High Blood Pressure

About High Blood Pressure Clinical Trials (Click to Open)

Join Clinical Trials for High Blood Pressure

High Blood PressureGeneral Purpose:

The term “blood pressure” refers to the amount of blood that your heart pumps and the amount of resistance it receives from your arteries. The higher your blood pressure, the more likely it is to cause health problems, including heart disease. 

Normal blood pressure is considered anything under 120/80 mm Hg, with 120 referring to the systolic pressure (the pressure in your arteries when your heart beats), and 80 referring to the diastolic pressure (the pressure in your arteries between heart beats).

A condition known as pre-hypertension is indicated by a blood pressure reading that falls between 120/80 and 139/89 mm Hg.

Mild (or stage 1) hypertension is characterized by a reading that ranges from 140/90 to 159/99 mm Hg.

Severe (stage 2) hypertension is any reading that measures 160/100 mm Hg or greater.

Typically, high blood pressure is diagnosed by taking two or three readings at two or more separate doctor’s office visits, in order to account for normal variations in blood pressure that occur throughout and between days.

One in every three adults in the United States has high blood pressure, and many more have it but are not aware that they do. Unfortunately, high blood pressure can exist for years before symptoms present themselves, which increases the risk of heart attack and stroke.

The good news is that high blood pressure can be diagnosed rather easily and there are a number of options available that can successfully help people lower and control their blood pressure.

In light of the high prevalence of high blood pressure, as well as its severe consequences if left untreated, considerable research is underway to develop more sensitive methods to detect body system damage due to high blood pressure, discover better ways to treat and control it, and gain an overall better understanding of how and why high blood pressure affects certain groups of individuals more often than others. 

What Will Clinical Trials for High Blood Pressure Be Like?

The types of tests and assessments used in clinical trials for high blood pressure will ultimately depend on the specific nature of the study and if other conditions, such as Clinical Trials for High Blood Pressurecertain types of cardiovascular disease, are also being studied. Provided below is a list of frequent procedures and tests used to evaluate the heart, lungs, and blood vessels, many of which may be incorporated for use in clinical trials for high blood pressure:

  • Physical exam
  • Blood pressure evaluation (using an inflatable blood pressure cuff and pressure gauge).
  • Detailed family history of heart diseases and cardiovascular disease.
  • Genetic testing
  • Blood tests to evaluate the effectiveness or chemical properties of a medication, if you are participating in a clinical trial that is investigating the use of a new drug.
  • If the study is evaluating aspects related to a particular type of heart disease, the following tests and procedures may also be utilized:
    • Cardiac catheterization: a procedure during which a long, thin, and flexible tube (i.e., catheter) is inserted into a blood vessel in the arm, upper thigh, or neck and threaded through until it reaches your heart. This allows doctors to perform diagnostic tests and treatments, as well as to evaluate blockages in the blood vessels.
    • Computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI) scans: these are non-invasive imaging procedures, similar to an x-ray, that allow doctors to take detailed pictures of your heart.
    • Coronary angiography: a procedure during which a dye is injected into a vein in your arm and then viewed using a special x-ray machine, CT scanner, or MRI machine.
    • Echocardiography (“echo”): a painless procedure that uses ultrasound to create moving pictures of your heart, which allow doctors to see its size, shape, and how well it is working.
    • Electrocardiogram (EKG, or ECG): a straightforward and painless procedure that records the electrical activity of the heart.
  • Stress test: a test performed while you exercise (usually by walking or running on a treadmill, or pedaling a stationary bicycle), which allows doctors to evaluate how your heart works during episodes of physical stress.
  • Pain and quality of life assessments, as well as diet, exercise and/or medication diaries, may also be required in some studies, depending on the research question being studied.

Typical High Blood Pressure Clinical Trial Protocol:

Specific examples of clinical trials for high blood pressure might include the following:Clinical Trials for High Blood Pressure

  • A randomized clinical trial to determine if patients with high blood pressure who use made-for-home blood pressure monitoring devices are more likely to take their blood pressure medications as prescribed than patients with high blood pressure who do not use such devices.
  • A clinical trial to determine if a specific combination of genetic mutations commonly found in individuals with coronary heart disease are present in a random sample of patients with high blood pressure but who have no evidence of other heart disease.
  • A randomized clinical trial to determine if standard treatment plus a newly developed drug is more effective at reducing and controlling stage 2 hypertension than standard treatment plus a placebo.
  • A long-term clinical trial to determine if lowering the systolic blood pressure of individuals with pre-hypertension, stage 1 or stage 2 hypertension is effective at preventing heart disease, as well as reducing the rate of memory loss and subsequent dementia due to increasing age and blood pressure.

