Join Clinical Trials for Scleroderma

General purpose:  Clinical trials for Scleroderma may study the role of the immune system in its development, alternative therapies for its treatments, and how it impacts the skin, blood vessels, muscles, and internal organs.

Scleroderma research also seeks to discover the cause of the condition, its relationship to other autoimmune diseases (such as rheumatoid arthritis and lupus), as well as why it occurs most often in women.

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Clinical Trials for Rheumatoid Arthritis

What do clinical trials for Scleroderma involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for scleroderma:

  • Physical exam to evaluate the condition of the skin.
  • Blood pressure checks (as scleroderma can cause inflammation in the blood vessels of the kidneys and other organs).
  • Blood tests such as the following:
  • Antinuclear antibody (ANA) panel
  • Antibody testing
  • ESR / sed rate
  • Rheumatoid factor
    • Chest x-ray
    • Computed tomography (CT) scan of the lungs
    • Echocardiogram (EKG)
    • Urine tests
    • Lung function tests
    • Skin biopsies

Examples of scleroderma- related research topics:

  • Studies investigating new treatments for the symptoms associated with scleroderma.
  • Studies investigating the use of a pregnancy-related hormone called relaxin to soften connective tissues in women with scleroderma.
  • Studies designed to evaluate common genetic factors among individuals with scleroderma in order to identify genetic mutations associated with an increased risk of developing the condition.
  • Investigating the effectiveness of new drugs to treat the lung symptoms associated with scleroderma.
  • Investigating the effectiveness of drugs to treat and prevent kidney failure in patients with scleroderma.
  • Studies investigating the role of malfunctioning blood vessels, cellular death, and autoimmune system dysfunction in scleroderma.

Suggested search terms for best results: 

Scleroderma” “scleroderma kidneys” “scleroderma lungs,” “scleroderma treatment,” “scleroderma skin,” “scleroderma blood pressure,” and “scleroderma hormones.”

Gut Microbiota Transplantation in Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Biological: Anaerobically Cultivated Human Intestinal Microbiota;   Biological: Anaerobically Cultivated medium
Sponsor:   Oslo University Hospital
Active, not recruiting

Scleroderma Patient-centered Intervention Network (SPIN) Hand Program

Conditions:   Scleroderma;   Systemic Sclerosis
Intervention:   Other: SPIN-HAND Program
Sponsors:   Lady Davis Institute;   Canadian Institutes of Health Research (CIHR);   The Arthritis Society, Canada

Efficacy and Safety of PLACENTEX ® i.m. in Patients With Scleroderma Diseases

Condition:   Scleroderma Disease
Intervention:   Drug: Polydeoxyribonucleotides
Sponsors:   Mastelli S.r.l;   Sintesi Research Srl

Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc)

Conditions:   Systemic Sclerosis;   Scleroderma
Interventions:   Drug: Tofacitinib;   Drug: Placebo Oral Tablet
Sponsors:   University of Michigan;   Pfizer

MRI Quantification of Pulmonary Fibrosis in Scleroderma Patients

Condition:   Scleroderma
Intervention:   Other: unenhanced MR sequences
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Centrale Supelec School (Center for Visual Computing)

The Effect of Ethanol Extract Physalis Angulata Linn. in Scleroderma Patients With Standard Therapy

Condition:   Scleroderma
Interventions:   Other: Physalis angulata ethanol extract;   Other: Placebo
Sponsors:   Indonesia University;   Netherlands: Ministry of Health, Welfare and Sports

Scleroderma Patient-centered Intervention Network (SPIN) Hand Program Feasibility Study

Conditions:   Scleroderma;   Systemic Sclerosis
Intervention:   Other: SPIN-HAND program
Sponsors:   Lady Davis Institute;   Hôpital Cochin

Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: GSK2330811;   Drug: Placebo
Sponsor:   GlaxoSmithKline

Riociguat in Scleroderma Associated Digital Ulcers

Conditions:   Scleroderma;   Digital Ulcers
Interventions:   Drug: Riociguat;   Drug: Placebo
Sponsors:   Dinesh Khanna, MD, MS;   Bayer

The Scleroderma Biorepository and Pathogenesis Study (STOP Scleroderma)

Condition:   Scleroderma
Sponsor:   George Washington University

Duke Scleroderma Clinic Patient Registry

Conditions:   Scleroderma;   Systemic Sclerosis
Intervention:   Other: Registry
Sponsor:   Duke University

Novel Rehabilitation Strategies to Improve Arm Function in Patients With Scleroderma

Conditions:   Scleroderma;   Ssc
Intervention:   Other: Occupational therapy treatment
Sponsors:   University of Michigan;   University of Alabama at Birmingham

A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis

Condition:   Scleroderma, Systemic
Interventions:   Drug: Nintedanib;   Drug: Placebo
Sponsor:   Boehringer Ingelheim
Active, not recruiting

Taking Charge of Systemic Sclerosis

Condition:   Scleroderma
Interventions:   Other: Internet-based self-management program;   Other: Scleroderma book
Sponsors:   University of Michigan;   University of New Mexico;   Medical University of South Carolina;   Patient-Centered Outcomes Research Institute
Active, not recruiting

Safety & Suitability of Dabigatran to Inhibit Thrombin in Scleroderma

Conditions:   Scleroderma;   Interstitial Lung Disease
Intervention:   Drug: dabigatran etexilate
Sponsors:   Medical University of South Carolina;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma

Condition:   Scleroderma
Interventions:   Drug: atorvastatin;   Drug: Placebo
Sponsors:   Robyn T. Domsic, MD, MPH;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Trial of Topical C-82 in Systemic Sclerosis - A Phase I/II Biomarker and Safety Trial

Condition:   Systemic Scleroderma
Interventions:   Drug: C-82 Topical Gel, 1%;   Drug: C-82 Topical Gel, Placebo
Sponsor:   Prism Pharma Co., Ltd.

Calcinosis in a Single-Center Scleroderma Population

Conditions:   Scleroderma;   Calcinosis
Sponsor:   Rutgers, The State University of New Jersey

IVIG Treatment in Systemic Sclerosis

Conditions:   Systemic Sclerosis;   Diffuse Scleroderma
Intervention:   Biological: Privigen
Sponsors:   Georgetown University;   CSL Behring

Scleroderma Registry & Repository at the Hospital for Special Surgery

Condition:   Scleroderma
Sponsor:   Hospital for Special Surgery, New York

Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis

Condition:   Scleroderma
Intervention:   Drug: Campath
Sponsor:   Children's Hospital Los Angeles

Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial

Condition:   Scleroderma
Interventions:   Procedure: Cytoxan rATG/Fludarabine/HSCT;   Procedure: Cytoxan rATG/HSCT
Sponsor:   Northwestern University

Scleroderma Treatment With Autologous Transplant (STAT) Study

Condition:   Systemic Scleroderma
Interventions:   Biological: Anti-Thymocyte Globulin;   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Cyclophosphamide;   Biological: Filgrastim;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Procedure: Peripheral Blood Stem Cell Transplantation;   Drug: Plerixafor;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI)

High Dose Cyclophosphamide for Treatment of Scleroderma

Condition:   Scleroderma
Intervention:   Drug: IV Cyclophosphamide
Sponsor:   Johns Hopkins University

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