Type 1 Diabetes

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Diabetes (Type 1) Clinical Trials

General purpose: Research related to type 1 diabetes may investigate new methods for diagnosing diabetes, ways to refine the diagnostic accuracy of existing test methods, improved treatment options (such as different insulin delivery methods or newly developed oral medications designed to control blood glucose levels), and behavioral / lifestyle factors that can aid in the management of type 1 diabetes.

In addition, research may also look at possible genetic factors that might make a person more likely to develop type 1 diabetes.

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Diabetes (Type 1) Clinical Trials

Type 1 Diabetes Clinical Trials

What do typical clinical trials for Type 1 Diabetes involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for Type 1 Diabetes:

  • Fasting blood glucose levels.
  • Random blood glucose levels.
  • Oral glucose tolerance tests, which involves drinking a sweet drink with a known amount of glucose and then having blood drawn at regular intervals over a specified period of time (usually several hours).
  • Hemoglobin A1c test, which measures an individual’s average blood glucose level over a two to three month period.
  • Urine sample or blood sample to measure ketone levels (ketones are produced when the body burns fat for energy rather than glucose).
  • Monitoring of body weight.
  • Monitoring of cholesterol and triglyceride levels, blood pressure, kidney function, and nerve function.
  • Visual inspection of the skin and bones on feet and legs.
  • Food intake monitoring using food diaries or computer-based tracking systems.

Examples of Type 1 Diabetes-related research topics:

  • Immune therapy for the prevention and treatment of diabetes.
  • New therapies designed to improve glucose control.
  • New therapies designed to treat the complications associated with diabetes, such as nerve pain, vision loss, and kidney damage.
  • Research designed to develop vaccines against the factors that trigger the immune system to attack the pancreas.
  • Development of new therapies to stop or reverse the immune system’s attack on the pancreas, thereby removing the need for insulin therapy.

Suggested search terms for best results:  “obesity and diabetes,” “children and diabetes,” “insulin and diabetes,” “diabetes prevention,” “diabetes treatment.”



Impact of the Continuous Measurement of Blood Glucose on Insulin Pump on Child Quality of Life With Type 1 Diabetes


Condition:   Type1diabetes
Interventions:   Behavioral: Peds QL questionnaire and diabetes modulate;   Behavioral: WHO-5 questionnaire;   Behavioral: Felt questionnaire
Sponsor:   Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Active, not recruiting


Group Education Curriculum for Older Teens With Type 1 Diabetes


Condition:   Type 1 Diabetes Mellitus
Intervention:   Behavioral: Intervention
Sponsor:   Boston Children’s Hospital
Recruiting


Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Ergocalciferol;   Other: Placebo
Sponsor:   University of Massachusetts, Worcester
Recruiting


Use of Continuous Glucose Monitoring System With Intensive Feedback in Adolescents With Poorly Controlled Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Device: CGMS Device;   Other: No Device
Sponsor:   New York University School of Medicine
Enrolling by invitation


Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents


Condition:   Type1diabetes
Intervention:   Other: Blood sampling
Sponsors:   Hasselt University;   Jessa Hospital
Completed


Study the Feasibility of Permanent Use of inControl for the Treatment of Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Device: insulin pump to inControl AP platform
Sponsors:   University Hospital, Montpellier;   MEDBIOMED, Montpellier, France;   Jaeb Center for Health Research;   University of Virginia
Recruiting


Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Procedure: Islet graft;   Drug: best medical care
Sponsor:   University Hospital, Grenoble
Recruiting


Gene-virus Interactions Implicated in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Genetic: Enterovirus vaccination
Sponsor:   Hospices Civils de Lyon
Not yet recruiting


Modulation of STAT3 Signaling With Siltuximab in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Drug: Siltuximab
Sponsors:   Carla Greembaum, MD;   Janssen Research & Development, LLC
Active, not recruiting


Impact of a Diabetes Camp on Glycemic Control Among Children and Adolescents Living With Type 1 Diabetes in Cameroon


