Migraines

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Clinical Trials for MigrainesGeneral Purpose

Migraines are a debilitating experience that can completely stop anyone in their tracks. Unfortunately, there is no complete cure as science has yet to uncover the precise cause. There are currently approaches to both prevent migraines and ease the resulting symptoms during one.

According to research, migraine experiences worsen over time and can even become a chronic condition. Given all that remains to be understood about this elusive and incredibly painful condition, clinical research is actively recruiting participants to help elucidate the mysteries behind migraines.

Determining the appropriate formulation of medication can help prevent and treat migraines, so that is the main focus of many clinical trials for migraines. Clinical research is therefore attempting to improve the quality of life of those afflicted with migraines.

Your participation in clinical trials for migraines will enable you to gain advanced access to new and improved treatments and help extend the body of knowledge about migraines for the many sufferers of this debilitating condition.

What will Clinical Trials for Migraines be Like?

Clinical trials for Migraines will conduct screenings of each potential participant, which will include a detailed medical history of migraines that is consistent with the International Headache Society (HIS). This may be with or without an aura (the associated visual disturbances).

Depending on the specific trial, the study doctor may request additional tests for each Clinical Trials for Migrainesindividual. The goal is to ensure that you are the proper fit for a trial. Researchers understand the great burden of experiencing migraines, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for both them and other patients struggling with this detrimental condition.

Inclusion criteria are intended to provide benefit and avoid wasting your time. Some trials may include interventional treatments that cannot be taken if a woman is pregnant or plans on becoming pregnant at any point throughout the duration of the trial.

Researchers will also likely require that you have no clinically significant abnormalities on neurological exams or clinical laboratory test results at the beginning of the trial. In order to be eligible for certain treatment groups, some trials may require potential participants to report a specified minimum number of migraines per month.

In some trials, you may have to taper and discontinue complete use of current preventative medications, while in others you may be able to rely on certain current methods should you experience a migraine during the length of the clinical trial.

Since migraines aren’t completely understood and there is no completely effective treatment available, there is an extensive range of interventional methods beings evaluated. As a result, you must make sure to pick a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail.

Typical Migraine Clinical Trial Protocol:

Given the imprecise understanding of this condition and the lack of a completely effective treatment, different trial protocols may vary greatly. Most interventional studies will randomly assign you to a group. In this group, you will participate in a treatment or a control for comparison.

Most interventional trials will assess the safety and efficacy of a pharmaceutical. This may include splitting participants into varying dosage groups that will run in parallel with specified check points throughout the trial to evaluate the proper dosage. Alternatively, these trials may compare different pharmaceuticals and a placebo, following a similar outline as the aforementioned dosage determination trial.

These may include an intra-oral medication, intranasal medication, oral medication, etc. Throughout these trials, participants will likely be asked to complete a diary of their migraines, including whether or not they experience an aura, the duration of any migraines, and the details of reliance upon a rescue medication (should they be allowed to use one).

Participants may also be required to attend a clinic for assessment and blood and urine sample collection. Other studies might follow a similar outline, but instead the treatment may involve a supplement, a receptor agonist, etc.

Suggested Search Terms:

Migraine Prevention, Migraine Symptom Treatment, Dose Ranging of Migraine Prophylactic, Migraine Study in Women, Migraine With or Without an Aura

Current Search Term:

“Migraines”

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A Study to Evaluate the Long-Term Safety of M207 in the Acute Treatment of Migraine


Condition:   Migraine
Intervention:   Drug: M207 Microneedle System
Sponsor:   Zosano Pharma Corporation
Not yet recruiting


Open Label Safety Study in Acute Treatment of Migraine


Condition:   Migraine
Intervention:   Drug: Rimegepant
Sponsor:   Biohaven Pharmaceutical Holding Company Ltd.
Recruiting


OnabotulinumtoxinA Injections in Chronic Migraine, Targeted to Sites of Pericranial Myofascial Pain


Condition:   Chronic Migraine
Intervention:  
Sponsor:   University Hospital, Limoges
Completed


MigraineManager: An Individualized Self-Management Tool for Adolescents With Migraine


Condition:   Migraine Disorders
Intervention:   Behavioral: MigraineManager: Individualized Self-Management Tool
Sponsor:   Children's Hospital Medical Center, Cincinnati
Not yet recruiting


Intracranial Pressure During Migraine


Condition:   Menstrual Migraine
Intervention:   Other: Intracranial pressure variations
Sponsor:   University Hospital, Clermont-Ferrand
Recruiting


Efficacy and Safety of IONIS-PKKRx for Preventive Treatment of Chronic Migraine


Condition:   Chronic Migraine
Interventions:   Drug: IONIS-PKKRx (ISIS 546254);   Other: Placebo
Sponsors:   Smith, Timothy R., M.D.;   Clinvest Research, LLC;   Ionis Pharmaceuticals, Inc.
Recruiting


