Cervical Cancer

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Clinical Trials for Cervical Cancer

General Purpose:

Cervical cancer is generally a slow-growing cancer that produces very few symptoms until it has progressed considerably. Fortunately, it can be detected at an early stage through the use of routine pap smears.

Research related to cervical cancer is focused on addressing a number of issues, examples of which include: improved screening methods for detecting cervical cancer at an early stage; evaluating new and better treatment options for women with cervical cancer; and testing new vaccines to protect against its development (as the majority of all cervical cancer cases are caused by a human papillomavirus [HPV] infection).

What Will Clinical Trials for Cervical Cancer Be Like?

When participating in clinical trials for cervical cancer, there are a few basic tests and Clinical Trials for Cervical Cancerprocedures you may receive; however, the ultimate design of the particular study will determine which specific procedures you will undergo. Some of the following tests and procedures may be used during cervical cancer clinical trials:

  • Physical exam
  • Pelvic exam
  • Pap smear
  • Vaginal or abdominal ultrasound
  • Computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI) scans. These imaging procedures are non-invasive and provide detailed pictures of areas inside your body.
  • If the study is evaluating a new type of medication or vaccine, blood and/or urine tests may be performed to monitor how your body metabolizes the medication or how effectively your body has responded to the vaccine.
  • Quality of life assessments to evaluate how your cancer is impacting your ability to perform activities of daily living.

Typical Cervical Cancer Clinical Trial Protocol:

Current research is focused on new ways to prevent and treat cervical cancer, vaccine development, drugs that target specific genetic changes that cause a cell to become cancerous, and drug-treatment for pre-cancerous cells. Examples of possible clinical trials include the following:

  • A long-term study in which healthy individuals receive a newly developed HPV vaccine and are followed to determine its long-term effects on the risk of cervical cancer.
  • A clinical trial designed to determine if a newly-developed drug that blocks a cancer cell’s ability to grow can help women with advanced cervical cancer live longer.
  • A clinical trial designed to determine if treatment with high-heat radiofrequency signals directed at the site of the cervical tumor can more effectively prevent the cancer from returning than conventional radiation therapy.
  • A clinical trial designed to determine if application to the cervix of a new drug that kills pre-cancerous cervical cells is more effective than standard therapy.

A brief word about randomized trials and placebos:

Clinical Trials for Cervical CancerMany clinical trials, to include clinical trials for cervical cancer, involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

This is rarely done in cancer clinical trials; however it may occasionally be necessary from a scientific standpoint. Placebo-only trials will only be done when ethically appropriate and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular type of cancer and clinical situation.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, Clinical Trials for Cervical Cancerincluding your disease stage, treatment history, and a variety of clinical findings. Therefore, it is important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you will want to have on hand include:

  • The name, location, size, stage, and cell type of your cancer, as well as the locations of any metastases you have. Also know these details for any prior cancer you have had.
  • Know your performance status, which estimates how well you perform normal activities of daily living. Examples: Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know your treatment history, including chemotherapy, radiation therapy, immunotherapy, and/or surgery.
  • Know your blood cell counts, liver function test results, and kidney function test results.

Suggested Search Terms:

“cervical cancer screening,” “cervical cancer HPV,” “cervical cancer vaccine,” “cervical cancer prevention,” “cervical cancer treatment,” “advanced cervical cancer,” “recurrent cervical cancer,” and “cervical cancer early detection.”

Current Search Term:

“Cervical Cancer”

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Individualized Precise Radiotherapy With the Guidance of Radiosensitivity of Locally Advanced Cervical Cancer


Condition:   Cervical Cancer
Interventions:   Biological: 18F-FDG PET/CT and Comet assay guide RapidArc;   Biological: 18F-FDG PET/CT and Comet assay guide IMRT;   Biological: RapidArc;   Biological: 7f-IMRT
Sponsor:   Nanjing Medical University
Recruiting - verified May 2017


Single Application Brachytherapy in Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Radiation: Single application multi-fraction brachytherapy
Sponsor:   Tata Memorial Hospital
Not yet recruiting - verified April 2017


Image Based Brachytherapy in Locally Advanced Cervical Cancers - a Randomized Controlled Trial


Condition:   Cervical Cancer
Interventions:   Radiation: Magnetic Resonance Image based Brachytherapy;   Radiation: Conventional Radiograph based Brachytherapy
Sponsor:   Tata Memorial Hospital
Recruiting - verified December 2016


Cervical Cancer Radiotherapy by Use of VMAT, Individualized Polyradiosensitization and Interstitial Brachytherapy


Condition:   Cervical Cancer
Interventions:   Radiation: Volumetric Arc Radiotherapy;   Radiation: Interstitial brachytherapy;   Drug: Cisplatin;   Drug: Gemcitabine;   Genetic: PIK3CA;   Genetic: KRAS;   Genetic: BRAF;   Genetic: RRM1
Sponsor:   The National Center of Oncology, Azerbaijan
Recruiting - verified November 2016


Cervical Cancer in French Guiana: Screening Between 2006-2011


Condition:   Cervical Cancer
Intervention:   Other: cross sectional
Sponsor:   Centre Hospitalier de Cayenne
Completed - verified September 2016


Sentinel Lymph Node Biopsy in Patients With Early Stages Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Procedure: Sentinel lymph node biopsy
Sponsor:   Charles University, Czech Republic
Recruiting - verified June 2016


Phase II Study of Pazopanib and Topotecan in Cervical Cancer


Condition:   Cervical Cancer
Interventions:   Drug: Pazopanib;   Drug: Topotecan;   Behavioral: Phone Call
Sponsors:   M.D. Anderson Cancer Center;   GlaxoSmithKline
Withdrawn - verified August 2016


