Lung Cancer

About Lung Cancer Clinical Trials (Click to Open)

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General Purpose:

Lung Cancer Clinical TrialsLung cancer is unfortunately all too common in the United States, and is the most common cause of cancer-related death among both men and women. In fact, over 160,000 people in the United States will die as a result of lung cancer in 2012. Which means, there are a lot of different lung cancer clinical trials ongoing.

Due to its widespread prevalence and associated mortality, researchers are hard at work investigating newer and better ways to prevent and treat lung cancer, as well as to improve diagnostic capabilities and find more accurate ways to screen for it.

What Will Lung Cancer Clinical Trials Be Like?

Lung cancer clinical trials may involve many common tests and procedures; however, the ultimate design of the particular study will determine which specific procedures you will undergo. Examples of specific tests and procedures that may be used in a clinical trial for lung cancer include the following:

  • Physical exam
  • Blood and/or tissue sample for the purposes of conducting genetic testing.
  • If the study is evaluating a new type of medication or vaccine, blood and/or urine tests may be performed to monitor how your body metabolizes the medication or how effectively your body has responded to the vaccine.Lung Cancer Clinical Trials
  • Sputum sample (mucus coughed up from the lungs) for analysis.
  • Thoracentisis, which is a procedure that uses a long needle to remove fluid from the chest in order to examine it for the presence of cancer cells.
  • Bronchoscopy, which involves inserting a thin, lighted tube with a tiny camera attached through the nose or mouth into the tube in order to take pictures inside the lungs and airways.
  • Chest x-rays
  • Biopsy
  • Surgery
  • Radiation therapy
  • Quality of life assessments to evaluate how your cancer is impacting your ability to perform activities of daily living.
  • Pain assessments
  • Dietary assessments

Typical Protocol for Lung Cancer Clinical Trials:

Research related to lung cancer and lung cancer clinical trials are ongoing and currently investigating a number of aspects related to its prevention, diagnosis, and treatment. Sample clinical trials might include the following:

  • A clinical trial to compare the effectiveness of two different smoking cessation programs offered to lung cancer patients who continue to smoke following their diagnosis.
  • A study designed to evaluate if a new diagnostic test that can recognize specific DNA changes in cells collected from sputum samples can help detect lung cancers at an earlier stage.
  • A clinical trial that compares standard chemotherapy for lung cancer to a combination of standard therapy plus a new drug to see which treatment is most effective at reducing the size of the tumor.
  • A study in which lung cancer patients provide a sample of their tumor to be tested for specific proteins that can indicate how the tumor will respond to certain types of chemotherapy.
  • A clinical trial that compares standard chemotherapy for lung cancer to a combination of standard chemotherapy plus a vaccine designed to prompt the body’s immune system to attack and kill vital portions of lung cancer cells.

A brief word about randomized trials and placebos:

Many clinical trials involve the comparison of an investigational treatment to a “standard” Lung Cancer Clinical Trialstreatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

This is rarely done in cancer clinical trials; however it may occasionally be necessary from a scientific standpoint. Placebo-only trials will only be done when ethically appropriate and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular type of cancer and clinical situation.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, including your disease stage, treatment history, and a variety of clinical findings. Therefore, it is Lung Cancer Clinical Trialsimportant to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you will want to have on hand include:

  • The name, location, size, stage, and cell type of your cancer (i.e. small cell lung cancer or non-small cell lung cancer), as well as the locations of any metastases you have. Also know these details for any prior cancer you have had.
  • Know your performance status, which estimates how well you perform normal activities of daily living. Examples: Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know your treatment history, including chemotherapy, radiation therapy, immunotherapy, and/or surgery.
  • Know your blood cell counts, liver function test results, and kidney function test results.

Suggested Search Terms:

Once you are ready to begin your search for lung cancer clinical trials, the following search terms may be of use when combined with the specific type of lung cancer you have:

“lung cancer treatment,” “radiation therapy,” “chemotherapy,” “surgery,” “diet,” “nutrition,” “vaccine,” “screening,” and “smoking.”

Current Search Term:

“Lung Cancer”

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AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: Carboplatin;   Drug: Paclitaxel;   Drug: AZD1775
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
Recruiting - verified May 2017


A Study to Optimize Care for Lung Cancer Patients Undergoing Video-Assisted Thoracoscopic Surgery (VATS)


Condition:   Lung Cancer
Intervention:   Other: VATS-associated best practices
Sponsors:   Dana-Farber Cancer Institute;   Ethicon Endo-Surgery
Recruiting - verified February 2017


Pilot Study of Novel Fluorescence Endoscopic Device for Sentinel Lymph Node Mapping in Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: Indocyanine green (ICG);   Device: FluoSCOPE
Sponsors:   Dana-Farber Cancer Institute;   Beth Israel Deaconess Medical Center;   Akorn, Inc.
Recruiting - verified August 2016


Rapid Learning for Lung Cancer


Condition:   Lung Cancer
Intervention:  
Sponsors:   Maastricht Radiation Oncology;   Liverpool Cancer Therapy Centre;   Macarthur Cancer Therapy Centre, Liverpool;   Ingham Institute Hospital, Liverpool;   NSW, Australia
Completed - verified September 2016


