Heart Attack

About Heart Attack Clinical Trials (Click to Open)

Join Clinical Trials for Heart Attacks

clinical trials for heart attacksGeneral Purpose:  

Heart attacks, also known as myocardial infarction, are all too common in the United States. They affect both men and women, and although they have a number of well-known risk factors, they can also strike even the healthiest of individuals. They usually occur when a blood clot blocks the flow of blood through the coronary arteries into the heart.

Although they can be sudden and fatal, heart attacks can also produce symptoms that many people confuse with minor illnesses, which often delays their seeking help and decreases the likelihood of complete recovery. Fortunately, however, adopting healthy lifestyle choices with regard to diet, exercise, and stress management can not only improve recovery efforts following heart attacks, but help to prevent them altogether.

 As a result of their frequent occurrence, time-sensitive treatment needs, and the possibility of prevention, tremendous research is devoted to discovering better methods of diagnosing and treating heart attacks, helping high-risk individuals modify their risk factors, and rehabilitating the body, mind, and spirit of those who have survived them.

What Will Clinical Trials for Heart Attacks Be Like? 

The types of tests and assessments used in heart attack clinical trials will ultimately depend on the specific nature of the study and what aspects of heart attack are being clinical trials for heart attacksinvestigated. Provided below is a list of frequent procedures and tests used to evaluate the heart, heart functioning, and its impact on the body in general, many of which may be incorporated for use in clinical trials for heart attacks:

  • Physical exam
  • Electrocardiogram (EKG, or ECG): Often the first test done to diagnose a heart attack, EKG is a straightforward and painless procedure that records the electrical activity of the heart. This test tells doctors how fast your heart is beating, the regularity (or irregularity) of your heart rhythm, and strength and timing of the electrical signals that constantly pass through the heart.
  • Blood tests to identify specific enzymes that are leaked into the blood stream by damaged heart muscle following a heart attack are also performed.
  • Chest x-ray
  • Echocardiography (“echo”): a painless procedure that uses ultrasound to create moving pictures of your heart, which allow doctors to see its size, shape, and how well it is working. During a procedure known as transesophageal echocardiography, a long, thin ultrasound probe is guided down the throat into the esophagus, which is directly behind the heart, in order to obtain more detailed pictures.
  • Cardiac catheterization: a procedure during which a long, thin, and flexible tube (i.e., catheter) is inserted into a blood vessel in the arm, upper thigh, or neck and threaded through until it reaches your heart. This allows doctors to perform diagnostic tests and treatments, as well as to evaluate blockages in the blood vessels.
  • Coronary angiography: a procedure during which a dye is injected into a vein in your arm and then viewed using a special x-ray machine, CT scanner, or MRI machine. This allows doctors to view the insides of the arteries that provide blood to your heart. Angiography may also be used to evaluate other blood vessels throughout the body.
  • Stress test: a test performed while you exercise (usually by walking or running on a treadmill, or pedaling a stationary bicycle), which allows doctors to evaluate how your heart works during episodes of physical stress.
  • Computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI) scans: these are non-invasive imaging procedures, similar to an x-ray, that allow doctors to take detailed pictures of your heart.
  • Blood tests to evaluate the effectiveness or chemical properties of a medication, if you are participating in a clinical trial that is investigating the use of a new drug.
  • Pain and quality of life assessments, as well as exercise diaries, may also be required in some studies, depending on the research question being studied.

Typical Protocol for Clinical Trials for Heart Attacks: 

clinical trials for heart attacksSpecific examples of Clinical Trials for Heart Attacks might include the following:

  • A long-term study conducted among women ages 18 to 55 with a recent history of heart attack, during which genetic, lifestyle/behavioral, and clinical information is collected to determine which factors are associated with a a poor recovery following a heart attack.
  • A randomized clinical trial to determine if a new drug designed to treat heart damage immediately following a heart attack is safe and effective when administered to heart attack patients already undergoing standard treatment via cardiac catheterization. In a trial such as this, these patients would be compared to a similar group of patients receiving treatment via cardiac catheterization; however the comparison group would receive a placebo rather than the investigational drug (see text below regarding randomized trials and placebos).
  • A study to determine if a cardiac rehabilitation program for heart attack survivors has a greater impact on improving depressive symptoms than standard psychotherapy for depression.
  • A study in which heart attack survivors and any of their first- and second-degree relatives who also have a history of heart attack provide blood and tissue samples for the purposes of genetic analysis.

