Food Allergies

Food Allergy Clinical TrialsFood Allergy Clinical Trials

General Purpose: Allergic symptoms arise when the immune system becomes over-sensitized (i.e., over-reactive) to a particular allergen or irritant. In the case of food allergies, an abnormal response of the body’s immune system to foods such as peanuts, shellfish, and milk can result in an allergic reaction.

Allergic reactions can vary from skin irritation to more serious complications including gastrointestinal disorders and anaphylaxis, which could also result in anaphylactic shock. The purpose of food allergy trials often examines the role of white blood cells in disease in order to determine how the immune system responds to a particular food allergy.

To prevent allergic reactions from food allergies, industries also run trials on large groups to determine the minimum eliciting dose of the allergic response.

Food Allergy Clinical Trials Continued … (Click to Open)

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What are Typical Food Allergy Clinical Trials Like?

Trial participants will undergo screening that involves a physical examination and medical history. In addition, blood samples will be collected to determine each individual’s sensitivity to the allergens being studied.

Additional tests may be performed to determine the participant’s level of sensitivity to particular foods, as well as stool sample testing for those participants who have eosinophil-associated gastrointestinal disorders.

Typical Trial Protocol for Food Allergy Clinical Trials:

Some studies seek to decrease the reaction of the immune system by gradually exposing individuals to small amounts of allergens over an extended period of time, in an effort to increase an individual’s tolerance.

This is known as immunotherapy. Immunotherapy trials can be lengthy, and may span over the course of several years. During these trials, individual participants’ tolerance to the allergen or allergens being studied will be assessed via blood tests at specified time points.

Other allergy-related trials may seek to determine the amount of exposure to a particular allergen that is required in order to elicit an allergic response. Trials such as this may also randomly assign some participants to receive a placebo, so that the results between the allergen and placebo group can be compared.

As a result, those in the placebo group would receive the same protocol procedures that the allergen group received, however they would not be exposed to the actual allergen being studied.

Suggested Search Terms

Food Allergies, Food Hypersensitivity, Peanut Hypersensitivity, Pediatric Diseases, Gastrointestinal Diseases.

Current Search Term: “Food Allergy”

Improvement of Foodallergy Diagnostic in Gastrointestinal Tract

Condition:   Food Allergy
Intervention:   Diagnostic Test: Cytobrush
Sponsor:   University of Erlangen-Nürnberg Medical School
Recruiting - verified May 2017

Basophile Activation Testing (BAT) in Hazelnut Allergy (Hazelnut BAT Study)

Condition:   Food Allergy
Interventions:   Diagnostic Test: Food challenge;   Diagnostic Test: skin testing;   Diagnostic Test: blood sampling
Sponsors:   University of Zurich;   ADR-AC Laboratory, Berne
Recruiting - verified March 2017

Registry of Food Allergy Oral Immunotherapy Treatment

Condition:   Food Allergy
Sponsor:   Food Allergy Support Team
Not yet recruiting - verified February 2017

E-B-FAHF-2, Multi OIT and Xolair (Omalizumab) for Food Allergy

Condition:   Food Allergy
Interventions:   Drug: Chinese Herbal Medication;   Drug: Placebo;   Drug: Omalizumab;   Drug: Multi OIT
Sponsor:   Xiu-Min Li
Recruiting - verified September 2016

Association Between Asthma and Food Allergy

Conditions:   Food Allergy Suspected;   Food Allergy Proved
Intervention:   Other: Pulmonary function test
Sponsor:   University Hospital, Montpellier
Recruiting - verified August 2016

Oral Immunotherapy in Food Allergy in Finland

Conditions:   Food Hypersensitivity;   Immune System Diseases;   Anaphylaxis
Intervention:   Dietary Supplement: Milk
Sponsor:   Helsinki University Central Hospital
Enrolling by invitation - verified February 2017

Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients

Condition:   Food Allergy
Intervention:   Drug: Xolair
Sponsors:   Stanford University;   National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified March 2017

Multi Immunotherapy to Test Tolerance and Xolair

Condition:   Food Allergy
Interventions:   Drug: Omalizumab;   Drug: Food Flour Buildup
Sponsors:   Kari Christine Nadeau;   Icahn School of Medicine at Mount Sinai;   Children's Hospital of Philadelphia;   Ann & Robert H Lurie Children's Hospital of Chicago;   Children's Hospital Medical Center, Cincinnati;   Children's Hospital Los Angeles;   University of Washington
Completed - verified March 2017

iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions

Condition:   Food Allergy
Interventions:   Drug: Omeprazole;   Drug: Placebo
Sponsors:   University of Zurich;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   University of Nebraska Lincoln;   Region Hoverstaden;   University of Manchester;   Hospital San Carlos, Madrid
Completed - verified May 2017

