Breast Cancer

About Breast Cancer Clinical Trials (Click to Open)

Join Clinical Trials for Breast Cancer

Clinical Trials for Breast CancerGeneral Purpose:

Breast cancer is one of the most common and well-known cancers affecting women (and some men) today. Over 225,000 women in the United States, and 2,100 men, will be diagnosed with breast cancer during 2012. Fortunately, there are many effective therapies and clinical trials for breast cancer, which means that patients can often be cured of their cancer if it is detected early enough.

However, new treatments are constantly being evaluated through clinical trials, in addition to research investigating the potential causes of breast cancer – including environmental exposures, genetic mutations, and behavioral characteristics such as diet and exercise.

What Will Clinical Trials for Breast Cancer Be Like?

When participating in a breast cancer clinical trial, there are a few basic tests and procedures you may receive; however, the ultimate design of the particular study will determine which specific procedures you will undergo. The following tests and procedures are often used during breast cancer clinical trials:

  • Clinical breast exam during which your healthcare provider checks your breasts forClinical Trials for Breast Cancer lumps.
  • Mammogram
  • Ultrasound
    • Computed tomography (CT scan, or “CAT scan”) or magnetic resonance imaging (MRI). CT scans and MRI enable doctors to view more detailed pictures of areas inside your body than X-rays can reveal.
    • Biopsy
    • Blood tests to evaluate levels of hormones, proteins, and specific blood cells, and to look for various markers indicating response to investigational medication

Typical Protocol for Clinical Trials for Breast Cancer:

Clinical trials for breast cancer are plentiful and span a wide variety of topics, from symptom control, prevention, treatment, and improved screening. Possible examples include the following: 

  • Trials that compare the effectiveness of standard radiation therapy to the entire breast (following surgical removal of the breast tumor) with more targeted radiation therapy to a smaller area of the breast.
  • Clinical trials that evaluate the effectiveness of receiving chemotherapy prior to surgery to remove a breast tumor.
  • Clinical trials that assess certain lab tests to determine which, if any, can be useful to help predict how a woman will respond to a certain type of chemotherapy.
  • Clinical trials that investigate if hormone therapy administered prior to surgical removal of a breast tumor can help to shrink the size of the tumor and make it easier to remove.
  • Studies that investigate ways of improved control and treatment of side effects following surgery to remove breast tumors, such as treatments to reduce pain and improve overall quality of life.
  • Studies that involve the study of breast tumor tissue to better understand the genetic influences that play a role in the development of breast cancer.
  • Studies that investigate the effectiveness of alternative therapies, such as acupuncture or yoga, to help improve the side effects associated with breast cancer treatment, or to improve overall quality of life in breast cancer patients.

A brief word about randomized trials and placebos:

Clinical trials for breast cancer, as well as many other clinical trials involve the comparison of an investigational treatment to an existing or “standard” treatment for the cancer. The Clinical Trials for Breast Cancerexact therapy (i.e., investigational or standard) that each patient receives in such a trial is usually determined through a process known as randomization, in which patients are randomly assigned to receive either the investigational treatment or the standard treatment.

Sometimes, a trial will investigate the use of a standard treatment plus a new drug compared to standard treatment plus a placebo. Placebos are inactive or sham treatments that are identical to the active treatment; however they have no therapeutic value.

The purpose for using a placebo is to be certain that any adverse effects that occur during the clinical trial are actually the result of the investigational treatment and not some other factor. In these types of trials, all patients receive the standard treatment, while those randomized to the investigational treatment receive the additional drug.

In rare instances where no standard therapy exists, or when a new drug is being evaluated for the first time in a specific cancer, the investigational treatment might be compared to a placebo alone. In these types of trials, those patients who are randomized to the placebo group do not receive an active treatment.

This is rarely done in cancer clinical trials, however, and is only done when it is necessary from a scientific standpoint, is ethically appropriate, and when patients have been adequately informed that they may receive the placebo.

Therefore, it is important to understand that if you are interested in participating in a trial that involves the use of a placebo alone (i.e., without standard treatment because none exists), you may end up receiving the placebo rather than the active treatment being investigated.

Often times, patients are reluctant to join a trial that involves the use of a placebo for fear that they will not receive an active treatment. While that may occasionally be the case, individuals who receive placebos are necessary to clinical research because their response during the study allow researchers to better measure the effects of the active treatment being studied, and help the researchers observe what would have happened without the active treatment.

It is also important to understand that it is not appropriate for an individual to participate in a placebo-controlled trial when there is a widely available and highly effective standard treatment already in existence for their cancer.

