Heart Disease

About Heart Disease Clinical Trials (Click to Open)

Join Clinical Trials for Heart Disease

Clinical Trials for Heart DiseaseGeneral Purpose:

Heart disease refers to the many diseases affecting the heart. From congenital heart defects to coronary heart disease, there are many ongoing clinical trials for every form of heart disease.

Many forms of heart disease can actually be prevented or treated through behavioral interventions, so there are clinical trials attempting to evaluate prevention and treatment techniques.

There are also trials attempting to determine the prevalence of heart disease within various demographics to gain a better understanding of the epidemiology of this common condition.

Ultimately, clinical trials for heart disease are attempting to improve the quality of life of those afflicted with heart disease and to prevent those with increased risk from developing heart disease.

What will Heart Disease Clinical Trials be like?

Your eligibility must first be evaluated during a screening phase to ensure that you are the right fit for a heart disease trial. The goal of these trials is to improve the quality of life of those with heart disease, so inclusion criteria are intended to provide this benefit and avoid wasting your time.

Inclusion criteria are in place to avoid any risk from detrimental pharmaceutical interactions with another medication that you are taking. The researchers will therefore ask you to provide a very detailed medical history. In preventative trials, participants will be given a screening for heart disease risk factors.

Interventional trials will attempt to determine if you are an appropriate fit for a diverse array of new and improved treatment methods.

Typical Heart Disease Clinical Trial Protocol:

If the main interventional method being tested is a new pharmaceutical, you will be randomly assigned to a group that either receives the treatment or a placebo. To evaluate this intervention, participants will be asked to visit for follow up clinical assessments.Clinical Trials for Heart Disease

Behavioral intervention trials, such as exercise and dietary changes, will assign participants to different groups receiving various treatments or a standard control routine. Throughout the trial each group will be asked to attend follow up visits and testing to evaluate the success of the program.

Baseline measures of heart disease will be taken at the beginning of the trial, such as multi-detector computed tomographic angiography in coronary heart disease, for comparative monitoring purposes during checkpoints in the rest of the trial.

Studies aimed at enhancing the understanding of the various types of heart disease will request many questionnaires about an individual’s health and medical conditions, as well as physical examinations, clinical tests, and interviews.

These studies will help to provide a database of information for researchers to draw conclusions from to help make epidemiologic connections between risk factors and heart disease. Preventative trials will randomly assign participants to a group that will either receive the potential preventative treatment or a placebo.

Your participation in such trials provides critical insight into how this disease develops in at-risk individuals. Participation in all clinical trials for heart disease will enable researchers to improve the lives of those afflicted with heart disease and help prevent heart disease in others.

Suggested Search Terms:

Coronary Heart Disease, Cardiovascular Disease Screening, Genetics of Congenital Heart Defects, Women at Risk for Heart Disease, Exercise and Heart Disease

Current Search Term:

“Heart Disease”

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Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)


Condition:   Heart Disease Congenital
Interventions:   Other: Exposure of interest: Brain MRI;   Other: Exposure of interest: neurodevelopmental assessments
Sponsors:   Children's Hospital Medical Center, Cincinnati;   National Heart, Lung, and Blood Institute (NHLBI);   Pediatric Cardiac Genomics Consortium
Not yet recruiting - verified March 2017


Valvular Heart Disease Registry Study in Second Affiliated Hospital of ZheJiang University


Condition:   Valvular Heart Disease
Intervention:  
Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting - verified December 2016


Assessing Neurodevelopment in Congenital Heart Disease.


Condition:   Congenital Heart Disease
Interventions:   Procedure: Sonography;   Device: Magnetic Resonance Imaging;   Other: Bailey Test;   Procedure: Surgical intervention;   Procedure: Brain monitoring;   Procedure: cord blood sample
Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   Hospital Sant Joan de Deu;   Hospital Universitario La Paz;   Hospital Universitario 12 de Octubre;   Hospital General Universitario Gregorio Marañon;   Institut Universitari Dexeus
Recruiting - verified October 2016


Surgery and Transcatheter Intervention for Structural Heart Diseases


Condition:   Data Collecting and Analyzing of Different Treatment of Structural Heart Diseases
Intervention:  
Sponsors:   Xijing Hospital;   Fu Wai Hospital, Beijing, China;   Beijing Anzhen Hospital;   Wuhan Union Hospital, China
Recruiting - verified September 2016


Study on the Relationship Between Maternal Exposure to Environmental Factors and Fetal Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:  
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Not yet recruiting - verified September 2016


