Osteoarthritis

About Osteoarthritis Clinical Trials (Click to Open)

Join Clinical Trials for Osteoarthritis

Clinical Trials for OsteoarthritisGeneral Purpose:

Osteoarthritis results in joint pain and reduced motion, thereby inhibiting activities of daily living. Because osteoarthritis is more than just aging of the joints, clinical research is currently testing improved detection mechanisms, genetic influence, interventional treatments, and educational programs to help people manage their osteoarthritis.

Clinical trials for osteoarthritis may be separated by location of osteoarthritic symptoms, such as hip and knee. Preventative clinical trials will evaluate the combined effects of interventional and educational preventative practices for older adults to improve risk factors for arthritis. Living with osteoarthritis means coping with the pain, so the aim of many clinical trials will be pain management.

Pain management trials will assess the benefits of different medications, exercise, stem cell transplantation, and other interventional measures. Many studies will attempt to improve the basic functioning that is impaired by osteoarthritis, and will use quality of life measures for evaluation.

Some studies may test improved diagnostic measures in order to expedite proper treatment and pain management. These trials are ultimately determined to improve your quality of life. If you are one of many Americans impeded by osteoarthritis, joining a clinical trial is a great way to find a new treatment and help further the body of knowledge about this common condition.

What will Clinical Trials for Osteoarthritis be like?

Before starting a trial, your eligibility will be evaluated through clinical tests and medical Clinical Trials for Osteoarthritishistory to ensure that you are the right fit for the aim of the osteoarthritis trial. The goal is to improve your quality of life, so these inclusion criteria are intended to provide benefit and avoid wasting your time.

Moreover, this criteria is intended to prevent potentially detrimental interactions with another underlying condition or medication that you are taking. You will therefore need to provide the trial coordinators with a detailed medical history.

Clinical assessment of your osteoarthritis must be established, likely through radiographic evidence and a clinician’s diagnosis. If you wish to join a knee OA clinical trial, you will likely be assessed according to the Kellgren and Lawrence scale that ranges from 0 (normal) to 4 (severe). In any OA trial, you will need to provide details about any joint pain or stiffness that you are suffering from.

Typical Osteoarthritis Clinical Trial Protocol:

If the main interventional mechanism being tested is behavioral, such as an exercise program, you will be assigned to an exercise group or given an exercise regimen to follow. You will then be asked to report on your symptoms so that potential benefit can be evaluated.

Functioning will also be assessed at various time points to measure impact. Trials seeking new and improved diagnostic measures will ask you to undergo these new methods, such as magnetic resonance imaging (MRI). Pharmaceutical clinical trials will provide different treatment groups varying doses to assess the treatment’s effectiveness.

You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.

If a stem cell transplantation procedure is the interventional treatment, participants will be assigned to a group receiving the stem cells, to evaluate the feasibility and safety of this procedure.

Participants will then receive questionnaires to assess the efficacy of the procedure, and will also undergo quantitative MRI to determine if cartilage has been regenerated at specified time periods after the implantation of stem cells.

Suggested Search Terms:

Osteoarthritis Exercise Program, Pain Management in Osteoarthritis, Stem Cells Transplantation for Osteoarthritis, Coping Skills and Osteoarthritis, Osteoarthritis Prevention in Adults

Current Search Term:

“Osteoarthritis”

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Feasibility of High Intensity Interval Training in Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Intervention:   Behavioral: High intensity interval training (HIIT)
Sponsors:   University of North Carolina, Chapel Hill;   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Not yet recruiting


Self-administered Acupressure for Knee Osteoarthritis: A Pilot Randomized Controlled Trial


Condition:   Knee Osteoarthritis
Interventions:   Other: Self-acupressure;   Other: Knee health education
Sponsor:   The Hong Kong Polytechnic University
Recruiting


The Effectiveness of Kinesio Taping Method for Knee Osteoarthritis.


Condition:   Knee Osteoarthritis
Intervention:   Other: Taping application
Sponsors:   Lithuanian University of Health Sciences;   International Kinesio Taping association
Recruiting


The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients


Condition:   Osteoarthritis Hand
Interventions:   Drug: Celecoxib 100 MG;   Drug: Celecoxib 200mg
Sponsor:   Chong Kun Dang Pharmaceutical
Recruiting


Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee


Condition:   Osteoarthritis, Knee
Interventions:   Drug: YYD302 2ml;   Drug: YYD302 3ml;   Drug: Placebo 3ml
Sponsor:   Yooyoung Pharmaceutical Co.,Ltd.
Recruiting


Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?