Stereotactic Body Radiation for Consolidation After Standard Chemoradiation for Stage 3 Lung Cancer


Condition:   Lung Cancer
Interventions:   Radiation: Stereotactic radiation Arm 1;   Radiation: Stereotactic radiation Arm 2;   Radiation: Stereotactic radiation Arm 3;   Radiation: Stereotactic radiation Arm 4
Sponsors:   Dr Thomas DiPetrillo;   Memorial Hospital of Rhode Island
Active, not recruiting - verified July 2016


Lung Cancer Diagnosis and Staging Using Ultrasound Guidance


Condition:   Lung Cancer
Intervention:  
Sponsor:   Singapore General Hospital
Completed - verified February 2017


A Feasibility Study Using Four-Dimensional CT Imaging for Primary Lung Cancer


Condition:   Lung Cancer
Intervention:   Radiation: 4D-CT pre-treatment scan
Sponsors:   James Graham Brown Cancer Center;   University of Louisville
Recruiting - verified November 2016


Lung Cancer Exercise Training Study


Condition:   Lung Cancer
Interventions:   Behavioral: Exercise Training;   Behavioral: Progressive Stretching
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI);   Duke University
Recruiting - verified April 2017


Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Radiation: Prophylactic Cranial Irradiation;   Radiation: Radiation Therapy
Sponsors:   Radiation Therapy Oncology Group;   National Cancer Institute (NCI);   NRG Oncology
Completed - verified December 2016


Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer


Condition:   Lung Cancer
Interventions:   Genetic: comparative genomic hybridization;   Genetic: gene expression microarray analysis;   Genetic: proteomic profiling analysis;   Other: biologic sample preservation procedure;   Procedure: nasal brushing;   Procedure: Blood draw;   Procedure: Urine collection;   Procedure: sputum sample;   Procedure: fluorescence bronchoscopy with airway biopsy;   Procedure: fine needle aspiration of the lung;   Procedure: thoracentesis
Sponsors:   Vanderbilt-Ingram Cancer Center;   National Cancer Institute (NCI)
Recruiting - verified July 2016


Protein and RNA Expression Patterns in Predicting Response to Treatment in Patients With Lung Cancer


Condition:   Lung Cancer
Interventions:   Genetic: DNA/RNA sequencing and expression levels;   Genetic: Protein expression analysis;   Procedure: Lung tumor biopsy;   Procedure: Blood sample
Sponsors:   Vanderbilt-Ingram Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified March 2017


Studying Tumor Tissue Samples and Blood Samples to Learn More About DNA Changes in Patients With Lung Cancer


Condition:   Lung Cancer
Intervention:  
Sponsor:   University of California, Davis
Recruiting - verified January 2017


Radiation Therapy Regimens in Treating Patients With Limited-Stage Small Cell Lung Cancer Receiving Cisplatin and Etoposide


Condition:   Lung Cancer
Interventions:   Radiation: Standard Radiation Dose Therapy;   Drug: cisplatin;   Drug: etoposide;   Radiation: High Radiation Dose Therapy;   Drug: carboplatin
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Recruiting - verified April 2017


Quality of Life in Lung Cancer Survivors


Condition:   Lung Cancer Survivors
Intervention:   Behavioral: questionnaires or telephone interview
Sponsors:   Memorial Sloan Kettering Cancer Center;   Fox Chase Cancer Center
Active, not recruiting - verified July 2016


Lung Cancer Biomarkers and Screening


Condition:   Lung Cancer
Intervention:  
Sponsor:   New York University School of Medicine
Recruiting - verified October 2016


Pemetrexed Disodium and Carboplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: carboplatin;   Drug: pemetrexed disodium;   Radiation: radiation
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016


ZD6474 in Treating Patients With Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: vandetanib;   Procedure: adjuvant therapy
Sponsor:   Genzyme, a Sanofi Company
Completed - verified August 2016


Combination Chemotherapy and Exisulind in Treating Patients With Extensive-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: carboplatin;   Drug: etoposide;   Drug: exisulind
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified December 2016


Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Biological: filgrastim;   Drug: carboplatin;   Drug: etoposide;   Drug: paclitaxel;   Drug: topotecan hydrochloride;   Radiation: radiation therapy
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016


Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: carboplatin;   Drug: etoposide;   Drug: topotecan hydrochloride;   Radiation: radiation therapy
Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
Completed - verified August 2009


Combination Chemotherapy in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: gemcitabine hydrochloride;   Drug: irinotecan hydrochloride
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016


Paclitaxel in Treating Patients With Extensive-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Intervention:   Drug: paclitaxel
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016


Topotecan and Paclitaxel in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Drug: paclitaxel;   Drug: topotecan hydrochloride;   Radiation: radiation therapy
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016


Lepirudin in Treating Patients With Recurrent or Advanced Small Cell Lung Cancer


Condition:   Lung Cancer
Intervention:   Biological: lepirudin
Sponsors:   Dartmouth-Hitchcock Medical Center;   National Cancer Institute (NCI)
Terminated - verified June 2016


Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer


Condition:   Lung Cancer
Interventions:   Biological: filgrastim;   Drug: carboplatin;   Drug: etoposide;   Drug: paclitaxel;   Drug: topotecan hydrochloride;   Radiation: radiation therapy
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016

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