Stomach (Gastric) Cancer

About Stomach (Gastric) Cancer Clinical Trials (Click to Open)

Join Clinical Trials for Stomach Cancer 

Clinical Trials for Stomach Cancer General Purpose:

Stomach cancer affects just over 20,000 individuals in the United States each year, most of whom are over the age of 70. Little is known about what exactly causes stomach cancer to develop, however a number of risk factors have been identified, including infection with a bacterium known as Helicobacter pylori or (H. pylori), smoking, family history, poor diet, sedentary lifestyle, and obesity. So, clinical trials for stomach cancer tends to seek elderly volunteers more so than younger ones.

Nevertheless, many individuals who are diagnosed with stomach cancer have no known risk factors. There are several types of stomach cancer, the most common of which is adenocarcinoma.

Other types include lymphoma, carcinoid cancer, and gastrointestinal stromal tumors (or GIST), however all of these types of stomach cancer are relatively rare compared to adenocarcinoma.

Fortunately, research related to stomach cancer is ongoing and researchers are working hard to identify the causes of it, as well as ways to prevent its development and treat it more effectively.

In addition to the ongoing clinical trials for stomach cancer, rates of stomach cancer are declining every year in the United States, which is encouraging news for both those with stomach cancer, and those who have known risk factors for its development.

What Will Clinical Trials for Stomach Cancer Be Like?

When participating in a stomach cancer clinical trial, there are a few basic tests and procedures you may receive; however, the ultimate design of the particular study will determine which specific procedures you will undergo. Some of the following tests and procedures may be used during stomach cancer clinical trials:

  • Physical exam
  • Endoscopy, a procedure during which a thin, flexible tube with a tiny light and camera at the end is passed down the throat and into the stomach.
  • Biopsy
  • Computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI) scans. These imaging procedures are non-invasive and provide detailed pictures of areas inside your body.
  • Positron emission tomography (PET) scan, which is an imaging procedure that uses a radioactive sugar injected into the blood through a vein in the arm. This substance attaches to cancer cells in the body, making them visible when viewed by a special camera.
  • Surgery, either to treat the cancer or for exploratory purposes to determine how far the cancer has spread from the stomach.
  • If the study is evaluating a new type of medication or vaccine, blood and/or urine tests may be performed to monitor how your body metabolizes the medication or how effectively your body has responded to the vaccine.
  • Quality of life assessments to evaluate how your cancer is impacting your ability to perform activities of daily living.
  • Pain assessments

Typical Protocol for Clinical Trials for Stomach Cancer:

Despite its low prevalence, researchers continue to work hard to investigate numerous aspects of stomach cancer, including its causes, as well as ways to improve treatment. Clinical Trials for Stomach Cancer Sample clinical trials might include the following:

  • A clinical trial that investigates whether individuals who are infected with H. pylori and who smoke are more likely to develop stomach cancer later in life than those who are infected with the bacterium but who do not smoke.
  • A long-term clinical trial that investigates whether individuals at high risk of developing stomach cancer have a lower risk after long-term use of a nutritional supplement containing vitamin E, vitamin C, vitamin A, and selenium.
  • A study designed to determine if the long-term treatment of H. pylori infection with regular antibiotic therapy lowers an individual’s risk of developing stomach cancer.
  • A clinical trial to compare the use of a minimally-invasive surgical technique with standard surgical treatment for stomach cancer to determine if the new technique a) has fewer side effects and b) results in a more complete removal of the tumor.
  • A clinical trial to determine if using chemotherapy before standard surgical removal of stomach cancer is more effective in preventing recurrence of the cancer than standard surgery alone (i.e., without chemotherapy).
  • A clinical trial to determine if standard chemotherapy plus a targeted therapy that attacks specific proteins within cancer cells is more effective at treating stomach cancer than standard chemotherapy alone.

A brief word about randomized trials and placebos:

Many clinical trials involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

Clinical Trials for Stomach Cancer On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

This is rarely done in cancer clinical trials; however it may occasionally be necessary from a scientific standpoint. Placebo-only trials will only be done when ethically appropriate and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular type of cancer and clinical situation.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, including your disease stage, treatment history, and a variety of clinical findings. Therefore, it is Clinical Trials for Stomach Cancer important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you will want to have on hand include:

  • The name, location, size, stage, and cell type of your cancer, as well as the locations of any metastases you have. Also know these details for any prior cancer you have had.
  • Know your performance status, which estimates how well you perform normal activities of daily living. Examples: Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know your treatment history, including chemotherapy, radiation therapy, immunotherapy, and/or surgery.
  • Know your blood cell counts, liver function test results, and kidney function test results.