A brief word about randomized trials and placebos: 

Many clinical trials, to include clinical trials for heart attacks, involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo (such as the second clinical trial example given above). Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical clinical trials for heart attackstrial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug or therapy is being investigated, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

It is important to know that placebo-only trials are only conducted when scientifically necessary and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular disease or condition. 

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, including your history of heart disease, treatment history, and a variety of clinical findings. Therefore, it is important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you may want to have on hand include:

  • Your prior history of heart disease
  • Your prior history of treatment for heart disease (including any surgeries, procedures, and medications)
  • Your current medications (including aspirin), vitamins, and dietary supplements
  • Your most recent blood pressure, cholesterol, and triglyceride (i.e., lipid) levels 

Suggested Search Terms:

Once you are ready to begin your search for clinical trials, the following terms may be of use (note: you will likely obtain similar search results whether you use ‘myocardial infarction’ or ‘heart attack’ as the main search term): “heart attack rehabilitation,” “heart attack risk factors,” “heart attack prevention,” “heart attack treatment,” “heart attack symptoms,” “heart attack exercise,” “heart attack diabetes,” “heart attack high blood pressure,” “heart attack youth,” “clinical trials for heart attacks,” “heart attack quality of life,” and “heart attack depression.”

Current Search Term:

“Heart Attack”

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Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction

Condition:   Myocardial Infarction, Acute
Interventions:   Device: Remote ischemic conditioning and intracoronary ischemic conditioning;   Device: Patients with no remote ischemic conditioning and no intracoronary ischemic conditioning
Sponsor:   Hospices Civils de Lyon
Not yet recruiting - verified May 2017

Dextran Use for Primary Angioplasty Protection in Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction With ST Elevation
Intervention:   Procedure: Controlled Reperfusion
Sponsor:   Centro Cardiovascular Salta
Not yet recruiting - verified May 2017

Women's Heart Attack Research Program: Platelet Sub-Study (HARP)

Condition:   Myocardial Infarction
Sponsor:   New York University School of Medicine
Recruiting - verified January 2017

Mechanistic Effects of Colchicine in Patients With Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Drug: Colchicine 0.6 mg tablets
Sponsor:   New York University School of Medicine
Recruiting - verified May 2017

CARdioprotection in Myocardial Infarction

Condition:   Myocardial Infarct
Intervention:   Other: Imagery
Sponsor:   EZUS-LYON 1
Recruiting - verified November 2016

Women's Heart Attack Research Program: Stress Ancillary Study

Condition:   Myocardial Infarction
Interventions:   Behavioral: Enhanced Usual Care;   Behavioral: Stress Management;   Device: Actigraph
Sponsor:   New York University School of Medicine
Recruiting - verified January 2017

Women's Heart Attack Research Program- Imaging Study

Condition:   Myocardial Infarction
Interventions:   Device: OCT;   Other: CMR
Sponsor:   New York University School of Medicine
Recruiting - verified January 2017

Bivalirudin in Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Drug: Bivalirudin;   Drug: heparin
Sponsor:   Shenzhen Salubris Pharmaceuticals Co., Ltd.
Recruiting - verified November 2016

Ad-HGF Treatment for Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Ad-HGF;   Other: 0.9% NaCl
Sponsor:   The First Affiliated Hospital with Nanjing Medical University
Not yet recruiting - verified June 2016

Inflammatory Response in Myocardial Infarction Evaluated by MRI and Biomarkers

Condition:   Myocardial Infarction
Interventions:   Other: MRI at D7;   Biological: Blood samples
Sponsor:   Hospices Civils de Lyon
Not yet recruiting - verified July 2016