A brief word about randomized trials and placebos:

Many clinical trials involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

Clinical Trials for High Blood PressureOn occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo (such as the third clinical trial example given above). Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value. 

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it. 

In rare instances where no standard therapy exists, or when a new drug or therapy is being investigated, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment. 

It is important to know that placebo-only trials are only conducted when scientifically necessary and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular disease or condition.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors. Therefore, it is important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you may want to have on hand include: 

  • Your specific diagnosis of high blood pressure (pre-hypertension, stage 1 or stage 2).
  • Your prior history of heart disease.
  • Your family history of heart disease.
  • Your prior history of treatment for high blood pressure and/or heart disease (including any surgeries, procedures, and medications).
  • Your current medications (including aspirin), vitamins, and dietary supplements.
  • Your most recent blood pressure, cholesterol, and triglyceride (i.e., lipid) levels.

Suggested Search Terms:

Once you are ready to begin your search for high blood pressure clinical trials, the following terms may be helpful when combined with either “high blood pressure” or “hypertension”:  “management,” “treatment,” “prevention,” “genetics,” “family history,” “pediatric,” “pulmonary,” “pregnancy,” “risk factors,” “obesity,” “diabetes,” and “heart disease.”

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“High Blood Pressure”

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Pragmatic Trial Comparing Telehealth Care and Optimized Clinic-Based Care for Uncontrolled High Blood Pressure


Condition:   Hypertension
Interventions:   Other: Best Practice Clinic-Based Care;   Other: Telehealth Care
Sponsors:   HealthPartners Institute;   Patient-Centered Outcomes Research Institute
Not yet recruiting - verified December 2016


A Multicenter Study to Evaluate the ROX Coupler in Subjects With Hypertension


Conditions:   Hypertension;   High Blood Pressure
Interventions:   Device: ROX Coupler;   Other: Sham procedure
Sponsor:   ROX Medical, Inc.
Recruiting - verified April 2017


Comparison of Optimal Hypertension Regimens


Condition:   Hypertension
Interventions:   Drug: Amlodipine;   Drug: Lisinopril;   Drug: Amiloride;   Drug: Chlortalidone
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   Medical Research Council
Not yet recruiting - verified July 2016


OPTImizing Precision of Hypertension Care to Maximize Blood Pressure Control Pilot (OPTI-BP Pilot)


Condition:   High Blood Pressure
Interventions:   Other: HTN PRA App;   Other: Blood Sample
Sponsors:   University of Florida;   OneFlorida Clinical Research Consortium
Active, not recruiting - verified February 2017


Spinal Cord Stimulation to Treat Hypertension


Condition:   Hypertension
Intervention:   Device: Precision Spectra System
Sponsor:   University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified April 2017


Primary Care Strategies to Reduce High Blood Pressure: A Cluster Randomized Trial in Rural Bangladesh, Pakistan and Sri Lanka


Condition:   Hypertension
Intervention:   Other: multi-component interventions
Sponsors:   Duke-NUS Graduate Medical School;   International Centre for Diarrhoeal Disease Research, Bangladesh;   Aga Khan University;   University of Kelaniya
Enrolling by invitation - verified March 2017


Community Study to Reduce High Blood Pressure Through Text Messaging (REACH OUT)


Conditions:   Hypertension;   Stroke
Intervention:   Behavioral: Text Messaging
Sponsor:   University of Michigan
Active, not recruiting - verified October 2016


Dietary Counseling to Reduce Salt Intake in Patients With High Blood Pressure


Condition:   Hypertension
Interventions:   Behavioral: Dietary Counseling;   Other: Control: Standard Care
Sponsors:   Ottawa Hospital Research Institute;   The Ottawa Hospital Academic Medical Association
Recruiting - verified July 2016


