About Osteoarthritis Clinical Trials (Click to Open)

Join Clinical Trials for Osteoarthritis

Clinical Trials for OsteoarthritisGeneral Purpose:

Osteoarthritis results in joint pain and reduced motion, thereby inhibiting activities of daily living. Because osteoarthritis is more than just aging of the joints, clinical research is currently testing improved detection mechanisms, genetic influence, interventional treatments, and educational programs to help people manage their osteoarthritis.

Clinical trials for osteoarthritis may be separated by location of osteoarthritic symptoms, such as hip and knee. Preventative clinical trials will evaluate the combined effects of interventional and educational preventative practices for older adults to improve risk factors for arthritis. Living with osteoarthritis means coping with the pain, so the aim of many clinical trials will be pain management.

Pain management trials will assess the benefits of different medications, exercise, stem cell transplantation, and other interventional measures. Many studies will attempt to improve the basic functioning that is impaired by osteoarthritis, and will use quality of life measures for evaluation.

Some studies may test improved diagnostic measures in order to expedite proper treatment and pain management. These trials are ultimately determined to improve your quality of life. If you are one of many Americans impeded by osteoarthritis, joining a clinical trial is a great way to find a new treatment and help further the body of knowledge about this common condition.

What will Clinical Trials for Osteoarthritis be like?

Before starting a trial, your eligibility will be evaluated through clinical tests and medical Clinical Trials for Osteoarthritishistory to ensure that you are the right fit for the aim of the osteoarthritis trial. The goal is to improve your quality of life, so these inclusion criteria are intended to provide benefit and avoid wasting your time.

Moreover, this criteria is intended to prevent potentially detrimental interactions with another underlying condition or medication that you are taking. You will therefore need to provide the trial coordinators with a detailed medical history.

Clinical assessment of your osteoarthritis must be established, likely through radiographic evidence and a clinician’s diagnosis. If you wish to join a knee OA clinical trial, you will likely be assessed according to the Kellgren and Lawrence scale that ranges from 0 (normal) to 4 (severe). In any OA trial, you will need to provide details about any joint pain or stiffness that you are suffering from.

Typical Osteoarthritis Clinical Trial Protocol:

If the main interventional mechanism being tested is behavioral, such as an exercise program, you will be assigned to an exercise group or given an exercise regimen to follow. You will then be asked to report on your symptoms so that potential benefit can be evaluated.

Functioning will also be assessed at various time points to measure impact. Trials seeking new and improved diagnostic measures will ask you to undergo these new methods, such as magnetic resonance imaging (MRI). Pharmaceutical clinical trials will provide different treatment groups varying doses to assess the treatment’s effectiveness.

You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.

If a stem cell transplantation procedure is the interventional treatment, participants will be assigned to a group receiving the stem cells, to evaluate the feasibility and safety of this procedure.

Participants will then receive questionnaires to assess the efficacy of the procedure, and will also undergo quantitative MRI to determine if cartilage has been regenerated at specified time periods after the implantation of stem cells.

Suggested Search Terms:

Osteoarthritis Exercise Program, Pain Management in Osteoarthritis, Stem Cells Transplantation for Osteoarthritis, Coping Skills and Osteoarthritis, Osteoarthritis Prevention in Adults

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Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis

Condition:   Osteoarthritis
Sponsors:   The Republican Research and Practical Center for Epidemiology and Microbiology;   Belarusian Medical Academy of Post-Graduate Education
Enrolling by invitation - verified May 2017

Self-administered Acupressure for Knee Osteoarthritis: A Pilot Randomized Controlled Trial

Condition:   Knee Osteoarthritis
Interventions:   Other: Self-acupressure;   Other: Knee health education
Sponsor:   The Hong Kong Polytechnic University
Not yet recruiting - verified May 2017

The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients

Condition:   Osteoarthritis Hand
Interventions:   Drug: Celecoxib 100 MG;   Drug: Celecoxib 200mg
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting - verified February 2017

Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee

Condition:   Osteoarthritis, Knee
Interventions:   Drug: YYD302 2ml;   Drug: YYD302 3ml;   Drug: Placebo 3ml
Sponsor:   Yooyoung Pharmaceutical Co.,Ltd.
Recruiting - verified November 2016

The Effectiveness of Kinesio Taping Method for Knee Osteoarthritis.

