Rheumatoid Arthritis

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Clinical Trials for Rheumatoid ArthritisGeneral purpose: 

Clinical trials for rheumatoid arthritis may study the role of the immune system in its development, alternative therapies for rheumatoid arthritis, how rheumatoid arthritis affects the body as a whole, as well as the role of genetics and hormone in the development of rheumatoid arthritis.

Research may also test new drug therapies for rheumatoid arthritis, and compare their effectiveness to existing drug therapies or alternative medicine therapies, such as herbal supplements, acupuncture, and dietary modifications.

What do clinical trials for Rheumatoid Arthritis involve?

Clinical trials will vary widely in the information they collect, as well as the tests and procedures they use. All of these factors will depend on individual study designs, which will differ greatly between trials.

However, below is a list of common procedures and data that are frequently collected during a trial for rheumatoid arthritis:

  • Blood tests to measure levels of certain immune system markers (such as rheumatoid factor and anti-CCP antibodies) or genetic factors.
  • Blood tests to measure:
    • Complete blood count
    • C-reactive protein
    • ESR / sed rate
  • Ultrasound and/or MRI
  • X-rays of the joints
  • Biopsy and analysis of joint fluid (i.e., “synovial fluid”).
  • Assessments of how rheumatoid arthritis is affecting the patient’s quality of life.

Examples of Rheumatoid Arthritis- related research topics:

  • Studies looking at the immune systems of individuals who have rheumatoid arthritis in order to understand how and why it develops.
  • Studies of genetic factors in families with multiple cases of rheumatoid arthritis, in order to understand how genetics increases the risk of developing rheumatoid arthritis.
  • Studies comparing the clinical, imaging (e.g., X-ray), DNA data of rheumatoid arthritis from specific racial and ethnic groups in order to understand how the disease course differs between those groups.
  • Studies investigating the interaction between hormones, nerves, and the immune system in rheumatoid arthritis patients.
  • Studies investigating the increased risk of rheumatoid arthritis among women, as well as why rheumatoid arthritis often improves during pregnancy.
  • Studies investigating new drugs that can treat rheumatoid arthritis with fewer side effects than conventional treatments.

Suggested search terms for “rheumatoid arthritis:

“Rheumatoid Arthritis” “rheumatoid arthritis treatment,” “juvenile rheumatoid arthritis,” “rheumatoid arthritis methotrexate,” “rheumatoid arthritis pregnancy,” “rheumatoid arthritis complications,” and “rheumatoid arthritis symptoms.”



Anxiety Depression and Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:   Other: Anxiety or depression
Sponsor:   Sichuan Provincial People's Hospital
Not yet recruiting - verified April 2017


The Effects of Hyperbaric Oxygen on Rheumatoid Arthritis


Condition:   RheumatoId Arthritis
Intervention:   Device: Hyperbaric Oxygen
Sponsor:   David Grant U.S. Air Force Medical Center
Enrolling by invitation - verified December 2016


A Phase 2 Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to Biologics


Condition:   Rheumatoid Arthritis
Interventions:   Drug: E6011;   Drug: Placebo
Sponsor:   Eisai Co., Ltd.
Recruiting - verified March 2017


A Dose Response Study of E6011 in Subjects With Rheumatoid Arthritis Inadequately Responding to Methotrexate


Condition:   Rheumatoid Arthritis
Interventions:   Drug: E6011;   Drug: Placebo
Sponsor:   Eisai Co., Ltd.
Recruiting - verified March 2017


Rheumatoid Arthritis Patients and Porphyromonas Gingivalis


Condition:   Rheumatoid Arthritis
Interventions:   Procedure: blood sample;   Procedure: synovial tissue
Sponsor:   Centre Hospitalier Universitaire de Saint Etienne
Recruiting - verified January 2017


Oral Metagenomic Biomarkers in Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Procedure: Dental Plaque;   Other: Multi-dimensional health assessment questionnaire (MDHAQ);   Other: Saliva Collection
Sponsors:   University of Florida;   United States Department of Defense;   VA Medical Center-Gainesville
Recruiting - verified February 2017


Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of VAY736 in Rheumatoid Arthritis Patients


Condition:   Rheumatoid Arthritis
Interventions:   Biological: VAY736;   Biological: VAY736 placebo
Sponsor:   Novartis Pharmaceuticals
Active, not recruiting - verified April 2017