Evaluation of Quality of Care - Multi-disciplinary Risk Assessment and Management Programme for Patients With Hypertension, HA (QoC RAMP-HT)


Condition:   Hypertension
Intervention:  
Sponsors:   The University of Hong Kong;   Hospital Authority, Hong Kong
Active, not recruiting - verified October 2016


The Role of Gut Microbiota in Hypertension


Condition:   Hypertension
Intervention:   Other: Stool Sample and Blood Sample
Sponsor:   University of Florida
Recruiting - verified November 2016


Controlling Blood Pressure in Treatment Resistant Hypertension: A Pilot Study


Condition:   Hypertension
Interventions:   Drug: Renin treatment-guided Therapeutics;   Other: Referral Hypertension specialist;   Drug: Aldosterone Antagonist
Sponsors:   Medical University of South Carolina;   University of South Carolina
Completed - verified September 2014


Conditioned Pharmacotherapeutic Effects in Hypertension


Condition:   Hypertension
Intervention:   Drug: carvedilol
Sponsor:   University of Rochester
Recruiting - verified May 2017


Optimizing Linkage and Retention to Hypertension Care in Rural Kenya


Conditions:   Hypertension;   High Blood Pressure
Interventions:   Behavioral: behavioral communication strategy;   Behavioral: Behavioral communication strategy, plus smartphone-based tool
Sponsors:   Icahn School of Medicine at Mount Sinai;   Moi University
Recruiting - verified December 2016


A Multicenter Study to Evaluate the ROX Arteriovenous Coupler in Patients With Treatment-Resistant Hypertension


Condition:   Hypertension
Intervention:   Device: ROX COUPLER
Sponsor:   ROX Medical, Inc.
Active, not recruiting - verified September 2016


Barostim Neo System in the Treatment of Resistant Hypertension


Condition:   High Blood Pressure
Intervention:   Device: Barostim Neo System
Sponsor:   CVRx, Inc.
Active, not recruiting - verified October 2016


A Study of Safety and Efficacy in MK-0954A Combination in Participants With Hypertension (MK-0954A-373 AM3)


Condition:   Hypertension
Intervention:   Drug: Losartan 50 mg / HCTZ 12.5 mg
Sponsor:   Merck Sharp & Dohme Corp.
Completed - verified March 2017


The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension


Condition:   High Blood Pressure
Interventions:   Drug: Nebivolol;   Drug: Metoprolol XL
Sponsors:   Emory University;   Forest Laboratories
Completed - verified March 2017


Trial Using Motivational Interviewing Positive Affect and Self-Affirmation in Hypertension (TRIUMPH)


Condition:   Hypertension
Interventions:   Behavioral: Positive Affect/Self-Affirmation/Motivational Interviewing;   Behavioral: Educational and Behavioral
Sponsors:   Weill Medical College of Cornell University;   National Institute on Minority Health and Health Disparities (NIMHD)
Completed - verified February 2017


Chiropractic for Hypertension in Patients


Condition:   Hypertension
Interventions:   Other: Spinal Manipulation;   Other: Sham Spinal Manipulation
Sponsor:   Palmer College of Chiropractic
Completed - verified September 2016


Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition Study


Condition:   Hypertension
Intervention:   Drug: Lisinopril, Atenolol
Sponsors:   Brigham and Women's Hospital;   University of Utah
Active, not recruiting - verified May 2017


A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Patients With Essential Hypertension


Condition:   Essential Hypertension
Intervention:   Drug: aliskiren /amlodipine/hydrochlorothiazide
Sponsor:   Novartis
Completed - verified November 2012


Analysis of Genes That Predispose People to Develop High Blood Pressure


Condition:   Hypertension
Intervention:  
Sponsors:   University of Maryland;   National Heart, Lung, and Blood Institute (NHLBI)
Completed - verified March 2017


Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)


Condition:   Hypertension
Intervention:   Drug: Valsartan + Amlodipine besilate
Sponsor:   Novartis
Completed - verified March 2017



A Clinical Study to Assess Efficacy and Safety of Aliskiren in the Elderly With High Blood Pressure


Condition:   Hypertension
Intervention:   Drug: aliskiren
Sponsor:   Novartis
Completed - verified November 2016

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