Condition:   Knee Osteoarthritis
Intervention:   Device: functional knee brace
Sponsor:   Shin Kong Wu Ho-Su Memorial Hospital
Active, not recruiting


Pain Coping Skills Training for African Americans With Osteoarthritis


Condition:   Osteoarthritis
Intervention:   Behavioral: Pain Coping Skills Training (CST)
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Active, not recruiting


Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee


Condition:   Osteoarthritis, Knee
Interventions:   Drug: YY1201 2ml;   Drug: Placebo 2ml;   Drug: YY1201 3ml;   Drug: Placebo 3ml
Sponsor:   Yooyoung Pharmaceutical Co.,Ltd.
Withdrawn


The Effect of Intra-articular Pulsed Radiofrequency in Osteoarthritis


Condition:   Osteoarthritis
Intervention:   Device: pulsed radiofrequency (Neurotherm NT1000, Neurotherm Inc., USA)
Sponsor:   Tri-Service General Hospital
Withdrawn


Intra-Articular Injections of Platelet-Rich Plasma in Knee Osteoarthritis: Unique Application Versus Triple Application


Condition:   Osteoarthritis
Interventions:   Biological: Platelet-Rich Plasma;   Behavioral: rehabilitation exercises
Sponsor:   Universidad Autonoma de Nuevo Leon
Unknown status


Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Interventions:   Behavioral: Internet Based Exercise Training;   Behavioral: Physical Therapy
Sponsors:   University of North Carolina, Chapel Hill;   Patient-Centered Outcomes Research Institute
Completed


Pain Expectations in Subjects With Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Drug: Modafinil;   Drug: Gabapentin;   Drug: Placebo
Sponsor:   Wake Forest University Health Sciences
Recruiting


Hydrotherapy Intervention in Elderly With Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Interventions:   Other: Hydrotherapy intervention;   Other: Control group
Sponsor:   Universidad de Granada
Completed


Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis)


Condition:   Hip Osteoarthritis
Interventions:   Biological: PRP;   Device: Hyaluronic Acid
Sponsor:   University of Colorado, Denver
Enrolling by invitation


Survey of Osteoarthritis Real World Therapies (MK-0663-140)


Condition:   Osteoarthritis
Intervention:   Drug: Standard of care for treatment of osteoarthritis (OA) of knee(s)
Sponsor:   Merck Sharp & Dohme Corp.
Completed


Biomarkers and Knee Osteoarthritis


Condition:   Knee Osteoarthritis
Intervention:   Behavioral: Lower limb muscle strengthening
Sponsors:   University of British Columbia;   Canadian Arthritis Network
Completed


Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab


Condition:   Osteoarthritis, Knee
Interventions:   Drug: Infliximab;   Drug: Placebo;   Drug: Standard of Care: Methylprednisolone acetate
Sponsors:   University of Kansas;   Centocor, Inc.
Completed


Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis Patients


Condition:   Osteoarthritis
Intervention:  
Sponsor:   Zimmer Biomet
Completed


Study to Evaluate the Digestive Tolerability of ART44 Versus ART®50 in Patients With Osteoarthritis of the Knee


Condition:   Knee Osteoarthritis
Interventions:   Drug: ART 44;   Drug: ART 50
Sponsor:   Laboratoires NEGMA
Unknown status


Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Drug: Methylprednisolone and Lidocaine;   Drug: Placebo and Lidocaine
Sponsor:   Herbert Lindsley, MD
Completed


Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis


Condition:   OSTEOARTHRITIS
Interventions:   Device: Agilus;   Device: Normal saline
Sponsor:   Cartiva, Inc.
Terminated


A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee


Condition:   Osteoarthritis
Interventions:   Drug: SD-6010;   Drug: Placebo
Sponsor:   Pfizer
Completed


Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Hip


Conditions:   Osteoarthritis;   Osteoarthritis, Hip
Interventions:   Drug: Naproxcinod;   Drug: Naproxen;   Drug: Placebo
Sponsor:   NicOx
Completed


A Study Of The Effects Of CB2 Compound Of GW842166 In Patients With Osteoarthritis


Condition:   Osteoarthritis
Interventions:   Drug: GW842166;   Drug: Placebo
Sponsor:   GlaxoSmithKline
Completed


Prevention of Post-Traumatic Osteoarthritis (OA)


Condition:   Osteoarthritis
Interventions:   Procedure: Ankle distraction permitting motion;   Procedure: Ankle distraction without motion
Sponsors:   Ned Amendola;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Completed

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