Endometrial Cancer

About Endometrial Cancer Clinical Trials (Click to Open)

Join Clinical Trials for Endometrial Cancer

General Purpose:

Endometrial Cancer Clinical Trials

The endometrium is the tissue that lines the uterus, and it too can be affected by cancer. In fact, over 47,000 new cases of endometrial cancer are estimated to be diagnosed in 2012 in the United States, and 8,000 will likely die from the disease. The treatment for endometrial cancer generally depends on the extent of the tumor, and whether or not it has begun to invade the muscle layer of the uterus.

It also depends on other factors as well, including the grade of the tumor. Tumor grade is determined by examining a tissue sample of the tumor under a microscope. High-grade tumors tend to grow faster than low-grade tumors, which can help to estimate prognosis and guide treatment options. In addition to grade, the woman’s age and general health status are also taken into consideration when deciding on a method of treatment.

Clinical trials for endometrial cancer currently are currently focused on more effective methods of detecting and treating endometrial cancer. In addition, research is also looking into genetic influences that cause endometrial cancer to develop in the first place, as well as run in families. Finally, new surgical options for treatment are also being investigated.

What Will Clinical Trials for Endometrial Cancer Be Like?

Endometrial cancer clinical trials may involve many common tests and procedures; however, the ultimate design of the particular study will determine which specific procedures you will undergo. Examples of specific tests and procedures that may be used in a clinical trial for endometrial cancer include the following:Endometrial Cancer Clinical Trials

  • Physical exam and detailed family history information
  • Pelvic exam
  • Pap smear
  • Blood and/or tissue sample for the purposes of conducting genetic testing.
  • If the study is evaluating a new type of medication or vaccine, blood and/or urine tests may be performed to monitor how your body metabolizes the medication or how effectively your body has responded to the vaccine.
  • Imaging procedures such computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI) scans. These imaging procedures are non-invasive and provide detailed pictures of areas inside your body.   
  • Vaginal ultrasound
  • Surgery
  • Biopsy
  • Quality of life assessments to evaluate how your cancer is impacting your ability to perform activities of daily living.
  • Pain assessments

Typical Endometrial Cancer Clinical Trial Protocol:

There is a variety of research currently being conducted for women with endometrial cancer. Sample clinical trials for endometrial cancer might include the following:

  • A clinical trial to compare the effectiveness of different types of radiation therapy following surgery to remove the uterus
  • A clinical trial to compare the use of standard chemotherapy plus radiation therapy versus standard chemotherapy alone to treat endometrial cancer.
  • A clinical trial designed to evaluate if long-term use of hormonal contraceptives (e.g., birth control pills) is associated with an increased risk of endometrial cancer.
  • A study to evaluate genetic mutations in endometrial cancers and determine if the presence of certain mutations indicate a more favorable response to a particular chemotherapy drug.
  • A study to determine which type of surgical method used to remove the uterus leads to the fewest side effects for patients.

A brief word about randomized trials and placebos:

Clinical trials for endometrial cancer, like many clinical trials, involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process Endometrial Cancer Clinical Trialsknown as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone.

In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment. This is rarely done in cancer clinical trials; however it may occasionally be necessary from a scientific standpoint.

Placebo-only trials will only be done when ethically appropriate and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular type of cancer and clinical situation.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, including your disease stage, treatment history, and a variety of clinical findings. Therefore, it is important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you will want to have on hand Endometrial Cancer Clinical Trialsinclude:

  • The name, location, size, stage, and cell type of your cancer, as well as the locations of any metastases you have. Also know these details for any prior cancer you have had.
  • Know your performance status, which estimates how well you perform normal activities of daily living. Examples: Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know your treatment history, including chemotherapy, radiation therapy, immunotherapy, and/or surgery.
  • Know your blood cell counts, liver function test results, and kidney function test results.

Suggested Search Terms:

“clinical trials for endometrial cancer,” “endometrial cancer treatment,” “endometrial cancer chemotherapy,” “endometrial cancer radiation therapy,” “endometrial cancer management,” “endometrial cancer surgery,” “advanced endometrial cancer,” “high grade endometrial cancer,” “low grade endometrial cancer,” and “endometrial cancer screening.”

Current Search Term:

“Endometrial Cancer”

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Compare the Performance of Targeted Biopsy Versus Aspiration Biopsy With a Pipette for the Diagnosis of Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Procedure: Blind biopsy with a pipette;   Procedure: Targeted biopsy using hysteroscopy
Sponsor:   Brugmann University Hospital
Not yet recruiting - verified April 2017


An Endometrial Cancer Study of Sodium Cridanimod in Conjunction With Progestin Therapy


Condition:   Endometrial Cancer
Interventions:   Drug: Sodium Cridanimod;   Drug: progestin therapy
Sponsor:   Xenetic Biosciences, Inc.
Not yet recruiting - verified April 2017


Mirena® ± Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Drug: Metformin;   Device: Mirena®
Sponsor:   Chang Gung Memorial Hospital
Enrolling by invitation - verified December 2016


Effect of Uterine Manipulator on Recurrence and Mortality of Endometrial Cancer


Condition:   Endometrial Cancer
Intervention:   Device: UTERINE MANIPULATOR
Sponsor:   Università degli Studi dell'Insubria
Completed - verified November 2016


Study of Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer


Condition:   Metastatic Endometrial Cancer
Intervention:   Drug: Avelumab
Sponsors:   Dana-Farber Cancer Institute;   Pfizer
Recruiting - verified February 2017


Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer


Condition:   Endometrial Cancer
Intervention:   Procedure: Sentinel Lymph Node Dissection
Sponsor:   University of Miami
Recruiting - verified May 2017