Trial Eligibility and Medical Information Needed:

The type of clinical trial you may be eligible for often depends on whether you have been newly diagnosed with cancer, or if you have already received treatment. In addition, Clinical Trials for Breast Cancereligibility may also be determined based on the stage of your cancer.

Therefore, it is important to know the exact details of your cancer diagnosis when searching for clinical trials for breast cancer. Specific details you will want to make note of and have on hand include the following:

  • The official name of your cancer (e.g., ductal carcinoma in situ of the breast)
  • Knowledge of where your cancer first started. For example, if you have breast cancer that spread to the liver, it is still considered breast cancer.
  • Know your cancer’s cell type. This information can be located in your pathology report.
  • Know the size and location of your tumor.
  • Know the locations of any and all metastases that have been diagnosed.
  • Know the stage of your cancer. This describes the extent of your cancer, and whether it has spread to other sites in the body. Each individual cancer has its own staging system, so be sure to know and understand the staging system specific to breast cancer.
  • Know your prior history of cancer (e.g., if you were diagnosed with skin cancer prior to your diagnosis of breast cancer, be sure to have all the details pertaining to that diagnosis as well).
  • Know your current performance status, which is an assessment performed by your doctor to determine how well you are able to perform normal activities of daily living. Two common scales used to evaluate the performance of cancer patients include the Karnofsky Performance Scale (KPS) and the ECOG scale.
  • Know what treatments you have already received for your cancer. Examples might include chemotherapy, radiation therapy, hormone therapy, and/or surgery.
  • Know your bone marrow function test results, including your white blood cell count, platelet count, and hemoglobin/hematocrit.
  • Know your liver function test results, including bilirubin and transaminases.
  • Know your kidney function (also referred to as renal function) test result, which includes serum creatinine.

Suggested Search Terms:

“breast cancer treatment,” “breast cancer recurrence,” “breast cancer screening,” “breast cancer chemotherapy,” “breast cancer radiation therapy,” “breast cancer alternative therapy,” “breast cancer quality of life,” and “male breast cancer.” “clinical trials for breast cancer”

Current Search Term:

“Breast Cancer”

Add Comments or Questions

Supine MRI in Breast Cancer Patients Receiving Neoadjuvant Therapy

Condition:   Breast Cancer
Interventions:   Device: Supine MRI;   Other: Neoadjuvant Therapy;   Device: Ultrasound;   Device: Mammography;   Procedure: Standard of Care
Sponsor:   Dana-Farber Cancer Institute
Not yet recruiting - verified November 2016

Fulvestrant Plus Enzalutamide in ER+/Her2- Advanced Breast Cancer

Condition:   Breast Cancer
Intervention:   Drug: Fulvestrant with Enzalutamide
Sponsors:   University of Colorado, Denver;   United States Department of Defense
Not yet recruiting - verified March 2017

Real-Time Assessment Of Breast Cancer Lumpectomy Specimen Margins With Nonlinear Microscopy

Condition:   Breast Cancer
Interventions:   Device: nonlinear microscopy imaging of excised surgical margins;   Procedure: standard lumpectomy without nonlinear microscopy imaging
Sponsors:   Dana-Farber Cancer Institute;   Massachusetts Institute of Technology
Not yet recruiting - verified October 2016

Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III

Condition:   Breast Cancer
Sponsors:   Latin American Cooperative Oncology Group;   Ministry of Health, Brazil;   Avon Institute
Recruiting - verified February 2017

Improved Breast Cancer Therapy (I-BCT-1) in the Neoadjuvant and Metastatic Setting

Condition:   Breast Cancer
Interventions:   Drug: Carboplatin;   Drug: Paclitaxel
Sponsor:   Oslo University Hospital
Recruiting - verified May 2016

Predictive Clinical and Biological Parameters in Breast Cancer

Condition:   Breast Cancer
Intervention:   Genetic: molecular alteration
Sponsor:   Institut Paoli-Calmettes
Recruiting - verified October 2016

Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging

Condition:   Breast Cancer
Intervention:   Device: Diffuse Optical Spectroscopy Imaging
Sponsors:   University of California, Irvine;   American College of Radiology Imaging Network;   Massachusetts General Hospital;   University of Pennsylvania;   Dartmouth-Hitchcock Medical Center;   University of San Francisco;   M.D. Anderson Cancer Center;   Boston University;   Beckman Laser Institute University of California Irvine
Completed - verified February 2017

