Cocaine Dependence



Deep Brain Stimulation of the Sub-Thalamic Nucleus to Treat Severe and Treatment-resistant Cocaine Addiction.


Condition:   Cocaine Addiction
Intervention:   Device: Deep brain stimulation of the subthalamic nuclei (STN-DBS)
Sponsor:   Assistance Publique - Hôpitaux de Paris
Recruiting - verified August 2016


Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Dietary Supplement: N-acetylcysteine;   Other: Placebo
Sponsor:   Yale University
Recruiting - verified December 2016


Complementary Combination Therapy for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Doxazosin;   Drug: Modafinil;   Drug: cocaine;   Drug: Placebo
Sponsor:   Baylor College of Medicine
Recruiting - verified October 2016


Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET


Condition:   Cocaine Dependence
Interventions:   Drug: Methylphenidate;   Drug: Alpha Methyl Para Tyrosine (AMPT);   Other: [11C]PHNO;   Other: [11C]raclopride
Sponsor:   Yale University
Recruiting - verified December 2016


A Study of Baclofen ER


Condition:   Cocaine Dependence
Interventions:   Drug: Baclofen ER;   Drug: Placebo
Sponsor:   University of Pennsylvania
Withdrawn - verified September 2016


A Sequenced Behavioral and Medication Intervention for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Behavioral: Computer-assisted behavior therapy;   Drug: Mixed amphetamine salts;   Drug: Computer-assisted CBT plus placebo
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2017


Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Adderall-ER;   Drug: Topiramate;   Other: Placebo
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Active, not recruiting - verified March 2017


A Multi-Center Trial of Nepicastat for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Nepicastat;   Drug: Placebo
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified April 2017


A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Varenicline;   Drug: Placebo
Sponsor:   University of Pennsylvania
Recruiting - verified September 2016


Oxytocin in Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Oxytocin;   Drug: Saline
Sponsor:   Medical University of South Carolina
Recruiting - verified September 2016


The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Ketamine;   Drug: Midazolam
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Recruiting - verified October 2016


Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence


Condition:   Cocaine Dependence
Intervention:   Drug: Lisdexamfetamine
Sponsors:   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA)
Completed - verified October 2016


Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: levodopa carbidopa and entacapone (LCE);   Drug: Placebo
Sponsor:   New York State Psychiatric Institute
Completed - verified October 2016


Citalopram for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Citalopram;   Drug: Citalopram;   Drug: Placebo
Sponsors:   Joy Schmitz;   National Institute on Drug Abuse (NIDA)
Completed - verified May 2017


Cognitive Remediation for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: levodopa/carbidopa;   Drug: Ropinirole;   Drug: Placebo
Sponsor:   The University of Texas Health Science Center, Houston
Completed - verified May 2017


Psychopharmacology for Cocaine Dependence - Buspirone


Condition:   Cocaine Dependence
Interventions:   Drug: Buspirone;   Drug: Placebo for Buspirone;   Drug: Methylphenidate;   Drug: Placebo for Methylphenidate
Sponsor:   The University of Texas Health Science Center, Houston
Completed - verified May 2017


Effectiveness of Enhanced Treatments for Drug Dependence


Condition:   Cocaine Dependence
Intervention:   Behavioral: Telephone Monitoring and Counseling - Enhanced
Sponsor:   University of Pennsylvania
Completed - verified March 2017


Pharmacogenetics of Doxazosin for Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Doxazosin;   Drug: Placebo
Sponsors:   Baylor College of Medicine;   National Institute on Drug Abuse (NIDA)
Completed - verified February 2017


Reward Processing in Cocaine Addiction


Conditions:   Drug Abuse;   Cocaine Dependence
Intervention:  
Sponsors:   National Institute on Drug Abuse (NIDA);   National Institute of Mental Health (NIMH)
Completed - verified April 8, 2013


Multisite Controlled Trial of Cocaine Vaccine


Condition:   Cocaine Dependence
Interventions:   Drug: TA-CD Vaccination;   Other: Placebo Injection
Sponsors:   Baylor College of Medicine;   National Institute on Drug Abuse (NIDA);   US Department of Veterans Affairs Cooperative Studies Program;   VA Maryland Health Care System;   Columbia University;   VA New York Harbor Healthcare System;   University of Pennsylvania;   Johns Hopkins University;   University of Cincinnati;   Celtic Pharma Development Services
Completed - verified February 2017


Brain Glutamate Receptors and Cocaine Dependence


Conditions:   Drug Abuse;   Cocaine Dependence
Intervention:  
Sponsor:   National Institute on Drug Abuse (NIDA)
Terminated - verified March 19, 2013


Caffeine and Cocaine


Condition:   Cocaine Dependence
Interventions:   Drug: Caffeine 150 MG;   Drug: Placebo;   Drug: Amphetamine;   Drug: Caffeine 300 MG
Sponsors:   Virginia Commonwealth University;   National Institute on Drug Abuse (NIDA);   The University of Texas Health Science Center, Houston
Completed - verified February 2017


Metabolic Effects of Cocaine


Condition:   Cocaine Dependence
Interventions:   Drug: cocaine;   Drug: hydrocortisone
Sponsors:   National Institute on Drug Abuse (NIDA);   National Alliance for Research on Schizophrenia and Depression
Completed - verified October 2002


Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence


Condition:   Cocaine Dependence
Interventions:   Drug: Risperidone;   Drug: Placebo
Sponsors:   Massachusetts General Hospital;   Janssen, LP
Completed - verified March 2017


Serotonin, Impulsivity, and Cocaine Dependence Treatment


Condition:   Cocaine Dependence
Intervention:   Drug: citalopram
Sponsor:   National Institute on Drug Abuse (NIDA)
Completed - verified February 2006

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