SLNM in Endometrial Cancer Combined With OSNA


Condition:   Endometrial Cancer
Intervention:   Device: RD-100i, OSNA
Sponsors:   Charles University, Czech Republic;   University Hospital Pilsen
Recruiting - verified January 2017


Enzalutamide in Combination With Carboplatin and Paclitaxel in Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Drug: Enzalutamide;   Drug: Carboplatin;   Drug: Paclitaxel
Sponsors:   M.D. Anderson Cancer Center;   Astellas Pharma Inc;   Medivation, Inc.;   National Comprehensive Cancer Network
Recruiting - verified March 2017


Pre-operative Studies for Prediction of Lymph Nodes Involvement in Endometrial Cancer Patients


Condition:   Endometrial Cancer
Interventions:   Device: ultrasound;   Other: blood test
Sponsor:   Meir Medical Center
Recruiting - verified September 2016


Study of LY3023414 for the Treatment of Recurrent or Persistent Endometrial Cancer


Conditions:   Endometrial Cancer;   Recurrent Endometrial Cancer
Intervention:   Drug: LY3023414
Sponsors:   Memorial Sloan Kettering Cancer Center;   Eli Lilly and Company
Recruiting - verified February 2017


ENdometrial Cancer SURvivors' Follow-up carE (ENSURE): Less is More?


Condition:   Endometrial Cancer
Intervention:   Other: Reduced follow-up schedule
Sponsors:   Comprehensive Cancer Centre The Netherlands;   Dutch Cancer Society;   Maastricht University Medical Center;   Leiden University Medical Center
Recruiting - verified January 2017


Phase II Study of Intrauterine Device (IUD) Alone or in Combination With Everolimus in Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Device: Levonorgestrel Intrauterine Device (LIUD);   Drug: Everolimus;   Behavioral: Questionnaire
Sponsors:   M.D. Anderson Cancer Center;   Novartis
Recruiting - verified October 2016


Endometrial Cancer Biomarker Changes Following Exposure to Metformin


Condition:   Endometrial Cancer
Intervention:   Drug: Metformin
Sponsor:   Jewish General Hospital
Withdrawn - verified August 2016


Follow-up of Endometrial Cancer Patients


Condition:   Endometrial Cancer
Intervention:   Other: Instruction in self-referral
Sponsors:   Odense University Hospital;   Research Unit of General Practice, Odense;   University of Southern Denmark;   Danish Cancer Society
Active, not recruiting - verified April 2017


Lymph Node Mapping in Patients With Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Procedure: sentinel lymph node detection;   Drug: indocyanine green solution;   Drug: isosulfan blue;   Procedure: sentinel lymph node biopsy
Sponsor:   Ohio State University Comprehensive Cancer Center
Active, not recruiting - verified February 2017


Phase III Study Comparing 3D Conformal Radiotherapy and Conformal Radiotherapy IMRT to Treat Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Radiation: 3D conformational radiation;   Radiation: IMRT
Sponsors:   Centre Oscar Lambret;   National Cancer Institute, France
Active, not recruiting - verified July 2016


Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery


Condition:   Endometrial Cancer
Intervention:   Procedure: Fluorescence-guided sentinel lymph node detection
Sponsor:   Swedish Medical Center
Completed - verified November 2016


Treatment of Endometrial Cancer


Condition:   Endometrial Cancer
Intervention:   Procedure: Lymphadenectomy
Sponsor:   Frederick R. Ueland, M.D.
Active, not recruiting - verified October 2016


Study of Lenvatinib in Subjects With Advanced Endometrial Cancer and Disease Progression


Condition:   Endometrial Cancer
Intervention:   Drug: Lenvatinib
Sponsor:   Eisai Inc.
Completed - verified November 2016


Letrozole and RAD001 With Advanced or Recurrent Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Drug: Letrozole;   Drug: RAD001 (Everolimus)
Sponsors:   M.D. Anderson Cancer Center;   Novartis
Active, not recruiting - verified February 2017


Trial Between Two Follow up Regimens With Different Test Intensity in Endometrial Cancer Treated Patients


Condition:   Endometrial Cancer
Interventions:   Procedure: Intensive/Low-Risk follow up (IA G1; IA G2);   Procedure: Intensive/High-Risk follow up (≥ IA G3);   Procedure: Minimalist/Low-Risk follow up (IA G1; IA G2);   Procedure: Minimalist/High-Risk follow up (≥ IA G3)
Sponsors:   Azienda Ospedaliera San Giovanni Battista;   Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte;   Rete Oncologica Piemonte, Valle d'Aosta
Recruiting - verified April 2017


Ridaforolimus in Treating Patients With Recurrent Metastatic and/or Locally Advanced Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Drug: ridaforolimus;   Genetic: gene expression analysis;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis
Sponsor:   NCIC Clinical Trials Group
Completed - verified February 2015


Risk Factors for Endometrial Cancer in Black Women


Condition:   Endometrial Cancer
Interventions:   Other: questionnaire administration;   Other: study of socioeconomic and demographic variables;   Procedure: evaluation of cancer risk factors
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI);   The City College of New York;   DOWNSTATE MED/KINGS CO/BKLYN;   Montefiore Hospital
Active, not recruiting - verified March 2017


Physical Activity After Endometrial Cancer


Condition:   Endometrial Cancer
Interventions:   Behavioral: Personalized Exercise Program;   Behavioral: Questionnaire;   Behavioral: Suggested Exercise Program
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified November 2016


Letrozole in the Treatment of Advanced or Recurrent Hormone Receptor Positive Endometrial Cancer


Condition:   Endometrial Cancer
Intervention:   Drug: Letrozole
Sponsor:   Novartis Pharmaceuticals
Completed - verified November 2016

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