Suggested Search Terms for Clinical Trials for Stomach Cancer:

Once you are ready to begin your search for stomach cancer clinical trials, it might be best to use the specific type of stomach cancer you have (e.g., adenocarcinoma or gastrointestinal stromal tumor [or even “GIST”]), followed by any one of the terms listed below. However, if that approach results in too few findings, try using “stomach cancer” rather than your stomach cancer type.

The following search terms may be of use when combined with either your specific stomach cancer  type or the term:

“stomach cancer”: “treatment,” “chemotherapy,” “radiation therapy,” “management,” “surgery,” “advanced,” “immune therapy,” “helicobacter pylori,” “diet,” “screening,” “risk factors,” and “side effects,” “Clinical Trials for Stomach Cancer.”

Current Search Term:

Gastric Cancer

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Molecular Evaluation of Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer

Condition:   Gastric Cancer
Sponsor:   Beijing Cancer Hospital

Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

Condition:   Gastric Cancer
Intervention:   Dietary Supplement: cereal or grain consumption
Sponsor:   West China Hospital

Compare Chemotherapy of XELOX for 4 Months to 6 Months After D2 Gastrectomy for Gastric Cancer Staged II or III.

Condition:   Gastric Cancer
Interventions:   Drug: Oxaliplatin;   Drug: Capecitabine
Sponsor:   Sun Yat-sen University

Chemotherapy Alone Versus Surgery Plus Chemotherapy for Distal Gastric Cancer With One Non-curable Factor

Condition:   Gastric Cancer
Interventions:   Procedure: surgery;   Drug: chemotherapy
Sponsor:   Sun Yat-sen University

Peritoneal Lavage for Early Detecting Gene Mutation of Peritoneal Metastasis of Gastric Cancer

Condition:   Gastric Cancer
Intervention:   Other: Observational study
Sponsor:   Sun Yat-sen University

Robotic Versus Laparoscopic Distal Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Procedure: Robotic distal gastrectomy with D2 nodal dissection;   Procedure: Laparoscopic distal gastrectomy with D2 nodal dissection
Sponsors:   Southwest Hospital, China;   Chinese PLA General Hospital;   West China Hospital;   Xijing Hospital of Digestive Diseases;   Nanjing PLA General Hospital;   Beijing Cancer Hospital;   Qingdao University;   Fujian Medical University Union Hospital;   Central South University;   The First Affiliated Hospital of Nanchang University;   Sun Yat-sen University;   Wuhan Union Hospital, China;   Jilin Provincial Tumor Hospital;   Lanzhou General Hospital of PLA
Not yet recruiting

Clinical Study on Treatment of Apatinib Mesylate in First-line Maintenance of Advanced Gastric Cancer

Condition:   Advanced Gastric Cancer
Intervention:   Drug: apatinib
Sponsor:   DongMa
Enrolling by invitation

Neoadjuvant Chemotherapy for Patients With Advanced Gastric Cancer in ERAS Programs for Radical Gastrectomy

Condition:   Gastric Cancer
Interventions:   Procedure: NAC group;   Procedure: Surgery alone group
Sponsor:   JIANG Zhi-Wei

Multimodal Analgesia in Laparoscopic Radical Gastrectomy With Gastric Cancer: a Multi-center Study

Condition:   Gastric Cancer
Interventions:   Procedure: Multimodal analgesia;   Procedure: PCIA analgesia
Sponsors:   JIANG Zhi-Wei;   Pfizer

The Clinical Research of Mesylate Apatinib Combined With Docetaxel and S-1 as the First-line Treatment of Metastatic Gastric Cancer

Condition:   Metastatic Gastric Cancer
Intervention:   Drug: docetaxel
Sponsors:   Zhou Fuxiang;   Hubei Cancer Hospital;   Huangshi Central Hospital;   The Central Hospital of Huanggang;   Xianning Central Hospital;   Shiyan Taihe Hospital;   The first hospital of Zaoyang;   Hanchuan City people's Hospital;   Yangxin People's Hospital;   Tianmen People's Hospital

Enhanced Recovery After Surgery Program for Gastric Cancer: a Multi-center Study

Condition:   Gastric Cancer
Intervention:   Procedure: enhanced recovery after surgery
Sponsor:   Jinling Hospital, China

The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer

Condition:   Gastric Cancer
Intervention:   Drug: dexmedetomidine
Sponsor:   Nanjing PLA General Hospital
Not yet recruiting

Apatinib for the Elderly Advanced Gastric Cancer

Condition:   Gastric Cancer
Intervention:   Drug: Apatinib
Sponsor:   Affiliated Hospital of Qinghai University

The Study of Conversion Surgery for Apatinib in Combination With SOX for Patients With Unresectable Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Drug: Apatinib;   Drug: Oxaliplatin;   Drug: S-1
Sponsor:   Chinese PLA General Hospital

