Allergies – General

About Allergies – General Clinical Trials (Click to Open)

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Allergy Clinical TrialsGeneral Purpose:

The purpose of allergy clinical trials will be to desensitize the immune systems of those fighting allergies to ideally reach tolerance of the allergen. Studies also intend to gain a better understanding of how allergens affect the immune system, which should facilitate enhanced treatment measures.

Moreover, food allergy trials often examine the role of white blood cells in disease. To prevent allergic reactions from food allergies, industries also run trials on large groups to determine the minimum eliciting dose of the allergic response.

What is a typical Allergy clinical trial like?

Trial participants will undergo screening that involves a physical examination and medical history. Blood samples will be collected to determine each individual’s sensitivity to the allergens being studied. Participants may also be given allergy skin tests. 

Typical Trial Protocol for Allergy Clinical Trials:

In studies targeting the desensitization of the immune response, participants may receive an extended period of sublingual immunotherapy. This immunotherapy is designed to develop an individual’s tolerance to the allergen being tested by placing a custom mixed solution under the participant’s tongue on a daily basis.

These trials may be quite lengthy, as prior research indicates that this form of immunotherapy takes 3 to 5 years for effective results. Developed tolerance of the allergen will be assessed at varying time points throughout the study.

In allergen eliciting dose trials, participants may receive varying levels of allergens in studies targeted at determining the minimum eliciting doses. Participants will first receive a baseline challenge, which may then be repeated with the addition of extrinsic factors (such as exercise) to determine the role of external factors on food allergies.

You should also note that as with any clinical trial, it is possible that you will be randomly selected for the placebo group. You would therefore undergo the same procedures as the treatment group without receiving the actual treatment being tested.

Suggested Search Terms:

Food Allergies, Peanut Hypersensitivity, Asthma and Allergies, Sublingual Immunotherapy for Allergies, Pediatric Allergies



Staff Management About Food Allergy Into ResTaurants


Condition:   Food Allergy
Intervention:  
Sponsor:   Centre Hospitalier Régional Metz-Thionville
Completed


The Basophil Activation Test as a Diagnostic Tool in Pediatric Food Allergy


Condition:   FOOD ALLERGY
Intervention:   Diagnostic Test: The basophil activation test (BAT)
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting


Longitudinal Follow-up Study for Food Allergies


Condition:   Food Allergy
Intervention:   Other: Immunotherapy
Sponsor:   Stanford University
Enrolling by invitation


Precision Allergy: Separate Allergies to Male and Female Dogs


Condition:   Allergy; Dander
Interventions:   Diagnostic Test: Male dog;   Diagnostic Test: Female dog
Sponsor:   Copenhagen Studies on Asthma in Childhood
Recruiting


Registry of Food Allergy Oral Immunotherapy Treatment


Condition:   Food Allergy
Intervention:  
Sponsor:   Food Allergy Support Team
Not yet recruiting


Placebo-Controlled Study to Investigate ANB020 Activity in Adult Patients With Peanut Allergy


Condition:   Peanut Allergy
Interventions:   Drug: ANB020;   Drug: Placebo
Sponsor:   AnaptysBio, Inc.
Recruiting


Association Between Asthma and Food Allergy


Conditions:   Food Allergy Suspected;   Food Allergy Proved
Intervention:   Other: Pulmonary function test
Sponsor:   University Hospital, Montpellier
Recruiting


Impact of Infant Formula on Resolution of Cow's Milk Allergy


Condition:   Milk Allergy
Interventions:   Dietary Supplement: Lactobacillus GG;   Dietary Supplement: Extensively Hydrolyzed Casein Formula;   Dietary Supplement: Amino Acid Formula
Sponsors:   Massachusetts General Hospital;   Mead Johnson Nutrition
Terminated


Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization in Children and Adults (PALISADE)


Condition:   Peanut Allergy
Interventions:   Biological: AR101 powder provided in capsules & sachets;   Biological: Placebo powder provided in capsules & sachets
Sponsor:   Aimmune Therapeutics, Inc.
Active, not recruiting


Early Life Origins of the Food Allergy Epidemic


Condition:   Allergy to Peanut
Intervention:   Procedure: Double-blind placebo-controlled peanut challenge
Sponsor:   University of Manitoba
Enrolling by invitation


Oral Immunotherapy in Cow's Milk Allergy (CMA) in Children : "Petit Lait" Study


Condition:   Cow's Milk Allergy
Interventions:   Other: raw milk;   Other: Heated milk
Sponsor:   Dr Flore AMAT
Completed


