Cancer Pain Management

About Cancer Pain Management Clinical Trials (Click to Open)

Join Clinical Trials for Cancer Pain Management

Cancer Pain ManagementGeneral Purpose: 

Cancer can be a painful disease, both emotionally and physically. One out of every three people who undergo cancer treatment will experience physical pain. Moreover, individuals with advanced cancer have an even higher chance of experiencing pain. Regardless of where you are in terms of your cancer staging, diagnosis, and treatment, the pain that arises as a result can make living life difficult.

Tumors have the potential to press on nerves, bones, or organs and in doing so, result in pain. Cancer-related pain can also arise due to chemicals that the tumors release into the body. Finally, various treatments for cancer (including chemotherapy, radiation therapy, and surgery) can also have painful side effects.

If you have cancer and are experiencing pain, effectively managing that pain is likely to be high on your list of priorities. Research is constantly looking at new and more effective ways to manage cancer pain, and clinical trials can often provide you with access to those ways.

What Will Cancer Pain Management Clinical Trials Be Like?

If surgery, radiation therapy, and chemotherapy are unable to decrease the tumor burden and adequately relieve cancer-related pain, pain medications can generally help Cancer Pain Managementto relieve pain.

Examples of these types of medications include over the counter pain medications (Tylenol, Advil, etc.), weak opium-derived (i.e., opioid) prescription painkillers (e.g., codeine), and stronger opioid prescription painkillers (e.g., morphine, OxyContin, fentanyl). Other therapeutic measures, such as massage, exercise, and psychotherapy may also be utilized in clinical trials designed to address cancer-related pain.

The types of tests and assessments used in a cancer pain management clinical trial will depend on which of these therapeutic options (i.e., medications, psychotherapy) are being investigated.

Although there are a few basic tests and procedures you may receive, the ultimate design of the particular study will determine which specific procedures you will undergo. Below are a few possible components of cancer pain management clinical trials:

  • Physical exam
  • If the study is evaluating a new type of medication or vaccine, blood and/or urine tests may be performed to monitor how your body metabolizes the medication or how effectively your body has responded to the vaccine.
  • Pain and quality of life assessments (either online, using pen-and-paper, or over the phone with a research nurse) to evaluate the intensity of your pain, how your cancer pain is impacting your life, and/or how your pain is improving in response to the treatment
  • For medication-related trials, you may be asked to keep a medication diary and/or bring your pill bottles in to your clinic visits so that pills may be counted. These activities help researchers observe how compliant you are with taking your medication

Typical Cancer Pain Management Clinical Trial Protocol:

Currently, research related to cancer pain management is extensive. Specific examples of clinical trials might include the following:

  • A study that utilizes in-home visits from a research nurse to educate and coach cancer patients about successful self-management of pain through behavioral interventions.
  • A study that evaluates how a newly-developed synthetic opioid medication controls pain due to bone metastases when compared to a standard opioid therapy.
  • A study that evaluates how patients’ reluctance to ask doctors for additional pain medication impacts pain level and psychological status.
  • A study that evaluates the symptoms associated with treatment for cancer-related pain.

A brief word about randomized trials and placebos:

Cancer Pain ManagementMany clinical trials involve the comparison of an investigational treatment to a “standard” treatment. Some studies determine which therapy a patient receives through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

On occasion, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or “sham” treatments that are identical in appearance to the active treatment but have no therapeutic value.

Placebos are necessary to help determine if adverse effects that occur during the clinical trial are the result of the investigational treatment or due to some other factor. They also allow researchers to measure the effects of the active treatment and observe what would have happened without it.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

This is rarely done in cancer clinical trials; however it may occasionally be necessary from a scientific standpoint. Placebo-only trials will only be done when ethically appropriate and when patients have been adequately informed that they may end up receiving the placebo rather than the active treatment.