Multicentric Randomised Trial for Resectable Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Drug: Docetaxel;   Drug: Oxaliplatin;   Drug: Capecitabine;   Procedure: gastrectomy;   Radiation: radiotherapy of gastric cancer;   Drug: Paclitaxel;   Drug: Carboplatin
Sponsor:   The Netherlands Cancer Institute

Adjuvant Chemotherapy With S-1 Plus Oxaliplatin Versus S-1 Alone in Locally Advanced Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Drug: Oxaliplatin plus S-1;   Drug: S-1 only
Sponsor:   Beijing Cancer Hospital

Extensive Intraoperative Peritoneal Lavage After Curative Gastrectomy for Locally Advanced Gastric Cancer (EIPL)

Condition:   Gastric Cancer
Intervention:   Other: Extensive Intraoperative Peritoneal Lavage
Sponsors:   Sun Yat-sen University;   Anhui Provincial Hospital;   The First Affiliated Hospital of Anhui Medical University;   Anqing Municipal Hospital;   Yuebei People's Hospital;   The First Affiliated Hospital of Guangdong Pharmaceutical University;   Guangdong Provincial Hospital of Traditional Chinese Medicine;   Jiangsu Cancer Institute & Hospital;   Jiangxi Provincial Cancer Hospital;   Tianjin Medical University Cancer Institute and Hospital;   First Affiliated Hospital of Wannan Medical College;   Lishui hospital of Zhejiang University;   Second Affiliated Hospital, School of Medicine, Zhejiang University

Three Drugs in Advanced Gastric Cancer Neoadjuvant Chemotherapy for Stage Ⅲ Clinical Study

Condition:   Gastric Cancer
Interventions:   Drug: docetaxel,0xaliplatin,capecitabine;   Drug: oxaliplatin,capecitabine
Sponsors:   Qun Zhao;   Jiangsu HengRui Medicine Co., Ltd.

Study of TAS-102 or Placebo Plus BSC in Patients With Metastatic Gastric Cancer

Condition:   Refractory Metastatic Gastric Cancer
Interventions:   Drug: TAS-102;   Drug: Placebo
Sponsor:   Taiho Oncology, Inc.
Active, not recruiting

A Comparison of Laparoscopic With Open Distal Gastrectomy in Advanced Gastric Cancer After Neoadjuvant Chemotherapy

Condition:   Gastric Cancer
Interventions:   Drug: Neoadjuvant Chemotherapy;   Procedure: Laparoscopic gastrectomy;   Procedure: Open gastrectomy;   Drug: Adjuvant Chemotherapy
Sponsors:   Peking University;   Beijing Municipal Science & Technology Commission
Active, not recruiting

Efficacy of HIPEC in the Treatment of Locally Advanced Gastric Cancer After radIcal Gastrectomy With D2

Condition:   Gastric Cancer
Interventions:   Procedure: D2 lymphadenectomy;   Procedure: Hyperthermic Intraperitoneal Chemotherapy;   Drug: Systemic chemotherapy (XELOX or SOX regimens)
Sponsors:   Affiliated Tumor Hospital of Guangzhou Medical University;   Tianjin Medical University Cancer Institute and Hospital;   Nanfang Hospital of Southern Medical University;   Zhejiang Cancer Hospital;   The Second Hospital of Hebei Medical University;   Chinese PLA General Hospital;   Henan Cancer Hospital;   Harbin Medical University;   Central South University;   Guangdong General Hospital;   Wuhan Union Hospital, China;   Sun Yat-sen University;   Hebei Medical University Fourth Hospital;   Guangdong Provincial Hospital of Traditional Chinese Medicine

Albumin Bound Paclitaxel Plus S-1 as the First Line Chemotherapy in Advanced or Recurrent Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Drug: Albumin Bound Paclitaxel;   Drug: S-1
Sponsor:   Sun Yat-sen University

Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer

Condition:   Gastric Cancer
Interventions:   Drug: Capecitabine/cisplatin;   Drug: S-1/cisplatin;   Drug: Capecitabine/oxaliplatin;   Drug: 5-fluorouracil/oxaliplatin;   Drug: Capecitabine;   Drug: S-1;   Drug: 5-fluorouracil
Sponsors:   Seoul National University Hospital;   Ministry of Health & Welfare, Korea;   Korean Cancer Study Group

Adjuvant Capecitabine Versus Observation Alone in Curatively Resected Stage IB Gastric Cancer

Condition:   Gastric Cancer
Intervention:   Drug: capecitabine
Sponsors:   Asan Medical Center;   Roche Pharma AG

Dovitinib for Gastric Cancer With FGFR2 Amplification

Condition:   Gastric Cancer
Intervention:   Drug: Dovitinib
Sponsors:   Asan Medical Center;   Novartis

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