Opioid Dependence



Probuphine Innovations for Clinical Effectiveness (PRINCE)


Condition:   Opioid Dependence
Intervention:   Device: ActiGraph Link
Sponsors:   Healthcare Innovation Technology Lab;   Braeburn Pharmaceuticals
Not yet recruiting - verified August 2016


A Naturalistic Study of Adolescents and Young Adults in Treatment for Opioid Dependence


Condition:   Opioid Dependence
Intervention:   Other: Naturalistic Prospective Cohort
Sponsor:   Yale University
Recruiting - verified August 2016


Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence


Conditions:   Opiate Dependence;   Sexually Transmitted Diseases;   HIV
Interventions:   Behavioral: Acceptance and Commitment Therapy;   Behavioral: Information Motivation Behavioral Model
Sponsor:   Rhode Island Hospital
Recruiting - verified April 2017


Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency Departments


Condition:   Opioid Dependence
Interventions:   Behavioral: Strengths-based Case Management (SBCM);   Behavioral: Screening, Assessment, and Referral (SAR)
Sponsors:   New York University School of Medicine;   Wright State University
Recruiting - verified October 2016


The Safety of Using Buprenorphine With Naloxone in a Buccal Film to Initiate Treatment of Opioid Dependent Subjects


Condition:   Opioid Dependence
Interventions:   Drug: BEMA Buprenorphine NX;   Drug: Buprenorphine
Sponsor:   BioDelivery Sciences International
Withdrawn - verified May 2017


Oxytocin Treatment of Opioid Dependence


Conditions:   Opioid Dependence;   Opioid Withdrawal
Interventions:   Drug: Intranasal Oxytocin Spray;   Drug: Placebo
Sponsor:   University of North Carolina, Chapel Hill
Enrolling by invitation - verified May 2017


Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependence


Condition:   Opioid Dependence
Interventions:   Drug: CI-581aa;   Drug: Naltrexone titration and XR-NTX initiation
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Active, not recruiting - verified October 2016


Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone


Condition:   Opioid Dependence
Intervention:   Drug: Buprenorphine/naloxone
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2017


Study of Treatment for Opioid Dependence and Anxiety Disorders


Conditions:   Anxiety Disorders;   Opiate Addiction
Interventions:   Behavioral: I-CBT;   Behavioral: IDC
Sponsor:   Mclean Hospital
Recruiting - verified February 2017


Buprenorphine Treatment for Opioid Dependence


Condition:   Opioid Dependence
Intervention:   Drug: Buprenorphine
Sponsors:   Yale University;   United States Department of Defense
Recruiting - verified July 2016


Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Population


Condition:   Opioid Dependence
Interventions:   Drug: Suboxone Sublingual Film;   Drug: Zubsolv sublingual tablets
Sponsor:   Indivior Inc.
Completed - verified January 2017


Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia


Conditions:   Opiate Dependence;   Stimulant Dependence
Intervention:   Drug: Atomoxetine
Sponsor:   Yale University
Completed - verified April 2017


Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence


Conditions:   Opioid-Related Disorders;   Opiate Dependence
Interventions:   Drug: Buprenorphine/naloxone sublingual tablets;   Drug: Buprenorphine
Sponsors:   Orexo AB;   Worldwide Clinical Trials
Completed - verified April 2017


Evaluation of BEMA® Buprenorphine NX for Buprenorphine Induction of Opioid Dependent Subjects


Condition:   Opioid Dependence
Intervention:   Drug: Buprenorphine and naloxone
Sponsor:   BioDelivery Sciences International
Withdrawn - verified May 2017


An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjects


Condition:   Opioid Dependence
Intervention:   Drug: BEMA Buprenorphine NX films
Sponsor:   BioDelivery Sciences International
Completed - verified February 2017


Starting Treatment With Agonist Replacement Therapies Follow-up Study


Condition:   Opioid Dependence
Intervention:  
Sponsors:   University of California, Los Angeles;   National Institute on Drug Abuse (NIDA)
Completed - verified August 2016


The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Drug: Vivitrol;   Behavioral: Employment-based opiate abstinence reinforcement;   Other: Usual Care Control
Sponsors:   Johns Hopkins University;   National Institute on Drug Abuse (NIDA)
Active, not recruiting - verified April 2017


Improved Strategies for Outpatient Opioid Detoxification


Condition:   Opioid Dependence
Interventions:   Drug: oral naltrexone;   Drug: Buprenorphine;   Drug: Vivitrol
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting - verified November 2016


Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment


Conditions:   Chronic Pain;   Opiate Dependence
Interventions:   Behavioral: Cognitive-Behavioral Therapy for Pain and Opioid Dependence;   Behavioral: Methadone Drug Counseling
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified June 2016


Chronic Pain and Opioid Dependence Assessment and Treatment


Conditions:   Chronic Pain;   Opioid Dependency
Intervention:   Behavioral: Integrated Cognitive Behavioral Therapy
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified June 2016


ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Drug: VIVITROL® 380 mg;   Drug: Placebo
Sponsor:   Alkermes, Inc.
Completed - verified December 2016


Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Behavioral: Behavioral: Buprenorphine/naloxone maintenance (Mtn);   Behavioral: Behavioral: Buprenorphine/naloxone detoxification (Dtx)
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified January 2017


Methadone Maintenance & HIV Risk in Ukraine


Condition:   Opioid Dependence
Intervention:   Drug: Methadone
Sponsors:   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
Completed - verified September 2016


Pharmacogenetics of Disulfiram for Cocaine


Conditions:   Cocaine Dependence;   Opioid Dependence
Interventions:   Drug: Disulfiram;   Drug: Methadone;   Behavioral: CBT;   Other: Lactose
Sponsors:   Baylor College of Medicine;   National Institute on Drug Abuse (NIDA);   Yale University
Completed - verified February 2017


Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14


Conditions:   Opioid Dependence;   Substance-Related Disorders
Intervention:   Drug: Buprenorphine/naloxone
Sponsors:   National Institute on Drug Abuse (NIDA);   New York MDRU
Completed - verified August 2016

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