clinical research is currently testing improved detection mechanisms, genetic influence, interventional treatments, and educational programs to help people manage their osteoarthritis.
Clinical trials for osteoarthritis may be separated by location of osteoarthritic symptoms, such as hip and knee. Preventative clinical trials will evaluate the combined effects of interventional and educational preventative practices for older adults to improve risk factors for arthritis. Living with osteoarthritis means coping with the pain, so the aim of many clinical trials will be pain management.
Pain management trials will assess the benefits of different medications, exercise, stem cell transplantation, and other interventional measures. Many studies will attempt to improve the basic functioning that is impaired by osteoarthritis, and will use quality of life measures for evaluation.
Some studies may test improved diagnostic measures in order to expedite proper treatment and pain management. These trials are ultimately determined to improve your quality of life. If you are one of many Americans impeded by osteoarthritis, joining a clinical trial is a great way to find a new treatment and help further the body of knowledge about this common condition.
What will Clinical Trials for Osteoarthritis be like?
Before starting a trial, your eligibility will be evaluated through clinical tests and medical history to ensure that you are the right fit for the aim of the osteoarthritis trial. The goal is to improve your quality of life, so these inclusion criteria are intended to provide benefit and avoid wasting your time.
Moreover, this criteria is intended to prevent potentially detrimental interactions with another underlying condition or medication that you are taking. You will therefore need to provide the trial coordinators with a detailed medical history.
Clinical assessment of your osteoarthritis must be established, likely through radiographic evidence and a clinician’s diagnosis. If you wish to join a knee OA clinical trial, you will likely be assessed according to the Kellgren and Lawrence scale that ranges from 0 (normal) to 4 (severe). In any OA trial, you will need to provide details about any joint pain or stiffness that you are suffering from.
Typical Osteoarthritis Clinical Trial Protocol:
If the main interventional mechanism being tested is behavioral, such as an exercise program, you will be assigned to an exercise group or given an exercise regimen to follow. You will then be asked to report on your symptoms so that potential benefit can be evaluated.
Functioning will also be assessed at various time points to measure impact. Trials seeking new and improved diagnostic measures will ask you to undergo these new methods, such as magnetic resonance imaging (MRI). Pharmaceutical clinical trials will provide different treatment groups varying doses to assess the treatment’s effectiveness.
You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.
If a stem cell transplantation procedure is the interventional treatment, participants will be assigned to a group receiving the stem cells, to evaluate the feasibility and safety of this procedure.
Participants will then receive questionnaires to assess the efficacy of the procedure, and will also undergo quantitative MRI to determine if cartilage has been regenerated at specified time periods after the implantation of stem cells.
Suggested Search Terms:
Osteoarthritis Exercise Program, Pain Management in Osteoarthritis, Stem Cells Transplantation for Osteoarthritis, Coping Skills and Osteoarthritis, Osteoarthritis Prevention in Adults
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