Rheumatoid Arthritis

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Clinical Trials for Rheumatoid ArthritisGeneral purpose: 

Clinical trials for rheumatoid arthritis may study the role of the immune system in its development, alternative therapies for rheumatoid arthritis, how rheumatoid arthritis affects the body as a whole, as well as the role of genetics and hormone in the development of rheumatoid arthritis.

Research may also test new drug therapies for rheumatoid arthritis, and compare their effectiveness to existing drug therapies or alternative medicine therapies, such as herbal supplements, acupuncture, and dietary modifications.

What do clinical trials for Rheumatoid Arthritis involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for rheumatoid arthritis:

  • Blood tests to measure levels of certain immune system markers (such as rheumatoid factor and anti-CCP antibodies) or genetic factors.
  • Blood tests to measure:
    • Complete blood count
    • C-reactive protein
    • ESR / sed rate
  • Ultrasound and/or MRI
  • X-rays of the joints
  • Biopsy and analysis of joint fluid (i.e., “synovial fluid”).
  • Assessments of how rheumatoid arthritis is affecting the patient’s quality of life.

Examples of Rheumatoid Arthritis- related research topics:

  • Studies looking at the immune systems of individuals who have rheumatoid arthritis in order to understand how and why it develops.
  • Studies of genetic factors in families with multiple cases of rheumatoid arthritis, in order to understand how genetics increases the risk of developing rheumatoid arthritis.
  • Studies comparing the clinical, imaging (e.g., X-ray), DNA data of rheumatoid arthritis from specific racial and ethnic groups in order to understand how the disease course differs between those groups.
  • Studies investigating the interaction between hormones, nerves, and the immune system in rheumatoid arthritis patients.
  • Studies investigating the increased risk of rheumatoid arthritis among women, as well as why rheumatoid arthritis often improves during pregnancy.
  • Studies investigating new drugs that can treat rheumatoid arthritis with fewer side effects than conventional treatments.

Suggested search terms for “rheumatoid arthritis:

“Rheumatoid Arthritis” “rheumatoid arthritis treatment,” “juvenile rheumatoid arthritis,” “rheumatoid arthritis methotrexate,” “rheumatoid arthritis pregnancy,” “rheumatoid arthritis complications,” and “rheumatoid arthritis symptoms.”



Validation of the French Version of the Health Assessment Questionnaire II (HAQ-II) for Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   Rennes University Hospital
Completed


Anxiety Depression and Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:   Other: Anxiety or depression
Sponsor:   Sichuan Provincial People's Hospital
Not yet recruiting


The Effects of Hyperbaric Oxygen on Rheumatoid Arthritis


Condition:   RheumatoId Arthritis
Intervention:   Device: Hyperbaric Oxygen
Sponsor:   David Grant U.S. Air Force Medical Center
Enrolling by invitation


A Phase 2 Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to Biologics


Condition:   Rheumatoid Arthritis
Interventions:   Drug: E6011;   Drug: Placebo
Sponsor:   Eisai Co., Ltd.
Recruiting


A Dose Response Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to Methotrexate


Condition:   Rheumatoid Arthritis
Interventions:   Drug: E6011;   Drug: Placebo
Sponsor:   Eisai Co., Ltd.
Recruiting


Rheumatoid Arthritis Patients and Porphyromonas Gingivalis


Condition:   Rheumatoid Arthritis
Interventions:   Procedure: blood sample;   Procedure: synovial tissue
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Recruiting


Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of VAY736 in Rheumatoid Arthritis Patients


Condition:   Rheumatoid Arthritis
Interventions:   Biological: VAY736;   Biological: VAY736 placebo
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting


Oral Metagenomic Biomarkers in Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Procedure: Dental Plaque;   Other: Multi-dimensional health assessment questionnaire (MDHAQ);   Other: Saliva Collection
Sponsors:   University of Florida;   United States Department of Defense;   VA Medical Center-Gainesville
Recruiting


Pragmatic Study Comparing the Clinical Evlauation Methods ( C) and / or Ultrasound Method ( B or D) in Rheumatoid Arthritis to Adapt Treatment


Condition:   Rheumatoid Arthritis
Interventions:   Device: Xrays;   Device: Ultrasound (B mode );   Device: Ultrasound (D mode)
Sponsor:   University Hospital, Brest
Recruiting


Reduced Ultrasound Counts in Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsors:   Hospital General Universitario Gregorio Marañon;   Roche Pharma AG
Recruiting


Incorporation of Patient Reported Outcomes Data in the Care of US Veterans With Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Other: PRO data utilized;   Other: PRO data not utilized
Sponsors:   North Florida Foundation for Research and Education;   Pfizer;   VA Office of Research and Development
Active, not recruiting


A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs


Condition:   Rheumatoid Arthritis
Interventions:   Drug: peficitinib;   Drug: Placebo;   Biological: Etanercept
Sponsor:   Astellas Pharma Inc
Active, not recruiting


A Study Comparing SB5 to Humira® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy


Condition:   Rheumatoid Arthritis
Interventions:   Drug: Humira (adalimumab);   Drug: SB5 (proposed biosimilar to adalimumab)
Sponsor:   Samsung Bioepis Co., Ltd.
Completed


Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients


Condition:   Rheumatoid Arthritis
Interventions:   Biological: CFZ533;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Completed


The PRESS RA: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Dietary Supplement: Protein;   Dietary Supplement: Carbohydrate (Placebo);   Other: Resistance Exercise Program
Sponsors:   Johns Hopkins University;   National Institute on Aging (NIA);   American College of Rheumatology Research and Education Foundation
Suspended


Discovering the Antecedents of Rheumatoid Arthritis Flare


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   Rockefeller University
Recruiting


ACTH Gel Therapy in Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:   Drug: ACTHAR gel
Sponsors:   Dr. Larry W. Moreland;   Mallinckrodt
Recruiting


Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:   Other: Braquial ecography
Sponsors:   Hospital Universitario de Canarias;   Roche Pharma AG
Active, not recruiting


Special Investigation in Patients With Rheumatoid Arthritis (Combo Study; Adalimumab With High Dose Methotrexate)


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   AbbVie (prior sponsor, Abbott)
Active, not recruiting


Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Biological: Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs);   Drug: Rheumatoid Arthritis With Disease-Modifying Drugs (DMARDs);   Biological: UC-MSC+DMARDS
Sponsor:   Alliancells Bioscience Corporation Limited
Unknown status


Special Investigation in Patients With Rheumatoid Arthritis (Working Productivity Activity Impairment)


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   AbbVie (prior sponsor, Abbott)
Completed


The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)


Condition:   Rheumatoid Arthritis
Interventions:   Biological: apremilast;   Other: Placebo
Sponsor:   Baylor Research Institute
Completed


Sleep and Immunity in Rheumatoid Arthritis : Remicade Substudy


Condition:   Rheumatoid Arthritis
Intervention:   Drug: Remicade
Sponsors:   University of California, Los Angeles;   National Heart, Lung, and Blood Institute (NHLBI)
Completed


Prospective Study on Intensive Early Rheumatoid Arthritis Treatment


Condition:   Rheumatoid Arthritis
Interventions:   Drug: adalimumab, plus prednisone;   Drug: adalimumab plus placebo
Sponsor:   IRCCS Policlinico S. Matteo
Completed


A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis.


Condition:   Rheumatoid Arthritis
Interventions:   Drug: Imatinib;   Drug: Methotrexate;   Drug: Imatinib Placebo
Sponsor:   Novartis Pharmaceuticals
Completed

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