Natural History and Genetics of Food Allergy and Related Conditions

Conditions:   Food Allergy;   Loeys-Dietz Syndrome
Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 3, 2017

Pertussis Immunisation and Food Allergy

Condition:   Food Allergy
Sponsors:   Telethon Kids Institute;   Princess Margaret Hospital for Children;   Royal Children's Hospital;   Women's and Children's Hospital, Australia;   Sydney Children's Network;   National Health and Medical Research Council, Australia
Recruiting - verified October 2016

Self-injection and Self-management

Condition:   Food Allergy
Intervention:   Behavioral: Simulation of epinephrine self-injection
Sponsors:   Icahn School of Medicine at Mount Sinai;   Fordham University
Completed - verified June 2016

Partially Hydrolyzed Whey Formula in Cow's Milk Allergic Patients

Condition:   Food Allergy
Intervention:   Other: Partially Hydrolyzed Whey formula
Sponsors:   Icahn School of Medicine at Mount Sinai;   Nestlé
Completed - verified December 2016

Molecular Analysis of IgE Antibodies in Walnut Allergic Patients

Condition:   Food Allergy
Intervention:   Other: walnut allergy provocation
Sponsors:   University of Zurich;   Paul Ehrlich Institute Langen;   Hospital Clinic of Barcelona;   St. Marien Hospital Bonn;   Thermo Fisher Scientific
Completed - verified May 2017

Intranasal Diagnostics in Food Allergy: a Feasibility Study

Condition:   Food Allergy
Interventions:   Other: Intranasal challenge with active substance (food protein);   Other: Intranasal challenge with placebo
Sponsors:   Imperial College London;   National Institute for Health Research, United Kingdom
Enrolling by invitation - verified March 2017

Can Vitamin D Supplementation in Infants Prevent Food Allergy in the First Year of Life? The VITALITY Trial

Condition:   Food Allergy
Interventions:   Drug: Vitamin D;   Drug: placebo
Sponsor:   Murdoch Childrens Research Institute
Recruiting - verified August 2016

Impact of the Therapeutic Education on the Quality of Life of the Child Suffering of Food Allergy IgE-mediated

Condition:   IgE Mediated Food Allergy
Intervention:   Behavioral: Therapeutic education group
Sponsors:   Assistance Publique - Hôpitaux de Paris;   French Society of Allergology;   Stallergenes laboratories;   Picot-Lactalis laboratory;   ALK Industries
Active, not recruiting - verified July 2016

Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies

Conditions:   Peanut Allergies;   Tree Nut Allergies;   Other Food Allergies
Sponsors:   University of Colorado, Denver;   National Institutes of Health (NIH)
Recruiting - verified February 2017

Health Related Quality of Life in Children With Food Allergy: Comparison to Controls and Other Chronic Diseases

Condition:   Children With Food Allergy
Intervention:   Other: filling questionnary to quality of life
Sponsor:   Centre Hospitalier Universitaire de Nice
Completed - verified March 2016

Baked Egg or Egg Oral Immunotherapy for Children With Egg Allergy

Condition:   Food Allergy
Interventions:   Drug: Egg Oral Immunotherapy;   Drug: Baked Egg
Sponsors:   Hugh A Sampson, MD;   National Institute of Allergy and Infectious Diseases (NIAID);   Consortium of Food Allergy Research
Active, not recruiting - verified February 2017

Molecular Basis of Food Allergy

Conditions:   Food Allergy;   Eosinophilic Esophagitis
Sponsors:   Children's Hospital of Philadelphia;   University of Pennsylvania;   National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified December 2016

The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults

Condition:   Food Allergy
Intervention:   Dietary Supplement: Dietary supplement
Sponsor:   Helsinki University Central Hospital
Active, not recruiting - verified January 2017

Quality of Life in Food Allergic Families

Condition:   Food Allergy
Interventions:   Behavioral: Counseling;   Behavioral: Placebo phone call
Sponsor:   University of Michigan
Completed - verified June 2016

Sublingual Immunotherapy for Food Allergy

Condition:   Food Allergies
Intervention:   Other: Food Drops: Food Allergens (peptides)
Sponsor:   University of Missouri-Columbia
Terminated - verified June 2016

An Observational Study of Childhood Food Allergy

Conditions:   Food Hypersensitivity;   Peanut Hypersensitivity;   Egg Hypersensitivity;   Milk Hypersensitivity
Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Consortium of Food Allergy Research
Completed - verified September 2016

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