Condition:   Type 1 Diabetes
Intervention:   Drug: Insulin
Sponsor:   Yaounde Central Hospital
Completed


The Safety and Efficacy of Dapagliflozin Therapy in Combination With Insulin in Japanese Subjects With Type 1 Diabetes Mellitus (T1DM)


Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: Dapagliflozin 5 mg;   Drug: Dapagliflozin 10mg
Sponsor:   AstraZeneca
Completed


Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus


Condition:   Type 1 Diabetes Mellitus
Interventions:   Drug: Pramlintide acetate;   Drug: Placebo;   Drug: Lispro insulin U-100;   Drug: Regular insulin U-100
Sponsors:   AstraZeneca;   Juvenile Diabetes Research Foundation
Completed


Pancreas Volume in Preclinical Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Procedure: MRI, US, and blood samples
Sponsors:   University of Florida;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


Tauroursodeoxycholic Acid (TUDCA) in New-Onset Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Tauroursodeoxycholic Acid (TUDCA);   Drug: Sugar Pill (placebo)
Sponsors:   Robin Goland, MD;   Juvenile Diabetes Research Foundation
Recruiting


Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2


Condition:   Type 1 Diabetes
Intervention:   Drug: Aldesleukin (Proleukin)
Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   University of Cambridge;   Juvenile Diabetes Research Foundation;   National Institute for Health Research, United Kingdom;   Wellcome Trust
Completed


52 Week Trial of Liraglutide in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Drug: Liraglutide
Sponsors:   CHU de Quebec-Universite Laval;   Novo Nordisk A/S
Unknown status


Open-label Investigation of the Safety and Effectiveness of DIABECELL® in Patients With Type 1 Diabetes Mellitus


Condition:   Type 1 Diabetes
Intervention:   Device: DIABECELL (R)
Sponsor:   Diatranz Otsuka Limited
Completed


Islet Allotransplantation in Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Drug: Human Pancreatic Islets
Sponsor:   Ohio State University
Enrolling by invitation


Imaging of Type 1 Diabetes Progression


Condition:   Type 1 Diabetes
Intervention:   Drug: ferumoxytol
Sponsors:   Jason Gaglia;   National Institute of Allergy and Infectious Diseases (NIAID);   Harvard Medical School
Active, not recruiting


Diabetes Care Management Compared to Standard Diabetes Care in Adolescents and Young Adults With Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Other: Transition Coordinator
Sponsors:   University of Western Ontario, Canada;   Juvenile Diabetes Research Foundation
Active, not recruiting


Efficacy and Safety Study of Autologous Hematopoietic Stem Cell Transplantation to Treat New Onset Type 1 Diabetes


Condition:   Type 1 Diabetes
Intervention:   Procedure: immunosuppression and stem cell transplantation
Sponsor:   The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Completed


New Onset Type 1 Diabetes: Role of Exenatide


Condition:   Type 1 Diabetes
Interventions:   Drug: Exenatide;   Drug: Rapid and long acting insulin;   Drug: long acting insulin + rapid acting + 1.25 mcg Exenatide
Sponsors:   Albert Einstein College of Medicine, Inc.;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting


Assessing Glucose Effects of Sitagliptin (Januvia) in Adult Patients With Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Drug: Sitagliptin;   Drug: Sugar Pill
Sponsor:   University of Colorado Denver School of Medicine Barbara Davis Center
Completed


Neurocognitive Impact of Hypoglycemia in Type 1 Diabetes


Condition:   Type 1 Diabetes Mellitis
Intervention:  
Sponsors:   Washington University School of Medicine;   National Institutes of Health (NIH)
Active, not recruiting


Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes


Condition:   Type 1 Diabetes
Interventions:   Device: Closed loop;   Device: Home glucose monitoring;   Device: Insulin pump;   Device: Continuous glucose monitor
Sponsor:   Jaeb Center for Health Research
Terminated

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