Join Clinical Trials for Depression
Living with depression can negatively impact all aspects of your life. While current treatments help some patients, not all are able to benefit from them. Clinical trials for depression are trying to bridge the gap in treatment so that there is hope for each and every patient.
Past research indicates that genes may contribute to the efficacy of antidepressants. Current clinical trials are therefore trying to decipher the effect that genes have on an individual’s response to treatment, which will facilitate improved treatment methods.
The role of glutamate levels in the brain is another key focus of depression research, as glutamate tends to be reduced in the brains of those with depression. Studies would now like to evaluate how various antidepressants affect glutamate levels in the brain.
Other trials may assess the benefit of different behavioral interventions, such as combined psychotherapy and illness management. In addition to efficacy trials, there are also many observational trials intending to develop new techniques to characterize the physiological changes that are indicative of depression.
Such studies will enhance the ability to assess the effects that depression has on patients, to improve the ability to treat depression.
What are Clinical Trials for Depression like?
Clinical trials for depression will conduct screenings of each potential participant, which may include a physical exam, medical history, and blood and urine tests. You will be asked to report on your mood, feelings of depression, and any family history of depression.
Depending on the specific trial, the study doctor may request additional tests for each individual. The goal is to ensure that you are the proper fit for a trial. Researchers understand the impedance of living with depression, so they aim to select participants that will gain a benefit from taking part in the trial, ideally for them and other patients struggling with this detrimental condition.
Inclusion criteria are intended to provide benefit and avoid wasting your time. They are also put in place to avoid any risk, which could result if, for example, the trial were assessing a new pharmaceutical treatment that had detrimental interactions with another medication that you are taking.
Typical Trial Protocol for Clinical Trials for Depression:
Interventional studies will vary depending upon the form of depression, such as major depressive disorder (MDD), depression related to pregnancy, depression in geriatric populations, etc.
Clinical trials for MDD will likely provide treatment groups with an antidepressant for one leg of the trial, during which time they will systematically be assessed through questionnaires and clinician reports to evaluate any changes in the symptoms.
Other parts of these trials may include physiological assessment, with such techniques as magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS). Clinical trials for depression during and after pregnancy may involve some form of behavioral intervention, such as psychotherapy.
Depression is one of the most common complications during pregnancy, and it can have detrimental health effects not only on the mother, but also on the baby. These trials are therefore integral to ensuring a healthy life for babies of mothers suffering from depression, particularly because it is quite hard to diagnose due to the overlap with typical pregnancy symptoms.
Participants in these trials will be assigned to interpersonal psychotherapy throughout pregnancy and in the months following, with periodic evaluations. Clinical trials targeting depression among an elderly group from granny nannies population often employ behavioral interventions, such as illness management.
Participants will be assigned to different management programs or psychotherapy groups, with symptom assessments scheduled at specific time intervals. Some clinical trials are meant specifically for healthy individuals without any history of depressive disorders, intended to develop new diagnostic assessments to better understand this illness. Studies of this nature will likely assign healthy participants to different technique groups, such as MRI and neuropsychological testing groups.
Suggested Search Terms:
Genetics and Major Depressive Disorder, Depression and Pregnancy, Treating Depressed Elders, Effects of Psychotherapy on Depression, Development of Magnetic Resonance Imaging Techniques for Depressive Disorders