Underactive Thyroid

Clinical Trials for Underactive Thyroid Gland (Hypothyroidism)

Clinical Trials for Underactive Thyroid Gland (Hypothyroidism)

General purpose

Research related to thyroid gland activity may investigate the role that genetics has in the development of the condition – in particular for children – as well as why women are more often affected than men.

In addition, some research may focus on certain viral or bacterial exposures that trigger the body’s immune system to attack the thyroid gland.

Research may also seek to better understand the role that pregnancy has in causing hypothyroidism, as well as the possible relationship between hypothyroidism and infertility.

Underactive Thyroid Clinical Trials Continued (Click to Open)

Clinical Trials for Underactive Thyroid Gland (Hypothyroidism)

Underactive Thyroid Gland

What do clinical trials for Hypothyroidism involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for hypothyroidism:

  • Blood tests to measure
    • Levels of the hormones TSH and thyroxine
    • Cholesterol
    • Genetic factors
    • Complete blood count
    • Liver enzymes
    • Prolactin levels
    • Sodium
  • Chest x-ray to examine heart
  • Assessments of how hypothyroidism affecting the patient’s quality of life.

Examples of Hypothyroidism- related research topics:

  • Studies comparing new diagnostic methods for detecting hypothyroidism to determine which one is the most sensitive and accurate.
  • Studies designed to determine the risk of heart failure and other cardiovascular disease among patients with hypothyroidism.
  • Studies that investigate lifestyle changes to help patients with hypothyroidism better manage their symptoms (such as fatigue, weight gain, cold intolerance, and depression).
  • Studies that investigate the reason why individuals with other autoimmune diseases (such as type 1 diabetes, rheumatoid arthritis, or lupus) are at an increased risk of developing hypothyroidism.
  • Studies investigating new drugs that can treat rheumatoid arthritis with fewer side effects than conventional treatments.

Suggested search terms for best results: 

“Underactive Thyroid Gland ““underactive thyroid [or hypothyroidism] pregnancy,” “underactive thyroid [or hypothyroidism] congenital,” “underactive thyroid [or hypothyroidism] treatment,” “underactive thyroid [or hypothyroidism] heart,” and “underactive thyroid [or hypothyroidism] depression.” 



Effect of Age, Weight and Sex on Levothyroxine Pharmacokinetics


Condition:   Hypothyroidism Primary
Intervention:   Drug: Administration of stable Isotope labeled levothyroxine
Sponsor:   Georgetown University
Completed - verified March 2017


Interaction Between Levothyroxine and Probiotics in Hypothyroid Patients


Condition:   Hypothyroidism
Interventions:   Other: a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®);   Drug: levothyroxin
Sponsor:   Azienda USL Modena
Completed - verified March 2017


The Prevalence of Sub Clinical Hypothyroidism During Early Pregnancy in Pakistan


Condition:   Subclinical Hypothyroidism
Intervention:  
Sponsors:   Abbott;   Dimension Research
Recruiting - verified January 2017


Hypothyroidism, Metabolism and Food Intake


Condition:   Hypothyroidism
Intervention:   Drug: Levothyroxine
Sponsors:   Herlev Hospital;   Center for Diabetes Research, Herlev and Gentofte Hospital.
Recruiting - verified December 2016


Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States


Condition:   Hypothyroidism
Intervention:   Drug: Iodinated contrast agents
Sponsor:   Bayer
Recruiting - verified May 2017


Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism


Condition:   Hypothyroidism
Interventions:   Drug: L-Thyroxine (tablet, per os);   Drug: L-Thyroxine (oral drops, solution)
Sponsor:   Meyer Children's Hospital
Recruiting - verified September 2016


Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition


Condition:   Hypothyroidism
Intervention:   Drug: Levothyroxine treatment
Sponsor:   Herlev Hospital
Recruiting - verified September 2016


Observational Study on Hypothyroidism in Young Children Following Iodine Contrast Exposure


Condition:   Hypothyroidism
Intervention:   Drug: iodinated contrast agents
Sponsor:   Bayer
Completed - verified October 2016


Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?