Cervical Cancer Screening Study in Brazil


Condition:   Cervical Cancer
Interventions:   Procedure: Wide-Field White Light Imaging;   Drug: Acetic Acid;   Drug: Proflavine Solution;   Procedure: Wide-Field Fluorescence Imaging
Sponsor:   M.D. Anderson Cancer Center
Active, not recruiting - verified March 2017


A Study of INO-3112 DNA Vaccine With Electroporation in Patients With Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Biological: 1.1 mL of INO-3112 delivered via IM EP
Sponsor:   Inovio Pharmaceuticals
Active, not recruiting - verified February 2017


Study of the Therapeutic Vaccine (ISA101/ISA101b) to Treat Advanced or Recurrent Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Drug: ISA101/ISA101b
Sponsors:   ISA Pharmaceuticals;   Dutch Cancer Society
Recruiting - verified April 2017


Clinic-based Intervention to Promote Cervical Cancer Prevention Behaviors


Condition:   Cervical Cancer
Interventions:   Behavioral: Step Up to Prevention;   Behavioral: Step Up to Prevention: knowledge;   Behavioral: Step Up to Prevention:belief;   Behavioral: Offered HPV vaccine only
Sponsor:   University of Pennsylvania
Active, not recruiting - verified February 2017


Adjuvant Chemotherapy for Locally Advanced Cervical Cancer


Condition:   Uterine Cervical Cancer
Interventions:   Radiation: Pelvic radiation;   Drug: Cisplatin;   Drug: Paclitaxel;   Drug: Carboplatin
Sponsors:   Siriwan Tangjitgamol, MD;   National Research Council of Thailand;   Navamindradhiraj University;   Chiang Mai University;   Prince of Songkla University;   Bhumibol Adulyadej Hospital;   Lopburi Cancer Hospital;   Ubonratchathani Cancer Hospital;   Udonthani Cancer Hospital;   Chonburi Cancer Hospital;   Lampang Cancer Hospital;   Health Intervention and Technology Assessment Program;   Rajburi Hospital
Recruiting - verified April 2017


Randomized Trial of In-Home Cervical Cancer Screening in Underscreened Women


Condition:   Cervical Cancer
Interventions:   Behavioral: Mailed in-home high-risk HPV testing kit;   Other: Usual care
Sponsors:   University of Washington;   Group Health Cooperative;   University of Texas Southwestern Medical Center;   National Cancer Institute (NCI);   University of California, Davis
Enrolling by invitation - verified February 2017


GSK1120212+GSK2141795 for Cervical Cancer


Condition:   Cervical Cancer
Interventions:   Drug: GSK1120212 (trametinib);   Drug: GSK2141795
Sponsors:   Dana-Farber Cancer Institute;   Novartis;   National Comprehensive Cancer Network
Terminated - verified August 2016


High Dose Intensity Modulated Radiation Therapy in the Cervical Cancer With Metastatic Lymphadenopathies.


Condition:   Cervical Cancer
Intervention:   Radiation: Tomotherapy
Sponsors:   National Cancer Center, Korea;   Keimyung University Dongsan Medical Center
Recruiting - verified July 2016


Faith Moves Mountains: An Appalachian Cervical Cancer Prevention Project


Condition:   Cervical Cancer
Intervention:   Behavioral: Lay health advisor visits and newsletter
Sponsors:   Nancy Schoenberg;   National Cancer Institute (NCI)
Completed - verified June 2011


Advanced Cervical Cancer Trial in India


Condition:   Cervical Cancer
Interventions:   Drug: Interferon, Retinoic Acid and radiation;   Drug: Cisplatin and radiation
Sponsors:   James Graham Brown Cancer Center;   University of Louisville
Completed - verified November 2016


Prophylactic Irradiation of the Para-Aortic Lymph Nodes in Locally Advanced Uterine Cervical Cancer


Condition:   Cervical Cancer
Interventions:   Radiation: EFI;   Radiation: Pelvic RT
Sponsor:   National Cancer Center, Korea
Active, not recruiting - verified July 2016


Cervical Cancer Detection Using Optical Spectroscopy


Condition:   Cervical Cancer
Interventions:   Device: Optical Spectroscopy Bench-Top System;   Device: Portable Optical Spectrometer;   Device: Transvaginal colposcope
Sponsor:   Duke University
Recruiting - verified April 2017


Radical Trachelectomy for Women With Early Stage Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Behavioral: Questionnaires
Sponsor:   M.D. Anderson Cancer Center
Recruiting - verified November 2016


Endothelial Progenitor Cells in Cervical Cancer Patients Receiving Chemoradiation


Condition:   Cervical Cancer
Intervention:  
Sponsors:   Mackay Memorial Hospital;   National Science Council, Taiwan
Recruiting - verified March 2017


Sexual Functioning in Cervical Cancer Survivors


Condition:   Cervical Cancer
Intervention:   Behavioral: Questionnaire
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified September 2016


DNA Array Analysis of Patients With Cervical Cancer


Condition:   Cervical Cancer
Intervention:   Procedure: Tumor Biopsies
Sponsor:   M.D. Anderson Cancer Center
Active, not recruiting - verified October 2016


HPV Testing for Cervical Cancer Screening Study


Condition:   Cervical Cancer Screening
Interventions:   Procedure: Cervical cancer screening undertaken by HPV testing as a single primary screening test with cytology triage of women who are HPV positive;   Procedure: Cervical cancer screening undertaken by HPV testing as a single primary screening test with cytology triage of women who are HPV positive
Sponsors:   University of British Columbia;   Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified May 2017


Docetaxel and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Cervical Cancer


Condition:   Cervical Cancer
Interventions:   Drug: docetaxel;   Radiation: cesium Cs 137;   Radiation: radiation therapy
Sponsor:   University of Miami
Withdrawn - verified December 2016

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