Structural and Molecular Neuroplasticity in Migraine


Condition:   Migraine
Interventions:   Procedure: Pet Scan;   Procedure: MRI scan;   Procedure: Quantitative Sensory Testing (QST)
Sponsor:   University of Michigan
Completed


Investigation and Modulation of the Mu-Opioid Mechanisms in Migraine (in Vivo)


Condition:   Migraine
Interventions:   Device: Active Comparator;   Device: Sham Comparator
Sponsors:   University of Michigan;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting


A Safety and Efficacy Study to Evaluate AMG 334 in Migraine Prevention


Condition:   Migraine
Interventions:   Drug: AMG 334 Dose Level 1;   Drug: Placebo;   Drug: AMG 334 Dose Level 2;   Drug: AMG 334 Dose Level 3
Sponsor:   Amgen
Active, not recruiting


Study of Key Electro-acupuncture Technique on Migraine


Condition:   Migraine
Interventions:   Device: electro-acupuncture;   Drug: flunarizine hydrochloride
Sponsor:   Shanghai University of Traditional Chinese Medicine
Recruiting


Pharmacokinetics & Safety of Cambia® in Migraine With or Without Aura in 12-17 Year Olds


Condition:   Migraine
Intervention:   Drug: Diclofenac Potassium for Oral Solution
Sponsor:   Depomed
Completed


A Multicenter Assessment of ALD403 in Chronic Migraine


Condition:   Migraine Disorders
Interventions:   Biological: ALD403;   Biological: Placebo
Sponsor:   Alder Biopharmaceuticals, Inc.
Completed


Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine


Condition:   Migraine Disorders
Interventions:   Drug: nortriptyline;   Drug: Topiramate
Sponsor:   St. Louis University
Recruiting


Nutrition for Migraine Prevention


Condition:   Migraine Disorders
Intervention:   Other: Diet
Sponsors:   University of North Carolina, Chapel Hill;   National Center for Complementary and Integrative Health (NCCIH)
Recruiting


A Phase 2 Study to Evaluate the Efficacy and Safety of AMG 334 in Migraine Prevention


Condition:   Migraine
Interventions:   Drug: AMG 334;   Drug: Placebo
Sponsor:   Amgen
Active, not recruiting


Normobaric Oxygen (NBO) Therapy in Acute Migraine


Condition:   Migraine
Interventions:   Biological: Oxygen;   Biological: Room air
Sponsor:   Massachusetts General Hospital
Completed


Milnacipran for Migraine Pain


Condition:   Chronic Migraine
Interventions:   Drug: Milnacipran;   Drug: Placebo
Sponsor:   Timothy Smith
Completed


The Coherex FlatStent™ EF PFO Migraine Registry


Condition:   Patients With Migraine and PFO
Intervention:   Device: Transcatheter PFO Closure
Sponsor:   Coherex Medical
Terminated


Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?


Condition:   Migraine
Interventions:   Drug: Amitriptyline;   Drug: Topiramate
Sponsor:   Rambam Health Care Campus
Completed


Telcagepant for Prevention of Menstrually Related Migraine in Female Participants With Episodic Migraine (MK-0974-065)


Condition:   Migraine
Interventions:   Drug: Telcagepant;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed


A Study to Evaluate the Efficacy and Tolerability of Rizatriptan for Treatment of Acute Migraine (0462-087)


Condition:   Acute Migraine
Interventions:   Drug: rizatriptan;   Drug: Comparator: Placebo;   Drug: Comparator: Sumatriptan
Sponsor:   Merck Sharp & Dohme Corp.
Completed


Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)


Condition:   Migraine
Intervention:   Device: DC Stimulator (Transcranial Direct Current Stimulator)
Sponsor:   Beth Israel Deaconess Medical Center
Completed


Staccato Loxapine in Migraine (in Clinic)


Condition:   Migraine
Interventions:   Drug: Staccato Loxapine;   Drug: Staccato Placebo
Sponsor:   Alexza Pharmaceuticals, Inc.
Completed


Multiple Attacks Study to Compare the Efficacy and Safety of MK-0974 With Placebo for Acute Migraine (MK-0974-031)


Condition:   Migraines
Interventions:   Drug: Telcagepant 140 mg;   Drug: Talcagepant 280 mg;   Drug: Placebo
Sponsor:   Merck Sharp & Dohme Corp.
Completed


A Study Designed to Test the Effectiveness and Safety of Treating Patients With Lacosamide for Migraine Prophylaxis


Condition:   Migraine
Interventions:   Drug: Lacosamide;   Other: Placebo
Sponsor:   UCB Pharma
Completed

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