About Menopause Clinical Trials (Click to Open)

Join Clinical Trials for Menopause

Menopause Clinical TrialsGeneral Purpose:

Menopause is an exciting time in a woman’s life, but it comes with a host of uncomfortable symptoms that can negatively impact activities of daily living. Around two million women undergo menopause each year, and many ponder the benefit of taking hormone replacement therapy and other alternative treatment measures to help alleviate the symptoms associated with this major life change.

Clinical research is attempting to evaluate interventional methods for improving the quality of life of women during menopause. Such interventions may include alternative treatments like herbal supplements, medications, and behavioral programs.

If you are suffering from the symptoms brought on by menopause (climacteric symptoms), participating in a clinical trial is an excellent way to find an improved approach to living well with menopause and to positively impact the lives of other women who are currently going through, or have yet to undergo, menopause.

What will Menopause/Hot Flashes Clinical Trials be like?

Clinical trials for menopause and the associated symptoms will conduct screenings of each potential participant, which may include a physical exam, medical history, and clinical assessment of your symptoms.

Inclusion criteria are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.

Researchers understand the great burden of living with menopausal symptoms, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other women struggling with climacteric symptoms.

Since the most effective intervention for menopausal symptoms remains unclear, there is an extensive range of interventional methods beings evaluated. As a result, you must make sure to select a clinical trial that you feel comfortable participating in after reading the informed consent and learning about what it will entail.

This is particularly important in considering a trial that is testing hormonal replacement, as you should be aware of potential side effects and weigh the potential benefits. You might wish to consult your gynecologist before joining a clinical trial to discuss your options.

Typical Menopause/Hot Flashes Clinical Trial Protocol:

Given the inability of many women to find an escape from the uncomfortable symptoms Clinical trials for menopauseassociated with menopause (climacteric symptoms), there is a diverse array of clinical trials attempting to evaluate new interventional methods to improve the quality of life of women undergoing menopause.

Treatment methods may vary from hormone replacement to an alternative medicine approach. Interventional studies will randomly assign you to a group. In this group you will participate in a treatment or a control for comparison purposes. In hormone replacement trials, researchers may attempt to determine the optimal formulation and dosage of such hormones as estrogen and progestin.

Participants will therefore be assigned to different treatment groups based upon varying doses, and their symptoms will be evaluated at specified time points throughout the duration of the study. This information will then be used to compare formulations and doses in terms of their efficacy and safety in treating menopausal symptoms. Participants may be asked to self-report on their symptoms during the trial by using a standardized questionnaire and rating scale.

Interventional trials testing alternative medicine approaches, such as Chinese Medicine Therapy, will follow a similar outline, with treatment groups receiving an alternative therapy for the purpose of evaluating its efficacy and safety in treating climacteric symptoms.

A behavioral intervention trial may evaluate the benefit of some form of cognitive behavior therapy, such as applied relaxation, on the quality of life of women undergoing menopause. A comparison between standard therapeutic approaches and relaxation may be conducted, or the interventional method may be kept in comparison to a non-treated group.

These trials may ask women to report on their quality of life at specified time points during the treatment, as well as to keep diaries of symptoms including hot flashes. The trial will attempt to determine the most effective intervention for improving the climacteric symptoms that impact your quality of life.

Moreover, joining a clinical trial of this nature will give you access to new interventional methods that are not yet available, so there are many potential benefits of participating in clinical trials on menopause.

Suggested Search Terms:

Climacteric Symptoms and Menopause, Hormone Replacement Therapy for Menopausal Women, Alternative Medicine Approaches to Menopausal Symptoms, Interventional Methods for Treating Hot Flashes, Improving the Quality of Life for Women Undergoing Menopause

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An Educational Intervention Based on the Teach Back Method on Self-care Practice Among Menopausal Women

Condition:   Menopause
Intervention:   Other: An Educational Program
Sponsor:   Gonabad University of Medical Sciences

Evaluating a Cognitive Remediation Intervention for Women During the Menopausal Transition

Condition:   Menopause
Intervention:   Behavioral: Cognitive remediation
Sponsor:   St. Joseph's Healthcare Hamilton
Not yet recruiting

Clinical Evaluation of Effectiveness and Safety of Amberen and Smart B by Women With Climacteric Syndrome

Conditions:   Climacteric Syndrome;   Menopause
Interventions:   Dietary Supplement: Amberen;   Dietary Supplement: Smart B;   Dietary Supplement: Placebo
Sponsor:   I.M. Sechenov First Moscow State Medical University

Use of Estriol at Distal Third of Vagina Improving Coital Pain in Post-menopause Women

Conditions:   Dyspareunia;   Menopause;   Sexual Dysfunction
Interventions:   Drug: Estriol;   Drug: Distal estriol;   Drug: Vaginal Gel
Sponsor:   University of Sao Paulo
Not yet recruiting

MyHealtheVet to Enable Shared Decision Making Regarding Menopausal in Postmenopausal Women Veterans (MEANS)

Condition:   Menopause
Intervention:   Other: Menopause educational secure messaging
Sponsors:   Miami VA Healthcare System;   Pfizer

A Home-based Breathing Training on Menopausal Symptoms

Conditions:   Menopause;   Menopause Related Conditions
Intervention:   Behavioral: home-based breathing training
Sponsor:   Ministry of Science and Technology, Taiwan

Menopausal Sleep Fragmentation and Body Fat Gain

Condition:   Menopause
Interventions:   Drug: Leuprolide Acetate;   Other: Fragmented sleep
Sponsor:   Brigham and Women's Hospital

A Pooled Analysis of the Data From Two Studies of Ammonium Succinate for Menopausal Symptoms