Conditions:   Postsurgical Hypothyroidism;   Hypothyroidism
Interventions:   Procedure: thyroidectomy;   Drug: levothyroxine in thyroidectomy patients
Sponsors:   University of Colorado, Denver;   Charite University, Berlin, Germany
Recruiting - verified November 2016


Mean Percentage of Levothyroxine Dosage Increase in Patients With Hypothyroidism Started on Enteral Feeding


Condition:   Hypothyroidism
Intervention:   Drug: Levothyroxine
Sponsors:   Jocelyne Karam;   Maimonides Medical Center
Recruiting - verified June 2016


Effect of Levothyroxine on Serum Adiponectin, Insulin Resistance and Cardiovascular Risk in Patients With Hypothyroidism


Condition:   Hypothyroidism
Intervention:   Drug: Levothyroxine
Sponsor:   All India Institute of Medical Sciences, Bhubaneswar
Recruiting - verified May 2017


Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism


Condition:   Congenital Hypothyroidism
Interventions:   Drug: Levothyroxine;   Device: Ultrasound
Sponsor:   Erica Eugster
Completed - verified March 2017


Effect of Hypothyroidism on Brown Adipose Tissue


Condition:   Hypothyroidism
Intervention:  
Sponsor:   University Hospital, Basel, Switzerland
Active, not recruiting - verified April 2017


Evaluation of Hypothyroidism Incidence After Breast Cancer Supraclavicular Irradiation


Conditions:   Irradiation; Adverse Effect;   Irradiation Hypothyroidism
Interventions:   Biological: biological sample;   Radiation: supraclavicular irradiation
Sponsor:   Institut Jean-Godinot
Active, not recruiting - verified June 2016


Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism


Condition:   Subclinical hypothyroïdism
Intervention:   Drug: LEVOTHYROXINE
Sponsor:   Centre Hospitalier Universitaire de Nice
Withdrawn - verified October 2016


Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism


Conditions:   Hyperthyroidism;   Hypothyroidism
Intervention:  
Sponsor:   Steen Bonnema
Recruiting - verified June 2016


Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.


Condition:   Congenital Hypothyroidism
Intervention:   Other: Clinical and radiologic exams and blood samples
Sponsor:   Assistance Publique - Hôpitaux de Paris
Active, not recruiting - verified August 2016


The TRUST Study - Depression Substudy


Conditions:   Subclinical Hypothyroidism;   Depression
Interventions:   Drug: Levothyroxine;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   Leiden University Medical Center;   University of Bern
Recruiting - verified October 2016


Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism


Conditions:   Hypothyroidism;   Thyroid Diseases;   Endocrine System Diseases
Intervention:   Drug: L-thyroxine
Sponsor:   Shandong Provincial Hospital
Active, not recruiting - verified April 2017


Treatment Trial of Subclinical Hypothyroidism in Down Syndrome


Conditions:   Down Syndrome;   Subclinical Hypothyroidism
Intervention:   Drug: Levothyroxine
Sponsors:   Children's Hospital of Philadelphia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2016


Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism


Conditions:   Hypothyroidism;   Thyroid Diseases;   Endocrine System Diseases
Intervention:   Drug: L-thyroxine
Sponsor:   Shandong Provincial Hospital
Active, not recruiting - verified June 2016


Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism


Conditions:   Hypothyroidism;   Thyroidectomy
Intervention:  
Sponsors:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   National Heart, Lung, and Blood Institute (NHLBI)
Withdrawn - verified November 29, 2013


Thyroid Hormone Replacement for Subclinical Hypothyroidism


Condition:   Subclinical Hypothyroidism
Interventions:   Drug: Levothyroxine;   Drug: Placebo
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow;   University College Cork;   University of Bern;   Leiden University Medical Center
Completed - verified March 2017


Lipids Profile in Subclinical Hypothyroidism


Condition:   Subclinical Hypothyroidism
Intervention:   Procedure: laboratory analysis
Sponsors:   HaEmek Medical Center, Israel;   University of Palermo;   University of Zurich
Terminated - verified September 2016


Thyroid Hormone Dose Adjustment in Pregnancy


Conditions:   Pregnancy;   Hypothyroidism
Interventions:   Drug: Anticipatory dose increase of levothyroxine;   Drug: levothyroxine;   Drug: levothyroxine
Sponsors:   Brigham and Women's Hospital;   Harvard Medical School
Completed - verified October 2016

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