Baduanjin Exercise Prevents Post-Myocardial Infarction Left Ventricular Remodeling (BE-PREMIER Trial)

Condition:   Myocardial Infarction
Interventions:   Other: Baduanjin exercise;   Other: aerobic exercise
Sponsor:   Guangdong Provincial Hospital of Traditional Chinese Medicine
Not yet recruiting - verified August 2016

P3AMI Antiplatelet Trial

Condition:   Heart Attack
Interventions:   Drug: Prasugrel;   Drug: Clopidogrel;   Drug: ticagrelor
Sponsor:   The Royal Wolverhampton Hospitals NHS Trust
Recruiting - verified April 2016

China PEACE II: Quality Improvement for Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Interventions:   Behavioral: Quality improvement strategies and tools;   Behavioral: Process optimization
Sponsor:   China National Center for Cardiovascular Diseases
Completed - verified October 2016

Sequential Therapy of Atorvastatin Improve Outcomes of ST-elevated Acute Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Drug: Sequential therapy of atorvastatin
Sponsor:   Zhang Qi, MD
Active, not recruiting - verified October 2016

SILVER-AMI: Outcomes in Older Persons With Heart Attacks

Condition:   Acute Myocardial Infarction
Sponsors:   Sarwat Chaudhry;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting - verified January 2017

REsistance to Aspirin and Clopidogrel in acuTe Myocardial Infarction

Condition:   Acute Myocardial Infarction
Intervention:   Drug: Aspirin 200mg qd, Clopidogrel 2x75mg qd
Sponsor:   University Hospital Ostrava
Completed - verified October 2016

Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.

Condition:   Myocardial Infarction
Intervention:   Drug: Injectable (i.v.) metoprolol tartrate (up to 15 mg).
Sponsors:   Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III;   Ministerio de Sanidad, Servicios Sociales e Igualdad;   Fundación Mutua Madrileña
Active, not recruiting - verified February 2017

Efficacy and Safety of Adjunctive Cilostazol in Acute Myocardial Infarction Patients

Condition:   Acute Myocardial Infarction
Intervention:   Drug: antiplatelet therapy
Sponsor:   Korea University Guro Hospital
Recruiting - verified April 2017

Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Drug: Eplerenone;   Drug: Placebo
Sponsor:   Pfizer
Completed - verified July 2016

Autologous Bone Marrow Derived Stem Cells for Acute Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Biological: MNC;   Biological: AC 133;   Biological: Control
Sponsor:   Royan Institute
Completed - verified July 2010

Relation Between Aldosterone and Cardiac Remodeling After Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Biological: blood sample;   Procedure: MRI;   Procedure: echocardiography;   Biological: urine sample;   Procedure: pulmonary echography;   Procedure: vascular check;   Procedure: renal echography
Sponsor:   Central Hospital, Nancy, France
Active, not recruiting - verified May 2017

Postconditioning in ST-elevation Myocardial Infarction

Condition:   Myocardial Infarction
Interventions:   Procedure: Postconditioning;   Procedure: Control intervention
Sponsor:   Oslo University Hospital
Completed - verified September 2016

Can Hypothermia be Incorporated Into Primary Angioplasty for Heart Attack?

Condition:   ST-Elevation Myocardial Infarction
Intervention:   Device: Life Recovery Systems ThermoSuit
Sponsor:   Life Recovery Systems
Not yet recruiting - verified August 2016

The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty

Condition:   Acute Myocardial Infarction
Intervention:   Drug: melatonin
Sponsor:   Alberto Domínguez Rodríguez
Terminated - verified July 2016

Which Therapy for Acute Heart Attacks? (The WEST Study)

Condition:   Myocardial Infarction
Interventions:   Drug: tenecteplase;   Drug: enoxaparin;   Drug: clopidogrel;   Procedure: percutaneous coronary intervention
Sponsors:   University of Alberta;   Hoffmann-La Roche;   Sanofi;   Eli Lilly and Company
Completed - verified July 2005

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