Condition:   Menopause Related Conditions
Interventions:   Dietary Supplement: Ammonium succinate;   Other: Placebo
Sponsor:   I.M. Sechenov First Moscow State Medical University

The Effects of Lateralized Thermal Sleepwear on Sleep, Skin Temperature and Skin Moisture in Menopausal Women

Condition:   Menopause Related Conditions
Interventions:   Device: Sleepwear with Lateralized Thermal Characteristics;   Device: Sham-Lateralized Sleepwear
Sponsor:   St. Peter's Hospital, Albany, NY
Not yet recruiting

Efficacy Study of Progesterone Tablet in Post-menopausal Women

Condition:   Menopause
Intervention:   Drug: Progesterone
Sponsor:   IBSA Institut Biochimique SA
Active, not recruiting

Study to Evaluate the Effects of the Cooling Bolero in Women With Common Menopause Symptoms

Condition:   Menopause Symptoms
Intervention:   Device: Cooling Bolero
Sponsors:   Englewood Hospital and Medical Center;   Nanohealth, Inc.
Enrolling by invitation

The Efficacy of ACupuncture On Menopausal Symptoms (ACOM)

Condition:   Menopause
Intervention:   Procedure: Acupuncture
Sponsors:   University of Copenhagen;   Section of General Practice, University of Copenhagen;   Research Unit Of General Practice, Copenhagen;   Danish Society for Evidence Based Acupuncture (DSEA);   Idella Foundation;   University of Southern Denmark
Active, not recruiting

MENOS@Work Trial: A Self-help CBT Intervention for Working Women

Condition:   Menopause
Intervention:   Behavioral: self-help CBT intervention (SHCBT)
Sponsors:   King's College London;   University of Nottingham;   Wellbeing of Women

Cognitive Behavioral Therapy for Insomnia and Nocturnal Hot Flashes in Menopause

Conditions:   Menopause;   Insomnia;   Hot Flashes
Intervention:   Behavioral: CBT for Menopausal Insomnia (CBTMI)
Sponsors:   The University of Texas Medical Branch, Galveston;   National Institutes of Health (NIH);   National Institute of Nursing Research (NINR)

Behavioral Treatment of Menopausal Insomnia; Sleep and Daytime Outcomes

Condition:   Menopause
Interventions:   Behavioral: Cognitive Behavioral Therapy for Insomnia;   Behavioral: Sleep Education;   Behavioral: Sleep Restriction Therapy
Sponsors:   Christopher Drake;   National Institute of Nursing Research (NINR);   Wayne State University;   University of Michigan

Tibolone and Placebo in Adjunct to Antidepressant Medication for Women With Menopausal Depression

Condition:   Menopausal Depression
Intervention:   Drug: Tibolone
Sponsor:   The Alfred

Estrogen and Serotonin on Changing Brain Chemistry

Condition:   Menopause
Interventions:   Drug: estrogen patch;   Drug: Amino acids;   Drug: Placebo Patch;   Drug: Placebo pills
Sponsors:   University of Pennsylvania;   National Institute of Mental Health (NIMH)
Active, not recruiting

Cortisol Levels on Menopausal Symptoms - Ancillary (Addendum) Study to Protocol 16997

Condition:   Menopause
Intervention:   Procedure: ACTH
Sponsor:   Cedars-Sinai Medical Center

Pilot Study - Impact of Traditional Acupuncture on Menopause

Condition:   Menopause
Interventions:   Procedure: TA;   Other: AA;   Other: WC
Sponsor:   Cedars-Sinai Medical Center

Brain Imaging Study in Menopausal Women With and Without Major Depressive Disorder

Conditions:   Menopause;   Depression
Interventions:   Drug: MDD diagnosis and Estrogen treatment;   Drug: MDD diagnosis and Fluoxetine treatment;   Drug: MDD diagnosis with both Estrogen and Fluoxetine treatment;   Drug: No depression and estrogen treatment
Sponsor:   University of Pennsylvania

Placebo Controlled Study of Atomoxetine in the Treatment of Mild to Moderate Cognitive Difficulties in Menopausal Women

Conditions:   Menopause;   Cognitive Disturbances
Interventions:   Drug: atomoxetine;   Drug: placebo
Sponsors:   University of Pennsylvania;   Eli Lilly and Company

Investigation of the Usefulness of Omega 3 Vitamins in the Relief of Hot Flashes in Menopausal Women.

Conditions:   Hot Flashes;   Menopause
Interventions:   Dietary Supplement: Omega 3 fatty acid vitamins;   Dietary Supplement: Placebo capsules
Sponsor:   Christiana Care Health Services

Organochlorine Exposure in Relation to Timing of Natural Menopause

Condition:   Menopause
Sponsor:   National Institute of Environmental Health Sciences (NIEHS)

Bioidentical 'Natural' Hormone Evaluation in Early Menopause

Condition:   Menopause
Interventions:   Drug: Prempro, premarin, provera conjugated estrogens, medroxyprogesterone acetate;   Drug: Estradiol , estriol , progesterone;   Drug: estradiol,progesterone;   Drug: estriol, progesterone
Sponsors:   Jeanne Drisko, MD, CNS, FACN;   Private Foundation through KU Endowment;   University of Kansas

Bleed Free Treatment of Menopausal Symptoms With New Ultra Low Dose Hormonal Combinations

Conditions:   Menopause;   Menopausal Vasomotor Symptoms
Interventions:   Drug: 0.5 mg estradiol / 0.1 mg norethisterone acetate (NETA);   Drug: 0.5 mg estradiol / 0.25 mg norethisterone acetate (NETA);   Drug: placebo
Sponsor:   Novo Nordisk A/S

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