Condition:   Knee Osteoarthritis
Intervention:   Other: Taping application
Sponsors:   Lithuanian University of Health Sciences;   International Kinesio Taping association
Recruiting - verified March 2017

Evaluation of Amniotic Fluid Product in Knee Osteoarthritis

Condition:   Osteoarthritis of the Knee
Interventions:   Other: Amniotic Fluid 4.0ml dose;   Other: Amniotic Fluid 2.0ml dose;   Other: Placebo Control
Sponsor:   MiMedx Group, Inc.
Active, not recruiting - verified January 2017

Zushima Plaster for Treating Knee Osteoarthritis

Condition:   Osteoarthritis
Interventions:   Drug: Zushima plaster with high dose;   Drug: Zushima plaster with low dose;   Drug: Indometacin Cataplasms
Sponsors:   Guang'anmen Hospital of China Academy of Chinese Medical Sciences;   Beijing Hospital of Traditional Chinese Medicine;   Beijing Hospital;   Beijing Jishuitan Hospital;   Beijing Shijitan Hospital;   Shanghai Municipal Hospital of Traditional Chinese Medicine;   Gansu Provincial Hospital;   General Hospital of Beijing Military Area
Recruiting - verified October 2016

STepped Exercise Program for Knee OsteoArthritis

Condition:   Osteoarthritis, Knee
Interventions:   Behavioral: Stepped Exercise Program;   Behavioral: Arthritis Education
Sponsor:   VA Office of Research and Development
Recruiting - verified April 2017

Pain Coping Skills Training for African Americans With Osteoarthritis

Condition:   Osteoarthritis
Intervention:   Behavioral: Pain Coping Skills Training (CST)
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Recruiting - verified December 2016

Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee

Condition:   Osteoarthritis, Knee
Interventions:   Drug: YY1201 2ml;   Drug: Placebo 2ml;   Drug: YY1201 3ml;   Drug: Placebo 3ml
Sponsor:   Yooyoung Pharmaceutical Co.,Ltd.
Withdrawn - verified November 2016

The Effect of Intra-articular Pulsed Radiofrequency in Osteoarthritis

Condition:   Osteoarthritis
Intervention:   Device: pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)
Sponsor:   Tri-Service General Hospital
Withdrawn - verified November 2016

Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?

Condition:   Knee Osteoarthritis
Intervention:   Device: functional knee brace
Sponsor:   Shin Kong Wu Ho-Su Memorial Hospital
Active, not recruiting - verified January 2017

Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis

Condition:   Knee Osteoarthritis
Interventions:   Behavioral: Internet Based Exercise Training;   Behavioral: Physical Therapy
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Active, not recruiting - verified December 2016

Evaluating the Efficacy of Lateral Heel Wedges of Osteoarthritis of the Knee

Condition:   Knee Osteoarthritis
Interventions:   Other: Wedge Insert;   Other: Flat Insert
Sponsors:   HealthPartners Institute;   University of Minnesota - Clinical and Translational Science Institute;   Minnesota Medical Foundation
Active, not recruiting - verified February 2017

Efficacy of Radial Shockwave Therapy for Treatment of Pain in Knee Osteoarthritis

Condition:   Knee Osteoarthritis
Interventions:   Device: Extracorporeal Radial shockwaves;   Device: Placebo Radial Shockwaves
Sponsors:   Marta Imamura;   University of Sao Paulo
Completed - verified October 2016

Pain Expectations in Subjects With Osteoarthritis

Condition:   Osteoarthritis
Interventions:   Drug: Modafinil;   Drug: Gabapentin;   Drug: Placebo
Sponsor:   Wake Forest University Health Sciences
Recruiting - verified January 2017

Hydrotherapy Intervention in Elderly With Knee Osteoarthritis

Condition:   Knee Osteoarthritis
Interventions:   Other: Hydrotherapy intervention;   Other: Control group
Sponsor:   Universidad de Granada
Completed - verified November 2016

Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis)

Condition:   Hip Osteoarthritis
Interventions:   Biological: PRP;   Device: Hyaluronic Acid
Sponsor:   University of Colorado, Denver
Enrolling by invitation - verified August 2016

Survey of Osteoarthritis Real World Therapies (MK-0663-140)

Condition:   Osteoarthritis
Intervention:   Drug: Standard of care for treatment of osteoarthritis (OA) of knee(s)
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified March 2017

Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis Patients

Condition:   Osteoarthritis
Sponsor:   Zimmer Biomet
Completed - verified December 2012

Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

Condition:   Osteoarthritis
Interventions:   Drug: Methylprednisolone and Lidocaine;   Drug: Methylprednisolone and Lidocaine;   Drug: Placebo and Lidocaine
Sponsor:   Herbert Lindsley, MD
Completed - verified October 2016

Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis

Interventions:   Device: Agilus;   Device: Normal saline
Sponsor:   Cartiva, Inc.
Terminated - verified November 2016

A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee

Condition:   Osteoarthritis
Interventions:   Drug: SD-6010;   Drug: SD-6010;   Drug: Placebo
Sponsor:   Pfizer
Completed - verified November 2016

Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee

Condition:   Knee Osteoarthritis
Intervention:   Drug: balicatib (AAE581)
Sponsor:   Novartis Pharmaceuticals
Completed - verified March 2017

Prevention of Post-Traumatic Osteoarthritis (OA)

Condition:   Osteoarthritis
Interventions:   Procedure: Ankle distraction permitting motion;   Procedure: Ankle distraction without motion
Sponsors:   Ned Amendola;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed - verified March 2017

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