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Lupus (SLE)

Clinical Trials for Lupus

Clinical Trials for Lupus

Clinical Trials for Lupus

General purpose: Research may investigate a variety of potential topics, including: potential causes of lupus, factors that may prevent the onset of lupus, genetic mutations associated with an increased risk of developing lupus.

The role of the body’s immune system in the development of lupus, environmental factors that may cause lupus or exacerbate its symptoms. The gender differences associated with the risk and severity of lupus, new treatments, and ways to prevent lupus from attacking various body systems and organs (such as the central nervous system, kidneys, and skin).

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SLE Clinical Trials

What do typical clinical trials for Lupus involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials. However, below is a list of common procedures and data that are frequently collected during a trial for lupus:

  • Detailed personal information related to prior environmental, chemical, and biologic exposures.
  • Prior history of various diseases, such as rheumatoid arthritis, chronic fatigue syndrome, fibromyalgia, and others.
  • Blood tests to measure:
    • Antibodies, including antinuclear antibodies (ANA) panel, antithyroglobulin antibody, antithyroid microsomal antibody, complement component antibodies C3 and C4, cryoglobulins, erythrocyte sedimentation rate (ESR, or “sed rate”)
    • Complete blood count (CBC)
    • Rheumatoid factor
  • Chest x-ray
  • Kidney biopsy
  • Urine tests
  • Kidney function tests
  • Liver function tests

Examples of Lupus-related research topics:

Improved understanding of how and why lupus develops by comparing the personal histories and exposures of patients with lupus. These may include:

  • Studies to assess potential genetic influences.
  • Studies to assess environmental influences (chemical, occupational).
  • Studies to evaluate biologic factors (bacterial or viral infections; individual immune system characteristics).
  • Studies to determine new and effective medications to treat lupus.
  • Studies to observe the long-term effects of lupus on the body and mind, using imaging tests, mental health evaluations, and observation.

Suggested search terms related to Systemic Lupus Erythematosus:

“systemic lupus erythematosus treatment,” “systemic lupus erythematosus prevention,” “systemic lupus erythematosus diagnosis,” “pediatric systemic lupus erythematosus,” “systemic lupus erythematosus organ damage,” and “systemic lupus erythematosus autoimmune.”