Hypertension (HBP)

About Hypertension (HBP) Clinical Trials (Click to Open)

Join Clinical Trials for Hypertension

Clinical Trials for HypertensionGeneral Purpose:

High blood pressure (HBP) is a common condition affecting almost one third of America and increases an individual’s risk for developing such serious health problems as heart disease and heart failure. There will be different trial purposes depending on the stage of HBP.

For example, if you are pre-hypertensive, clinical trials will be targeted at preventing your condition from developing into stage 1 or 2 HBP. Many questions remain about the development of HBP and treatments, so clinical research aims to learn more about HBP.

Some studies are trying to determine the potential affects of HBP and treatments for HBP on brain functioning in children. There are many trials trying to uncover new and improved behavioral interventions for treating HBP.

Observational studies conducted to expand our understanding of the underlying epidemiology of HBP are attempting to look at the role that stress, SES, ethnicity, and other related factors play on blood pressure. There is also a great deal of research being conducted on the potential positive impact of medications and therapeutic treatments on controlling blood pressure.

By taking part in a clinical trial for hypertension (HBP), you will be among the first to obtain new treatments that may improve your health and quality of life. You will also be helping improve the scientific body of data surrounding this widespread condition.

What will Clinical Trials for Hypertension be like?

These trials intend to learn more about HBP, to facilitate prevention and treatment. Before joining a clinical trial, researchers will first assess your eligibility for helping achieve that end. You will go through a screening phase to ensure that you are an appropriate participant for the aims of the trial. Inclusion criteria are intended to provide benefit and avoid wasting your time.

They are also put in place to avoid any risk of a detrimental interaction between a behavioral or pharmaceutical intervention and an existing condition or medication. The researchers will therefore ask you to provide a very detailed medical history and perform clinical assessments to learn the state of your condition.

They will likely need such baseline information as height, weight, BMI, and may require urine and blood samples. Observational studies will likely have certain background restrictions for inclusion, such as ethnicity or age, in order to focus on certain epidemiologic trends.

Interventional studies will first require participants to undergo in depth screening, including blood pressure measurements. These inclusion criteria intend to determine if you are a good candidate for various forms of intervention, from behavioral to pharmaceutical.

Typical Hypertension Clinical Trial Protocol:

As with all clinical research, the trial protocol will depend upon the condition phase beingClinical Trials for Hypertension studied, as well as the treatment or observation being measured. Interventional trials evaluating a pharmaceutical will first randomly assign participants to different groups, either receiving a varying dose of a drug or a placebo.

Participants will then receive follow up assessments of blood pressure, metabolic factors, cardiovascular risk, etc. at specified time points throughout the duration of the study. While participating in these interventional studies, you will receive cardiovascular care and monitoring. Observational studies conducted to evaluate environmental risk factors, such as stress, will monitor your physiological functioning.

This might include spending nights at an associated clinical research hospital for sleep monitoring to obtain breathing rates and various physical movements. Blood pressure at a resting state and while performing certain activities will also help enhance scientific knowledge about HBP.

Given the impact of behavior on HBP, participants in behavioral intervention trials will undergo relevant baseline assessments, and after beginning a treatment (such as dietary changes and/or exercise) will continuously receive physiological monitoring to assess the benefit of the intervention being studied.

All clinical trials will attempt to provide you personal benefit that improves your quality of life, while also using information provided by your trial experience for the betterment of the many Americans struggling with HBP.  

Suggested Search Terms:

Impact of Stress on High Blood Pressure, Relationship Between Ethnicity and Blood Pressure, Controlling High Blood Pressure with Medication, Benefit of Exercise on High Blood Pressure, High Blood Pressure in Children

Current Search Term:

“hypertension”

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Uncontrolled Hypertension Management (TEAM-HTN)


Condition:   Uncontrolled Hypertension
Interventions:   Other: Clinical Decision Software - provider portal;   Other: Clinical Decision Software - patient portal
Sponsors:   Madigan Army Medical Center;   Telemedicine & Advanced Technology Research Center;   Analytics4Medicine, Inc.
Recruiting


Validity of 1BPM for Diagnosis of Hypertension


Condition:   Hypertension
Interventions:   Diagnostic Test: 1-hour blood pressure monitoring (1BPM);   Diagnostic Test: 24-hour ambulatory blood pressure monitoring (ABPM);   Diagnostic Test: Office blood pressure measurement (OBPM);   Diagnostic Test: Home blood pressure monitoring (HBPM)
Sponsors:   Consorci d'Atenció Primària de Salut de l'Eixample;   Instituto de Salud Carlos III
Recruiting


New Biomarkers and Difficult-to-treat Hypertension


Condition:   Hypertension
Intervention:  
Sponsors:   University Hospital Inselspital, Berne;   University of Zurich
Completed


Piloting Healthcare Coordination in Hypertension


Condition:   Hypertension
Intervention:   Device: optima4BP medication optimization
Sponsors:   Optima Integrated Health;   University of California, San Francisco
Completed


Comparison of Optimal Hypertension Regimens


Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Lisinopril;   Drug: Amiloride;   Drug: Chlortalidone
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Medical Research Council
Recruiting