Comparative Study of Specific IgE Levels to Common Foods and Aeroallergens Measured by EUROIMMUN Allergy and ImmunoCap


Condition:   Allergy
Interventions:   Other: EUROIMMUN Allergy;   Other: ImmunoCap
Sponsor:   Mahidol University
Completed


Formula for Children With Cow's Milk Allergy


Condition:   Milk Allergy
Interventions:   Other: Experimental Extensively Hydrolyzed Formula;   Other: Active Comparator Formula
Sponsor:   Perrigo Nutritionals
Completed


Integrated Approaches to Food Allergen and Allergy Risk Management


Condition:   Food Allergy
Intervention:   Other: food
Sponsors:   University of Zurich;   Cork University Hospital;   Charite University, Berlin, Germany;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   University of Nebraska Lincoln;   Region Hoverstaden;   Servicio Madrileño de Salud, Madrid, Spain;   Institut National de la Recherche Agronomique
Completed


Efficacy and Safety of Viaskin Milk in Children With IgE-Mediated Cow's Milk Allergy


Condition:   Food Allergy
Interventions:   Biological: Viaskin Milk 150 mcg;   Biological: Viaskin Milk 300 mcg;   Biological: Viaskin Milk 500 mcg;   Biological: Viaskin Placebo
Sponsor:   DBV Technologies
Active, not recruiting


Intranasal Diagnostics in Food Allergy: a Feasibility Study


Condition:   Food Allergy
Interventions:   Other: Intranasal challenge with active substance (food protein);   Other: Intranasal challenge with placebo
Sponsors:   Imperial College London;   National Institute for Health Research, United Kingdom
Enrolling by invitation


Boiled Peanut Oral Immunotherapy for the Treatment of Peanut Allergy: a Pilot Study


Condition:   IgE Mediated Peanut Allergy
Interventions:   Other: Desensitisation using boiled peanut;   Other: Desensitisation using boiled peanut (deferred start)
Sponsors:   Imperial College London;   University of Sydney;   National Institute for Health Research, United Kingdom
Active, not recruiting


Oral Immunotherapy for Wheat Allergy


Condition:   Wheat Allergy
Intervention:   Drug: Wheat OIT
Sponsor:   Hugh A Sampson, MD
Completed


Basophil Activation Test (BAT) Sensitivity in Child Food Allergy


Conditions:   Allergy to Egg;   Allergy to Peanut
Intervention:   Biological: Basophil Activation Test
Sponsor:   University Hospital, Rouen
Recruiting


The Safety and Efficacy of a Peanut Immunotherapy Dissolving Film for Peanut Allergy


Condition:   Peanut Allergy
Intervention:   Drug: Peanut Dissolving Film
Sponsors:   Johns Hopkins University;   Icahn School of Medicine at Mount Sinai
Suspended


The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults


Condition:   Food Allergy
Intervention:   Dietary Supplement: Dietary supplement
Sponsor:   Helsinki University Central Hospital
Active, not recruiting


OIT and Xolair® (Omalizumab) in Cow's Milk Allergy


Condition:   Milk Allergy
Interventions:   Biological: Placebo for omalizumab;   Biological: Omalizumab;   Drug: Milk powder
Sponsors:   Hugh A Sampson, MD;   National Institute of Allergy and Infectious Diseases (NIAID)
Completed


Trichuris Suis Ova in Peanut and Tree Nut Allergy


Condition:   Food Allergy
Intervention:   Drug: Trichuris suis ova (TSO)
Sponsors:   Beth Israel Deaconess Medical Center;   Food Allergy Initiative
Completed


Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study


Condition:   Wheat Allergy
Intervention:   Other: Commercial extract and in-house wheat extract
Sponsor:   Mahidol University
Completed


The Safety and Efficacy of Sublingual/Oral Immunotherapy for the Treatment of Milk Protein Allergy


Condition:   Milk Allergy
Interventions:   Drug: Milk Protein Extract Immunotherapy goal of 4mg/day;   Drug: Milk Protein Extract Immunotherapy goal of 7mg/day;   Drug: Milk Powder Immunotherapy goal dose 2000 mg/day;   Drug: Milk Powder Immunotherapy goal dose 1000mg/day
Sponsors:   Johns Hopkins University;   Duke University;   Greer Laboratories
Completed

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