Vitamin D and Breast Cancer Biomarkers in Female Patients

Condition:   Breast Cancer
Interventions:   Dietary Supplement: vitamin D;   Other: placebo
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Active, not recruiting - verified June 2016

Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: Foretinib;   Drug: Lapatinib
Sponsor:   NCIC Clinical Trials Group
Completed - verified February 2015

Preoperative Accelerated Partial Breast Irradiation (APBI) for Women With Stage I and Select IIA Breast Cancer

Condition:   Breast Cancer
Intervention:   Other: Phase II - Preoperative Radiation followed by Lumpectomy.
Sponsor:   University of Maryland
Active, not recruiting - verified March 2017

Phase II Trial of EVEROLIMUS ± Trastuzumab in Hormone-Refractory Metastatic Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: Everolimus;   Biological: Trastuzumab
Sponsors:   Emory University;   Genentech, Inc.;   Novartis Pharmaceuticals
Active, not recruiting - verified November 2016

Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

Condition:   Breast Cancer
Interventions:   Other: laboratory biomarker analysis;   Other: medical chart review
Sponsors:   Vanderbilt-Ingram Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting - verified May 2017

Blood Glycan Biomarkers in Women With Stage IV Breast Cancer

Condition:   Breast Cancer
Interventions:   Other: Healthy Controls;   Other: Metastatic Breast Cancer;   Other: Non-cancer medical illness
Sponsor:   University of California, Davis
Active, not recruiting - verified January 2017

Collecting Tissue Samples for Future Research From Women Undergoing Surgery for Breast Cancer

Condition:   Breast Cancer
Sponsors:   Northwestern University;   National Cancer Institute (NCI)
Recruiting - verified November 2016

Sorafenib and Vinorelbine in Treating Women With Stage IV Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: sorafenib tosylate;   Drug: vinorelbine ditartrate
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Completed - verified January 2017

Exemestane in Treating Postmenopausal Women With Stage IV Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: exemestane;   Other: laboratory biomarker analysis;   Procedure: quality-of-life assessment;   Other: immunohistochemistry staining method
Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI)
Active, not recruiting - verified January 2017

Studying Urine and Blood Samples in Women With Newly Diagnosed Breast Cancer

Condition:   Breast Cancer
Interventions:   Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Other: medical chart review;   Other: questionnaire administration;   Procedure: evaluation of cancer risk factors
Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
Completed - verified October 2015

Long-Term Effect of Adolescent Diet on Hormones and Breast Cancer Risk in Women Previously Enrolled in the Dietary Intervention Study in Children

Condition:   Breast Cancer
Interventions:   Other: physiologic testing;   Other: questionnaire administration;   Procedure: breast imaging study;   Procedure: dual x-ray absorptometry;   Procedure: evaluation of cancer risk factors;   Procedure: magnetic resonance imaging
Sponsors:   Fox Chase Cancer Center;   National Cancer Institute (NCI)
Completed - verified April 2017

Docetaxel vs. Docetaxel-Gemcitabine in Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: Gemcitabine;   Drug: docetaxel
Sponsor:   Eli Lilly and Company
Completed - verified November 2016

Neoadjuvant Herceptin in Patients With Breast Cancer

Condition:   BREAST CANCER
Intervention:   Drug: Herceptin
Sponsors:   Mothaffar Rimawi;   Genentech, Inc.
Terminated - verified February 2017

Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Condition:   Breast Cancer
Intervention:   Drug: exemestane
Sponsors:   NCIC Clinical Trials Group;   Grupo Espanol de Investigacion del Cancer de Mama;   UNICANCER
Active, not recruiting - verified October 2016

Anastrozole in Preventing Breast Cancer in Postmenopausal Women at Increased Risk of Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: anastrozole;   Drug: placebo
Sponsor:   Queen Mary University of London
Active, not recruiting - verified March 2017

Celecoxib in Preventing Breast Cancer in At-Risk Premenopausal Women

Condition:   Breast Cancer
Intervention:   Drug: celecoxib
Sponsors:   University of Kansas Medical Center;   National Cancer Institute (NCI)
Completed - verified February 2017

Ceramide Cream in Treating Women With Cutaneous Breast Cancer

Condition:   Breast Cancer
Intervention:   Drug: ceramide
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified December 2016

Gemcitabine and Cisplatin in Treating Patients With Metastatic Breast Cancer

Condition:   Breast Cancer
Interventions:   Drug: cisplatin;   Drug: gemcitabine hydrochloride
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed - verified July 2016

Refine Your Search Advanced Search