Spinal Cord Stimulation to Treat Hypertension


Condition:   Hypertension
Intervention:   Device: Precision Spectra System
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting


Prevalence of Masked Hypertension in Nephrological Patients


Condition:   Masked Hypertension
Intervention:   Other: Comparison ABPM with OBPM
Sponsor:   Waid City Hospital, Zurich
Recruiting


A Randomized Controlled Trial of Sertraline in Paroxysmal Arterial Hypertension


Condition:   Hypertension
Interventions:   Drug: Sertraline;   Drug: Placebo
Sponsors:   University Hospital Olomouc;   Brno University Hospital;   St. Anne;   University Hospital Ostrava;   Tomas Bata Hospital, Czech Republic;   Prerov Hospital;   Valasske Mezirici Hospital;   Thomayerova Teaching Hospital;   Vsetin Hospital
Not yet recruiting


Treatment of Hypertension In Adults With ThiaZIDES: Pragmatic Trial Pilot Study


Condition:   Hypertension
Intervention:   Behavioral: HCTZ prescription conversion to chlorthalidone
Sponsors:   HealthPartners Institute;   Kaiser Permanente
Completed


Corever in the Treatment of Hypertension


Condition:   Hypertension
Intervention:   Drug: Corever
Sponsor:   TSH Biopharm Corporation Limited
Completed


Chronic Hypertension and Pregnancy (CHAP) Project


Condition:   Hypertension
Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Gunderson Health System;   Aurora Research Institute;   Beaumont Hospital;   University of Colorado, Denver
Recruiting


Treatment of Resistant Hypertension by Prevention of T-Cell Co-Stimulation


Condition:   Hypertension
Interventions:   Drug: Abatacept;   Drug: Placebo
Sponsors:   Vanderbilt University Medical Center;   Bristol-Myers Squibb
Terminated


Evaluation of Quality of Care - Multi-disciplinary Risk Assessment and Management Programme for Patients With Hypertension, HA (QoC RAMP-HT)


Condition:   Hypertension
Intervention:  
Sponsors:   The University of Hong Kong;   Hospital Authority, Hong Kong
Completed


The Role of Gut Microbiota in Hypertension


Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsors:   University of Florida;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting


Controlling Blood Pressure in Treatment Resistant Hypertension: A Pilot Study


Condition:   Hypertension
Interventions:   Drug: Renin treatment-guided Therapeutics;   Other: Referral Hypertension specialist;   Drug: Aldosterone Antagonist
Sponsors:   Medical University of South Carolina;   University of South Carolina
Completed


Conditioned Pharmacotherapeutic Effects in Hypertension


Condition:   Hypertension
Intervention:   Drug: carvedilol
Sponsor:   University of Rochester
Recruiting


Effect of Intense vs. Standard Hypertension Management on Nighttime Blood Pressure - an Ancillary Study to SPRINT


Condition:   Hypertension
Interventions:   Other: Intensive BP Arm;   Other: Standard BP arm
Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   Wake Forest University;   Louis Stokes VA Medical Center;   University of Pennsylvania;   Carolinas Medical Center;   Mayo Clinic;   University of Utah;   Vanderbilt University;   University of Alabama at Birmingham;   VA Medical Center, Houston;   Memphis VA Medical Center;   Washington D.C. Veterans Affairs Medical Center
Enrolling by invitation


A Study of Safety and Efficacy in MK-0954A Combination in Participants With Hypertension (MK-0954A-373 AM3)


Condition:   Hypertension
Intervention:   Drug: Losartan 50 mg / HCTZ 12.5 mg
Sponsor:   Merck Sharp & Dohme Corp.
Completed


Trial Using Motivational Interviewing Positive Affect and Self-Affirmation in Hypertension (TRIUMPH)


Condition:   Hypertension
Interventions:   Behavioral: Positive Affect/Self-Affirmation/Motivational Interviewing;   Behavioral: Educational and Behavioral
Sponsors:   Weill Medical College of Cornell University;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed


Chiropractic for Hypertension in Patients


Condition:   Hypertension
Interventions:   Other: Spinal Manipulation;   Other: Sham Spinal Manipulation
Sponsor:   Palmer College of Chiropractic
Completed


Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study


Condition:   Hypertension
Intervention:   Drug: Lisinopril, Atenolol
Sponsors:   Brigham and Women's Hospital;   University of Utah
Active, not recruiting


Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)


Condition:   Hypertension
Intervention:   Drug: Valsartan + Amlodipine besilate
Sponsor:   Novartis
Completed


Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential Hypertension


Condition:   Hypertension
Intervention:   Drug: Aliskiren
Sponsor:   Novartis
Completed


SPP100 (Aliskiren) Regimen in Patients With Severe Hypertension


Condition:   Hypertension
Intervention:   Drug: Aliskiren
Sponsor:   Novartis
Completed


Efficacy and Safety of Aliskiren and Atenolol in Adults (>18) With Mild to Moderate Hypertension


Condition:   Hypertension
Intervention:   Drug: Aliskiren
Sponsor:   Novartis
Completed

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