It is very important to note, however, that no one should ever participate in such a placebo trial when there is a widely available and highly effective standard treatment already in existence for their particular type of cancer and clinical situation.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on many factors, including your disease stage, treatment history, and a variety of clinical findings. Therefore, it is important to know many details pertaining to your specific diagnosis when searching for clinical trials. Examples of the details you will want to have on hand include:

  • The name, location, size, stage, and cell type of your cancer, as well as the locations of any metastases you have. Also know these details for any prior cancer you have had.
  • Know your performance status, which estimates how well you perform normal activities of daily living. Examples: Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know your treatment history, including chemotherapy, radiation therapy, immunotherapy, and/or surgery.
  • Know your blood cell counts, liver function test results, and kidney function test results.

Additional Suggested Search Terms:

“interventional cancer pain management,” “cancer pain management opioid,” “cancer pain management alternative therapies,” “cancer pain management clinical trials,” and “cancer pain management techniques.”

Current Search Term:

“Cancer Pain”

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Effect of Good Pain Management (GPM) Ward Program on Moderate to Severe Cancer Pain Patients


Conditions:   Cancer;   Pain
Interventions:   Other: Good pain management (GPM) procedure;   Other: Current practice procedure
Sponsor:   Taiwan Mundipharma Pharmaceuticals Ltd.
Recruiting - verified May 2017


Intranasal (NAS) Ketamine for Cancer Pain


Conditions:   Cancer;   Pain
Intervention:   Drug: Intranasal ketamine
Sponsor:   Emory University
Not yet recruiting - verified May 2017


Radiofrequency and Chemical Neurolysis of Thoracic Splanchnic Nerve for Abdominal Cancer Pain


Condition:   Abdominal Cancer
Interventions:   Device: Radiofrequency generator device;   Drug: Lidocaine;   Device: C arm fluoroscopic device;   Drug: Ethyl alcohol
Sponsor:   South Egypt Cancer Institute
Recruiting - verified February 2017


Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies


Conditions:   Osteoarthritis;   Cancer Pain;   Recurrent Low Back Pain
Intervention:   Drug: Investigational medical product (IMP) administered in parent study
Sponsors:   Pfizer;   Eli Lilly and Company
Not yet recruiting - verified May 2017


Characterisation and Epidemiology of Breakthrough Cancer Pain in Spain


Condition:   Breakthrough Cancer Pain
Intervention:   Other: No Intervention
Sponsor:   Takeda
Recruiting - verified May 2017


Praxis Evaluation of a Pain Self-management Support Intervention for Oncology Patients: A Stepped Wedge Design Study


Condition:   Cancer Pain Self-management
Intervention:   Behavioral: ANtiPain
Sponsors:   University of Vienna;   Martin-Luther-Universität Halle-Wittenberg;   University of Lausanne
Recruiting - verified February 2017


Long-term Effects of Methadone for Cancer Pain


Condition:   Cancer Pain
Intervention:  
Sponsor:   Hospices Civils de Lyon
Recruiting - verified August 2016


Quality of Life Study in Patients With Breakthrough Cancer Pain Treated in Radiation Oncology Services With Palliative Intent


Condition:   Breakthrough Pain
Intervention:   Other: No intervention
Sponsor:   Angelini Farmacéutica
Recruiting - verified July 2016


Validation and Assessment of Patient Adherence to Opioids for Cancer Pain Using MMAS 8 Pain Clinic


Condition:   Chronic Cancer Pain
Intervention:  
Sponsor:   Tata Memorial Centre
Completed - verified April 2017


Optimizing Delivery of a Behavioral Cancer Pain Intervention Using a SMART


Conditions:   PCST-Full (Pain Coping Skills Training);   PCST-Brief
Interventions:   Behavioral: Pain Coping Skills Training Full;   Behavioral: Pain Coping Skills Brief
Sponsor:   Duke University
Recruiting - verified November 2016


A mHealth Behavioral Cancer Pain Protocol for Medically Underserved Communities


Condition:   Breast Cancer
Intervention:   Behavioral: Device: smartphone
Sponsor:   Duke University
Recruiting - verified March 2017


An Interventional Study for Patients With Cancer Pain to Evaluate the Efficacy and Safety of OxyNorm® Compared to Morphine Sulfate Through IV Continuous Infusion


Condition:   Cancer Pain
Interventions:   Drug: Oxycodone Hydrochloride;   Drug: Morphine Sulphate
Sponsor:   Mundipharma Korea Ltd
Completed - verified January 2017


