Drug Addiction



Probuphine Innovations for Clinical Effectiveness (PRINCE)


Condition:   Opioid Dependence
Intervention:   Device: ActiGraph Link
Sponsors:   Healthcare Innovation Technology Lab;   Braeburn Pharmaceuticals
Not yet recruiting - verified August 2016


Long-acting Naltrexone for Pre-release Prisoners


Condition:   Opiate Addiction
Interventions:   Drug: XR-NTX;   Other: place of residence;   Other: opioid treatment program
Sponsors:   Friends Research Institute, Inc.;   National Institute on Drug Abuse (NIDA)
Recruiting - verified January 2017


A Naturalistic Study of Adolescents and Young Adults in Treatment for Opioid Dependence


Condition:   Opioid Dependence
Intervention:   Other: Naturalistic Prospective Cohort
Sponsor:   Yale University
Recruiting - verified August 2016


Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence


Conditions:   Opiate Dependence;   Sexually Transmitted Diseases;   HIV
Interventions:   Behavioral: Acceptance and Commitment Therapy;   Behavioral: Information Motivation Behavioral Model
Sponsor:   Rhode Island Hospital
Recruiting - verified April 2017


Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans


Condition:   Opiate Addiction
Interventions:   Drug: CBD 400 mg;   Drug: CBD 800 mg;   Drug: Control (placebo)
Sponsors:   Hurd,Yasmin, Ph.D.;   GW Research Ltd
Recruiting - verified April 2017


Oxytocin Treatment of Opioid Dependence


Conditions:   Opioid Dependence;   Opioid Withdrawal
Interventions:   Drug: Intranasal Oxytocin Spray;   Drug: Placebo
Sponsor:   University of North Carolina, Chapel Hill
Enrolling by invitation - verified May 2017


Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependence


Condition:   Opioid Dependence
Interventions:   Drug: CI-581aa;   Drug: Naltrexone titration and XR-NTX initiation
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Active, not recruiting - verified October 2016


Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexone


Condition:   Opioid Dependence
Intervention:   Drug: Buprenorphine/naloxone
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2017


Study of Treatment for Opioid Dependence and Anxiety Disorders


Conditions:   Anxiety Disorders;   Opiate Addiction
Interventions:   Behavioral: I-CBT;   Behavioral: IDC
Sponsor:   Mclean Hospital
Recruiting - verified February 2017


Buprenorphine Treatment for Opioid Dependence


Condition:   Opioid Dependence
Intervention:   Drug: Buprenorphine
Sponsors:   Yale University;   United States Department of Defense
Recruiting - verified July 2016


On-site Evaluation of Substances Consumption on Opiate Maintenance


Condition:   Opiate Addiction
Interventions:   Procedure: urine drug testing;   Other: no test
Sponsor:   University Hospital, Toulouse
Recruiting - verified February 2017


Atomoxetine for ATS and Opioid Dependence During Buprenorphine Maintenance Treatment in Malaysia


Conditions:   Opiate Dependence;   Stimulant Dependence
Intervention:   Drug: Atomoxetine
Sponsor:   Yale University
Completed - verified April 2017


Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence


Conditions:   Opioid-Related Disorders;   Opiate Dependence
Interventions:   Drug: Buprenorphine/naloxone sublingual tablets;   Drug: Buprenorphine
Sponsors:   Orexo AB;   Worldwide Clinical Trials
Completed - verified April 2017


Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans


Condition:   Opiate Addiction
Interventions:   Drug: Cannabidiol 400;   Drug: Cannabidiol 800;   Drug: Control
Sponsor:   Hurd,Yasmin, Ph.D.
Completed - verified October 2016


The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Drug: Vivitrol;   Behavioral: Employment-based opiate abstinence reinforcement;   Other: Usual Care Control
Sponsors:   Johns Hopkins University;   National Institute on Drug Abuse (NIDA)
Active, not recruiting - verified April 2017


Cognitive-Behavioral Therapy for Pain and Opioid Dependence in Methadone Maintenance Treatment


Conditions:   Chronic Pain;   Opiate Dependence
Interventions:   Behavioral: Cognitive-Behavioral Therapy for Pain and Opioid Dependence;   Behavioral: Methadone Drug Counseling
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified June 2016


ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids


Condition:   Opiate Dependence
Interventions:   Drug: Medisorb naltrexone 75 mg;   Drug: Medisorb naltrexone 150 mg;   Drug: Medisorb naltrexone 300 mg;   Drug: Hydromorphone (10 mg/mL);   Drug: Naloxone Challenge and Oral Naltrexone Tolerability Testing
Sponsor:   Alkermes, Inc.
Completed - verified November 2016


Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department


Condition:   Opiate Addiction
Interventions:   Behavioral: Brief Negotiation Interview (BNI);   Drug: Buprenorphine Initiation
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified August 2016


Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site


Condition:   Opiate Addiction
Interventions:   Drug: Depot naltrexone;   Other: Treatment as Usual (TAU)
Sponsors:   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
Completed - verified September 2016


ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Drug: VIVITROL® 380 mg;   Drug: Placebo
Sponsor:   Alkermes, Inc.
Completed - verified December 2016


Prospective Cohort of Opiate Dependent Patients on Buprenorphine/Naloxone for Maintenance


Condition:   Opiate Dependence
Intervention:   Other: Mobile Access
Sponsor:   Yale University
Completed - verified August 2016


Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence


Condition:   Opiate Dependence
Interventions:   Behavioral: Behavioral: Buprenorphine/naloxone maintenance (Mtn);   Behavioral: Behavioral: Buprenorphine/naloxone detoxification (Dtx)
Sponsors:   Yale University;   National Institute on Drug Abuse (NIDA)
Completed - verified January 2017


Buprenorphine Maintenance for Opiate Dependence - 6


Conditions:   Opioid-Related Disorders;   Substance-Related Disorders
Intervention:   Drug: Buprenorphine
Sponsors:   National Institute on Drug Abuse (NIDA);   University of Pennsylvania
Completed - verified December 1993


Trial of Buprenorphine/Naloxone for Opiate Dependence - 2


Conditions:   Opioid-Related Disorders;   Substance-Related Disorders
Intervention:   Drug: Buprenorphine/naloxone
Sponsors:   National Institute on Drug Abuse (NIDA);   University of Pennsylvania
Completed - verified December 2002


Buprenorphine/Naloxone for Treatment of Opiate Dependence - 9


Condition:   Opioid-Related Disorders
Intervention:   Drug: Buprenorphine/naloxone
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified August 2008

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