Northwest Adult Congenital Heart Disease Observatory


Condition:   Congenital Heart Disease
Intervention:   Other: description
Sponsor:   University Hospital, Caen
Not yet recruiting - verified September 2016


Mobile Health in Structural Heart Disease


Conditions:   Rheumatic Heart Disease;   Heart Diseases
Interventions:   Device: mHealth;   Other: Standard-Care
Sponsor:   Sri Sathya Sai Institute of Higher Medical Sciences
Completed - verified August 2016


Exercise Training in Grown-up Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:   Behavioral: exercise training
Sponsor:   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting - verified July 2016


Brain Function in Children With Congenital Heart Disease (CHD)


Condition:   Congenital Heart Disease
Intervention:  
Sponsors:   Bea Latal;   University of Zurich;   Mäxi Foundation
Enrolling by invitation - verified June 2016


Biventricular Pacing in Children After Surgery for Congenital Heart Disease


Condition:   Congenital Heart Disease (CHD)
Intervention:   Other: Biventricular pacing
Sponsor:   The Hospital for Sick Children
Completed - verified June 2016


Peri-conception Key Nutritional Factors and Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:   Other: observation
Sponsor:   Children's Hospital of Fudan University
Recruiting - verified May 2017


A Partnership to Translate an Evidence-based Intervention (Take Heart) for Vulnerable Older Adults With Heart Disease


Condition:   Heart Diseases
Intervention:   Behavioral: Take Heart
Sponsors:   University of Michigan;   National Institute on Aging (NIA);   Detroit Medical Center;   Detroit Area Agency on Aging
Recruiting - verified January 2017


Rheumatic Heart Disease Study in Lusaka


Condition:   Rheumatic Heart Disease
Intervention:  
Sponsors:   University of Zambia;   University of Cape Town;   Novartis
Completed - verified November 2016


Infant Nasal Nitric Oxide Levels in Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:   Device: Measurement of nasal Nitric Oxide level
Sponsors:   University of Alberta;   Women and Children's Health Research Institute, Canada
Recruiting - verified May 2017


Quality of Life in Young Adults With Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:   Other: no intervention
Sponsor:   University Children's Hospital, Zurich
Completed - verified June 2016


Biventricular Pacing in Children With Congenital Heart Disease


Condition:   Congenital Heart Disease (CHD)
Intervention:   Device: Biventricular Pacing (BiVp)
Sponsor:   The Hospital for Sick Children
Recruiting - verified April 2017


National Congenital Heart Disease Audit


Condition:   Congenital Heart Disease (CHD)
Interventions:   Procedure: Cardiac Surgery;   Procedure: Therapeutic cardiac catheterisations procedures
Sponsors:   University College, London;   Society for Cardiothoracic Surgery in Great Britain & Ireland;   British Congenital Cardiac Association
Recruiting - verified October 2016


Risk Factors for Acquired Cardiovascular Disease in Adults With Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:  
Sponsor:   Stanford University
Enrolling by invitation - verified April 2017


RhEumatiC Heart diseAse Genetics


Condition:   Rheumatic Heart Disease
Intervention:   Genetic: Next generation sequencing
Sponsors:   Brigham and Women's Hospital;   National University, Rwanda
Recruiting - verified July 2016


Assessment of the Efficacy of the First Aspirin Dose in Children Undergoing Surgery for Congenital Heart Disease (CHD) Who Require Post-operative Antiplatelet Therapy


Condition:   Congenital Heart Disease
Intervention:  
Sponsor:   University of Colorado, Denver
Active, not recruiting - verified August 2016


The Genetic Basis of Congenital Heart Disease in Africa


Conditions:   Congenital Heart Disease;   Heart Disease
Intervention:  
Sponsors:   National Human Genome Research Institute (NHGRI);   University of Lagos, Nigeria;   Uganda Heart Institute, Kampala, Uganda
Recruiting - verified July 22, 2016


Accuracy of Peripheral Pulse Oximetry Versus Arterial Co-oximeter in Children With Cyanotic Heart Disease


Condition:   Cyanotic Heart Disease
Intervention:  
Sponsor:   Stanford University
Completed - verified March 2017


Quality of Life Among Children With Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:  
Sponsor:   University Hospital, Montpellier
Completed - verified August 2016


Genetics of Congenital Heart Disease


Condition:   Congenital Heart Disease
Intervention:   Other: Blood Sample Collection
Sponsors:   Nationwide Children's Hospital;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2017


Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery


Condition:   Congenital Heart Disease
Interventions:   Drug: Phenoxybenzamine;   Other: Standard surgical approach
Sponsor:   Vanderbilt University
Withdrawn - verified April 2017

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