Precision Medicine Guided Treatment for Cancer Pain


Conditions:   Pain;   CYP2D6 Polymorphism
Interventions:   Genetic: CYP2D6;   Behavioral: Brief Pain Inventory-Short Form (BPI-SF);   Behavioral: M.D. Anderson Symptom Inventory (MDASI);   Genetic: OPRM1
Sponsors:   University of Florida;   H. Lee Moffitt Cancer Center and Research Institute
Recruiting - verified December 2016


Transcutaneous Electrical Nerve Stimulation (TENS) for Advanced Cancer Pain Patients


Condition:   Advanced Cancer
Interventions:   Device: Modulated TENS;   Device: Placebo TENS
Sponsor:   University Hospital Freiburg
Recruiting - verified May 2017


Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking Background Opioid Therapy.


Conditions:   Neoplasm Metastasis;   Musculoskeletal Pain
Intervention:   Drug: Tanezumab
Sponsors:   Pfizer;   Eli Lilly and Company
Recruiting - verified May 2017


Comparison of Oral Morphine Versus Nasal Ketamine Spray With Chitosan in Cancer Pain Outpatients


Conditions:   Cancer: Breakthrough Pain;   Cancer: Extreme Pain on Movement
Interventions:   Drug: Morphine;   Drug: Ketamine;   Drug: Placebo;   Drug: Chitosan
Sponsor:   University Hospital, Basel, Switzerland
Recruiting - verified November 2016


Cordotomy for Refractory Cancer Pain


Conditions:   Advanced Cancers;   Pain
Interventions:   Procedure: Cordotomy;   Behavioral: Pain/Symptom Questionnaire;   Procedure: Sharpness Sensory Testing;   Procedure: Heat Pain Sensory Testing
Sponsors:   M.D. Anderson Cancer Center;   American Cancer Society, Inc.
Recruiting - verified March 2017


Mobile Pain Coping Skills Training for Cancer Pain


Conditions:   Mobile Pain Coping Skills Training;   In Person Pain Coping Skills Training
Intervention:   Behavioral: Pain Coping Skills Training
Sponsor:   Duke University
Recruiting - verified October 2016


Oxcarbazepine Plus Morphine in Patients With Refractory Cancer Pain


Condition:   Cancer
Interventions:   Drug: Morphine;   Drug: Oxcarbazepine
Sponsor:   Costantine Albany
Terminated - verified January 2017


Observational Study of Incidence of Breakthrough Cancer Pain and How it is Treated


Condition:   Advanced Cancer
Intervention:  
Sponsor:   National Cancer Institute, Naples
Recruiting - verified March 2017


Nasal Fentanyl for Chronic Cancer Pain


Conditions:   Cancer;   Pain
Interventions:   Drug: intranasal fentanyl spray;   Drug: slow release morphine
Sponsors:   Norwegian University of Science and Technology;   St. Olavs Hospital;   Fondazione IRCCS Istituto Nazionale dei Tumori, Milano;   L'Hospitalet de Llobregat;   University Hospital, Bonn;   Cantonal Hospital of St. Gallen;   Maastricht University Medical Center;   Flinders University
Recruiting - verified January 2017


Targin Cancer Pain


Conditions:   Cancer;   Pain
Interventions:   Drug: Oxycodone/Naloxone;   Drug: Oxycodone
Sponsor:   Mundipharma (China) Pharmaceutical Co. Ltd
Completed - verified August 2015


PROspective Non-interventional Open laBEl Trial for TARGIN in Korean Patients With Cancer Pain


Condition:   Cancer
Intervention:   Drug: Oxycodone/Naloxone
Sponsor:   Mundipharma Korea Ltd
Completed - verified July 2016


Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.


Conditions:   Cancer;   Pain
Interventions:   Other: analgesic ladder;   Other: analgesic ladder
Sponsors:   University of Edinburgh;   NHS Lothian
Completed - verified December 2015


Corticosteroids for Cancer Pain


Conditions:   Cancer;   Pain
Interventions:   Drug: Methylprednisolone;   Drug: Placebo
Sponsor:   Norwegian University of Science and Technology
Completed - verified July 2016

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