Pragmatic Study Comparing the Clinical Evlauation Methods ( C) and / or Ultrasound Method ( B or D) in Rheumatoid Arthritis to Adapt Treatment


Condition:   Rheumatoid Arthritis
Interventions:   Device: Xrays;   Device: Ultrasound (B mode );   Device: Ultrasound (D mode)
Sponsor:   University Hospital, Brest
Recruiting - verified January 2017


Reduced Ultrasound Counts in Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsors:   Hospital General Universitario Gregorio Marañon;   Roche Pharma AG
Recruiting - verified April 2017


Incorporation of Patient Reported Outcomes Data in the Care of US Veterans With Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Other: PRO data utilized;   Other: PRO data not utilized
Sponsors:   North Florida Foundation for Research and Education;   Pfizer;   VA Office of Research and Development
Active, not recruiting - verified March 2017


A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs


Condition:   Rheumatoid Arthritis
Interventions:   Drug: ASP015K;   Drug: Placebo;   Biological: Etanercept
Sponsor:   Astellas Pharma Inc
Active, not recruiting - verified January 2017


A Study to Evaluate Efficacy and Safety of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to Methotrexate (MTX) Treatment


Condition:   Rheumatoid Arthritis
Interventions:   Drug: ASP015K;   Drug: Placebo
Sponsor:   Astellas Pharma Inc
Active, not recruiting - verified April 2017


A Study Comparing SB5 to Humira® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy


Condition:   Rheumatoid Arthritis
Interventions:   Drug: Humira (adalimumab);   Drug: SB5 (proposed biosimilar to adalimumab)
Sponsor:   Samsung Bioepis Co., Ltd.
Completed - verified November 2016


Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose CFZ533 in Rheumatoid Arthritis Patients


Condition:   Rheumatoid Arthritis
Interventions:   Biological: CFZ533;   Drug: Placebo
Sponsor:   Novartis Pharmaceuticals
Completed - verified March 2017


Discovering the Antecedents of Rheumatoid Arthritis Flare


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   Rockefeller University
Recruiting - verified October 2016


The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients


Condition:   Rheumatoid Arthritis
Intervention:   Drug: corticotrophin 80 units
Sponsor:   Gaylis, Norman B., M.D.
Active, not recruiting - verified August 2016



Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Intervention:   Other: Braquial ecography
Sponsors:   Hospital Universitario de Canarias;   Roche Pharma AG
Active, not recruiting - verified February 2017


Special Investigation in Patients With Rheumatoid Arthritis (Combo Study; Adalimumab With High Dose Methotrexate)


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   AbbVie (prior sponsor, Abbott)
Active, not recruiting - verified April 2017


Secukinumab Efficacy and Safety Study in Patients With Rheumatoid Arthritis and Inadequate Response to Anti-TNFα Agents.


Condition:   Rheumatoid Arthritis
Interventions:   Biological: Secukinumab (AIN457);   Biological: Placebo
Sponsor:   Novartis Pharmaceuticals
Terminated - verified June 2016


More Added Value of Therapeutic Education in the Management of Patients With Rheumatoid Arthritis (ETP-PR)


Condition:   Rheumatoid Arthritis
Interventions:   Other: immediate therapeutic education;   Other: therapeutic education delayed
Sponsor:   Nantes University Hospital
Terminated - verified August 2016


Special Investigation in Patients With Rheumatoid Arthritis (Working Productivity Activity Impairment)


Condition:   Rheumatoid Arthritis
Intervention:  
Sponsor:   AbbVie (prior sponsor, Abbott)
Completed - verified March 2017


Prospective Study on Intensive Early Rheumatoid Arthritis Treatment


Condition:   Rheumatoid Arthritis
Interventions:   Drug: adalimumab, plus prednisone;   Drug: adalimumab plus placebo
Sponsor:   IRCCS Policlinico S. Matteo
Completed - verified March 2017


Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis


Condition:   Rheumatoid Arthritis
Interventions:   Drug: Methoxsalen;   Procedure: Extracorporeal Photopheresis
Sponsor:   Mallinckrodt
Completed - verified October 2016


A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis.


Condition:   Rheumatoid Arthritis
Interventions:   Drug: Imatinib;   Drug: Methotrexate;   Drug: Imatinib Placebo
Sponsor:   Novartis Pharmaceuticals
Completed - verified April 2017

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